Le paludisme grave : une cause de mort subite. À propos de 18 cas de découverte post-mortem

Djodjo, M.; Botti, K.; Ebouat, K.M.E.V.; Konate, Z.; Koffi, K; Etté, H. Yapo

doi:10.1016/j.medleg.2015.06.004

Cited by 1 publication

(3 citation statements)

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“…In our case, the external examination found mucocutaneous jaundice as was the case in an autopsy series of 18 sudden deaths due to severe malaria-discovered postmortem (Djodjo et al 2015). Its incidence is reported to range from 11.5 to 62% (Djodjo et al 2015).…”

Section: Discussionsupporting

confidence: 64%

“…The diagnosis is based on the observation of sequestrated parasitized red blood cells in the brain vessels. They may obstruct the lumen of small capillaries or be margined against the endothelium of larger vessels (Djodjo et al 2015). These histological aspects reflect the properties of the parasitized red blood cells to adhere to the endothelial cells of capillaries and venules (Milner et al 2015).…”

Section: Discussionmentioning

confidence: 99%

“…These histological aspects reflect the properties of the parasitized red blood cells to adhere to the endothelial cells of capillaries and venules (Milner et al 2015). Red blood cells acquire these cytoadherence properties when parasitized by mature forms of Plasmodium falciparum (Djodjo et al 2015). The presence of malaria pigment is another important element of the histological diagnosis, as well as other histological findings (although inconsistent) such as ring hemorrhages around necrotic vessels and microthrombi (Milner et al 2015).…”

Section: Discussionmentioning

confidence: 99%

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Imported malaria in adults: about a case of cerebral malaria

Abderrahim

Gharsallaoui

Daly

et al. 2022

Egypt J Forensic Sci

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Background Malaria is the first parasitic infection endemic in the world caused by parasites species of Plasmodium. Cerebral malaria (CM) is a rapidly progressive and severe form of Plasmodium falciparum infection, characterized by a greater accumulation of red blood cells parasitized by Plasmodium falciparum in the brain. The diagnosis of malaria is usually made in living patients from a blood sample taken in the course of a fever on return from an endemic country, whereas CM, often associated with fatal outcomes even in treated subjects, is usually diagnosed at autopsy. Case presentation We present the case of a 36-year-old man who died a few days after returning from a business trip to the Ivory Coast. As a result of an unclear cause of death, a medicolegal autopsy was ordered. Autopsy findings revealed massive congestion and edema of the brain with no other macroscopic abnormalities at organ gross examination. Histology and laboratory tests were conducted revealing a Plasmodium falciparum infection, with numerous parasitized erythrocytes containing dots of hemozoin pigment (malaria pigment) in all examined brain sections and all other organs. Death was attributed to cerebral malaria with multiple organ failure. Conclusions This report summarizes several features for the diagnosis of malaria and how postmortem investigations, as well as histology and laboratory diagnosis, may lead to a retrospective diagnosis of a fatal complicated form with cerebral involvement.

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Section: Discussionsupporting

confidence: 64%

Section: Discussionmentioning

confidence: 99%