Le microbiote pulmonaire

Ploton, Marie-Caroline; Abakka, S.; Amouyal, E.; Besnard, Caroline; Dufour, L.; Harrif, S. El; Kipnis, C.; Prim, B.; Vignot, J.; Houdouin, Véronique

doi:10.1016/j.arcped.2017.04.007

Cited by 3 publications

(2 citation statements)

References 43 publications

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“…In China, a study from Southern Medical University (9) showed that, at the genus level in the lower respiratory tract of healthy people, Streptococcus was the most numerous, followed by Prevotella and Neisseria. Considering the differences in the living environment, eating habits, genetics, and other aspects of the study subjects, these factors can be expected to have a certain impact on airway microecology (10), so the results may be different. For example, smoking will lead to a significant increase in the abundance of Streptococcus, and a decrease in common symbiotic bacteria (11).…”

Section: Discussionmentioning

confidence: 99%

“…Frontiers in Medicine 10 frontiersin.org Zhu et al 10.3389/fmed.2022.946238 (16). Similarly to our study, Wang et al (17) also highlighted changes in non-pathogenic Proteobacteria in addition to the pathogenic microbiota during exacerbations, and it was found that Staphylococcus (potentially pathogenic bacteria) in the sputum of COPD patients and the absence of Veillonella, a potential commensal bacteria, were strongly associated with an increased risk of death after 1 year (18).…”

Section: Discussionmentioning

confidence: 99%

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A 16S rDNA sequencing-based analysis of airway microecology in patients with an acute exacerbation of chronic obstructive pulmonary disease: A cross-sectional study in Inner Mongolia, China

Zhu

Guo

et al. 2022

Front. Med.

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AimTo study the microecological characteristics of the airway and similarities and differences between healthy people and patients with the acute exacerbation of chronic obstructive pulmonary disease (AECOPD) in Inner Mongolia, and analyze the correlation between the characteristics of the airway microecological structure and clinical indicators of AECOPD patients.MethodsSputum samples from 36 healthy volunteers and 34 patients with AECOPD were detected by 16S rDNA high-throughput sequencing, and the airway microecological characteristics of healthy people and AECOPD patients were revealed by an alpha diversity analysis, beta diversity analysis, and LefSe difference analysis.ResultsThere were differences in the airway microecological structure between healthy people and AECOPD patients in Inner Mongolia. The airway microbiota composition of AECOPD patients showed an increase in the abundance of common pathogens and a decrease in the abundance of commensal bacteria, and the airway microbial diversity in AECOPD patients was lower than that in healthy people. Long-term use of inhaled glucocorticoid + long-acting β2 agonist mixture (ICS + LABA), procalcitonin (PCT), blood monocyte count (MONO), hemoglobin (HGB), D-dimer (D-D), and body temperature were negatively correlated with the alpha diversity of the airway micro-ecosystem.ConclusionThe airway microecological composition of the AECOPD population in Inner Mongolia was different from that of the healthy population, and the airway microecological diversity was lower than that of the healthy population. The long-term use of ICS + LABA preparation by patients with AECOPD leads to lower alpha diversity. Alpha diversity was negatively correlated with inflammatory markers (PCT, MONO, D-dimer, body temperature) and HGB in AECOPD patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%