Le carbimazole peut-il être à l’origine d’une anémie férriprive ?

Khattabi, A. El; Sekkach, Y.; Seddik, H.; Zahid, Hafid

doi:10.1016/j.pharma.2011.09.003

Cited by 2 publications

(1 citation statement)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These evidences suggested that digoxin may disturb transferrin signaling and iron metabolism. A number of drugs, such as omeprazole [ 23 ] and carbimazole [ 24 ], have been reported to cause iron deficiency and anemia. Here we identified digoxin as another suspected drug.…”

Section: Discussionmentioning

confidence: 99%

Digoxin-induced anemia among patients with atrial fibrillation and heart failure: clinical data analysis and drug-gene interaction network

Lin

Feng

et al. 2017

Oncotarget

View full text Add to dashboard Cite

Digoxin is widely used to treat various heart conditions. In order to clarify the association between digoxin and anemia adverse reaction, we inspected case reports submitted to the FDA Adverse Event Reporting System (FAERS) between January 2004 and December 2015. These reports involved 75618 atrial fibrillation patients and 15699 heart failure patients. Compared to other therapies, digoxin treatment was significantly more likely to be concurrent with anemia adverse reaction among both atrial fibrillation patients (pooled OR = 1.38, 95% CI 1.14–1.68, P-value = 0.001) and heart failure patients (pooled OR =1.50, 95% CI 1.33–1.59–, P =4.27×10−5). We further explored previously published evidences and found 821 human genes directly or indirectly interacting with digoxin. Functional analysis indicated that these genes were significantly enriched in the biological processes of iron transport, which are closely related to iron deficiency anemia. Taken together, our retrospective analysis demonstrated the significant association between digoxin treatment and anemia adverse reaction, which should be seriously considered in clinical practice. Functional enrichment analysis on digoxin-related genes warranted subsequent research on the underlying toxicological mechanisms.

show abstract

Section: Discussionmentioning

confidence: 99%