Le nouvel âge de la primaquine contre le paludisme

Simon, Fabrice; Monbrison, Frédérique de; Béavogui, Abdoul Habib; Pradines, Bruno; Ragot, Céline; Moalic, Jean-Luc; Rapp, C.; Picot, Stéphane

doi:10.1016/j.medmal.2008.01.011

Cited by 8 publications

(2 citation statements)

References 49 publications

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“…The treatment for proven attacks is based on chloroquine (25 mg/kg for three days). The treatment against dormant stages in the liver consists of a radical cure with primaquine (0.5 mg/kg/d for 14 days) in patients without G6PD deficiency [ 17 , 18 ]. Failures of primaquine are unusual, mostly due to poor observance or inadequate dosage [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

The challenge of diagnosing Plasmodium ovale malaria in travellers: report of six clustered cases in french soldiers returning from West Africa

Laval¹,

Oliver

Rapp

et al. 2010

Malar J

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BackgroundPlasmodium ovale is responsible for 5% of imported malaria in French travellers. The clinical and biological features of six clustered cases of P. ovale malaria in an army unit of 62 French soldiers returning from the Ivory Coast are reported.Case reportAll patients were symptomatic and developed symptoms on average 50 days after their return and 20 days after the end of chemoprophylaxis (doxycycline). Clinical features included fever (6/6), mostly tertian (4/6), aches (6/6), nausea (3/6), abdominal pain (2/6), diarrhoea (2/6), or cough (2/6). Thrombocytopaenia was lower than 100,000/mm3 in half the cases only, and the haemoglobin count was normal for all patients. The diagnosis was made after at least three thick and thin blood smear searches. Parasitaemia was always lower than 0.5%. All rapid diagnostic tests were negative for HRP2 and pLDH antigens.DiscussionPlasmodium ovale malaria is currently a problem to diagnose in travellers, notably in French soldiers returning from the Ivory Coast. Early attempts at diagnosis are difficult due to the lack of specific clinical features, the rarity of biological changes and the poor sensitivity of diagnostic tools to detect low parasitaemia. Thus, the diagnosis is commonly delayed or missed. Physicians should be aware of this diagnostic challenge to avoid relapses and provide prompt and adequate treatment with chloroquine and radical cure with primaquine.

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Section: Discussionmentioning

confidence: 99%

The challenge of diagnosing Plasmodium ovale malaria in travellers: report of six clustered cases in french soldiers returning from West Africa

Laval¹,

Oliver

Rapp

et al. 2010

Malar J

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“…We encapsulated the weakly basic quinine drug chloroquine using the AS gradient into PFSUVs achieving an EE of 95.4%. Further development of this delivery system encapsulated with chloroquine and other quinine‐based drugs such as primaquine could be highly beneficial for liver‐stage malaria treatment . Another liver‐related infectious disease related to liver impairment is viral hepatitis (hepatitis B and hepatitis C) resulting in liver cirrhosis and hepatocellular carcinoma .…”

Section: Resultsmentioning

confidence: 99%

Phospholipid‐Free Small Unilamellar Vesicles for Drug Targeting to Cells in the Liver

Zhang

Böttger

Zhu

et al. 2019

Small

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It is reported that cholesterol (Chol) and TWEEN 80 at a molar ratio of 5:1 can form small unilamellar vesicles (SUVs) using a staggered herringbone micromixer. These phospholipid‐free SUVs (PFSUVs) can be actively loaded with a model drug for targeting hepatocytes via the endogenous apolipoprotein mechanism. PFSUVs particles with compositions of Chol:TWEEN 80 ranging between 1.5:1 and 5:1 (mol/mol) can be produced with a mean diameter of ≈80 nm, but only the high‐Chol formulations (3:1 and 5:1) can retain a transmembrane gradient of ammonium sulfate for active loading of doxorubicin (DOX). Under cryo‐transmission electron microscopy, PFSUVs‐DOX displays a unilamellar bilayer structure with DOX molecules forming spindle‐shape aggregates inside the aqueous core. Relative to PEGylated liposomal doxorubicin (PLD) that exhibits little interaction with cells in various conditions, the cellular uptake of PFSUVs‐DOX is dependent on the presence of serum and enhanced with an increased concentration of apolipoproteins. After intravenous injection, the vast majority of PFSUVs‐DOX accumulates in the liver and DOX is detected in all liver cells (predominantly the hepatocytes), while PLD is captured only by the sinusoidal cells (i.e., macrophages). This report discloses an innovative lipid bilayer vesicle for highly efficient and selective hepatocyte targeting.

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Malaria attacks due to P. vivax or P. ovale in two French military teaching hospitals (2000 to 2009)

Demaison

Rapp

Laval³

et al. 2013

Médecine et Maladies Infectieuses

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Le nouvel âge de la primaquine contre le paludisme

Cited by 8 publications

References 49 publications

The challenge of diagnosing Plasmodium ovale malaria in travellers: report of six clustered cases in french soldiers returning from West Africa

The challenge of diagnosing Plasmodium ovale malaria in travellers: report of six clustered cases in french soldiers returning from West Africa

Phospholipid‐Free Small Unilamellar Vesicles for Drug Targeting to Cells in the Liver

Malaria attacks due to P. vivax or P. ovale in two French military teaching hospitals (2000 to 2009)

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