Le pronostic des tumeurs malignes primitives de la conjonctive

Chebbi, A.; Bouguila, H.; Boukari, M.; Lajmi, Houda; Bouzain, M.; Abess, I.; Malek, Ines; Mrad, Karima; Zeghal, I.; Nacef, L.

doi:10.1016/j.jfo.2014.10.017

Cited by 3 publications

(7 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The average consultation time for received patients was 10 months 13 days. Our results are close to those of Berete [16] and Chebbi [13] who found respec-tively average consultation durations of 14.28 months and 8.8 months. The exophthalmos observed as the main reason for consultation in the various studies would be the consequence of the late consultations observed in the majority of patients.…”

Section: • Consultation Deadlinesupporting

confidence: 90%

“…The average age of our patients was 44.3 years with extremes of 12 and 87 years. This malignant tumor of the conjunctiva would generally appear in elderly subjects as reported by Seck [7] and Chebbi [13] who had noted respective average ages of 50 years and 62 years. The resurgence in young adults in our study would be linked to the HIV pandemic; which is also the antecedent mainly observed in our patients (64.71%).…”

Section: • Agesupporting

confidence: 53%

See 1 more Smart Citation

Epidemio-Clinical-Histopathological Aspects and Therapeutics of Squamous Cell Carcinoma of the Conjunctival at the University Hospital Center of Bouake

Bile,

Djiguimde,

Diomandé

et al. 2024

OJOph

View full text Add to dashboard Cite

Introduction: Squamous cell carcinoma of the conjunctiva is one of the most common malignancies in the elderly. Purpose: To describe the specific aspects of squamous cell carcinoma of the conjunctiva and to determine the therapeutic modalities. Materials and Methods: Descriptive cross-sectional retrospective study carried out at the University Hospital Center of Bouake over a period of 9 years (From January 2015 to December 2023). We identified all malignant oculo-adnexal and orbital tumors whose histopathological diagnosis was confirmed; monitoring the sorting of squamous cell carcinomas of the conjunctiva among these cancers and studying the different parameters linked to them. Results: The average age of patients is 44.3 years. Male predominance with a sex ratio of 1.12. HIV was the majority ATCD with 64.7%. The main reason for consultation was exophthalmos (36.11%). The average consultation time was 10 months 13 days. Invasive differentiated conjunctival squamous cell carcinoma was predominant at 55.56%. Enucleation was the most performed surgical method. Conclusion: Squamous cell carcinoma of the conjunctiva is a malignant ocular tumor of the elderly whose frequency increases in young adults infected with HIV-AIDS. Invasive differentiated forms are increasingly encountered, limiting treatment to mutilating surgery.

show abstract

Section: • Consultation Deadlinesupporting

confidence: 90%

Section: • Agesupporting

confidence: 53%

Epidemio-Clinical-Histopathological Aspects and Therapeutics of Squamous Cell Carcinoma of the Conjunctival at the University Hospital Center of Bouake

Bile,

Djiguimde,

Diomandé

et al. 2024

OJOph

View full text Add to dashboard Cite

show abstract

“…We compared the two groups for balance in terms of predefined factors that could have a bearing on aetiology or recurrence: age, sex, smoking history, outdoor occupation, HIV status, CD4 count, vitamin A concentration, tumour size, prior excision, and histological grade 3, 5, 8, 9. The primary analysis of the primary outcome and the safety analysis were done by intention to treat.…”

Section: Methodsmentioning

confidence: 99%

“…The highest recorded recurrence is 67% 4 . Recurrence is a particular problem in sub-Saharan Africa, where it typically occurs in 30–40% of patients 4, 5, 6, 7. In temperate climates, recurrence typically occurs in 5–25% of patients (appendix).…”

Section: Introductionmentioning

confidence: 99%

“…In temperate climates, recurrence typically occurs in 5–25% of patients (appendix). Surgical outcomes seem to be affected by delays in diagnosis, tumour size, histological grade, ocular location, scleral invasion, excision margin involvement, prior excision, and coexisting xeroderma pigmentosum 5, 8, 9. Several adjunctive treatment regimens are used during or after surgery to reduce recurrence: cryotherapy, topical chemotherapy (mitomycin and fluorouracil), interferon alfa-2b, retinoic acid, and radiotherapy (appendix p 1, 3, 7, 11, 13, 14).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Topical fluorouracil after surgery for ocular surface squamous neoplasia in Kenya: a randomised, double-blind, placebo-controlled trial

Gichuhi

Macharia²,

Kabiru³

et al. 2016

The Lancet Global Health

View full text Add to dashboard Cite

SummaryBackgroundOcular surface squamous neoplasia (OSSN) is an aggressive eye tumour particularly affecting people with HIV in Africa. Primary treatment is surgical excision; however, tumour recurrence is common. We assessed the effect of fluorouracil 1% eye drops after surgery on recurrence.MethodsWe did this multicentre, randomised, placebo-controlled trial in four centres in Kenya. We enrolled patients with histologically proven OSSN aged at least 18 years. After standard surgical excision, participants were randomly allocated to receive either topical fluorouracil 1% or placebo four times a day for 4 weeks. Randomisation was stratified by surgeon, and participants and trial personnel were masked to assignment. Patients were followed up at 1 month, 3 months, 6 months, and 12 months. The primary outcome was clinical recurrence (supported by histological assessment where available) by 1 year, and analysed by intention to treat. The sample size was recalculated because events were more common than anticipated, and trial enrolment was stopped early. The trial was registered with Pan-African Clinical Trials Registry (PACTR201207000396219).FindingsBetween August, 2012, and July, 2014, we assigned 49 participants to fluorouracil and 49 to placebo. Four participants were lost to follow-up. Recurrences occurred in five (11%) of 47 patients in the fluorouracil group and 17 (36%) of 47 in the placebo group (odds ratio 0·21, 95% CI 0·07–0·63; p=0·01). Adjusting for passive smoking and antiretroviral therapy had little effect (odds ratio 0·23; 95% CI 0·07–0·75; p=0·02). Adverse effects occurred more commonly in the fluorouracil group, although they were transient and mild. Ocular discomfort occurred in 43 of 49 patients in the fluorouracil group versus 36 of 49 in the placebo group, epiphora occurred in 24 versus five, and eyelid skin inflammation occurred in seven versus none.InterpretationTopical fluorouracil after surgery substantially reduced recurrence of OSSN, was well-tolerated, and its use recommended.FundingBritish Council for Prevention of Blindness and the Wellcome Trust.

show abstract