LDL‐receptors expression in HIV‐infected patients: relations to antiretroviral therapy, hormonal status, and presence of lipodystrophy

Petit, Jean‐Michel; Duong, Michel; Duvillard, Laurence; Florentin, E; Portier, H.; Lizard, Gérard; Brun, J; Gambert, Philippe; Verges, B

doi:10.1046/j.1365-2362.2002.00989.x

Cited by 28 publications

(22 citation statements)

References 29 publications

(37 reference statements)

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“…Firstly, the activity of hepatic LDL receptors is under hormonal control. Low level of thyroid hormones may inhibit LDL receptor expression and thus reduce the quantity and activity of LDL receptor leading to an increase of plasma LDL cholesterol [5]. Secondly, low level of thyroid hormones may depress the reactivity of target tissues to catecholamine, growth hormone, cortisol, and glucagons.…”

Section: Discussionmentioning

confidence: 99%

The Impact of Dietary Iodine Intake on Lipid Metabolism in Mice

Zhao

Yan

Sun

et al. 2010

Biol Trace Elem Res

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The present study has been designed to investigate the impact of dietary iodine intake on lipid metabolism in mice, including iodine deficiency and iodine excess. Different amounts of iodine mixed in the drinking water were continuously administered to mice. The body weights and the levels of urinary iodine were measured 8 months after the treatment. Thyroid hormones in the serum were detected by chemiluminescence immunoassay. Serum total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol and low-density lipoprotein cholesterol (LDL-C) were determined enzymatically by automatic analyzer. Results showed that the urine iodine concentrations paralleled the amounts of iodine intakes. No statistical differences of body weights among different groups were found. The levels of thyroid hormones were dramatically decreased in iodine deficiency while no significant differences were found between iodine excess groups and normal iodine group. In iodine deficiency groups, the levels of TG, TC, and LDL were increased at varying degrees. In iodine excess groups, the levels of TG in the male mice and the levels of TC in the female mice were much lower than normal iodine group. In conclusion, dietary iodine intake may affect the metabolism of serum lipids. Hypothyroid function induced by iodine deficiency may be responsible for the changes of lipids. Higher iodine intake might benefit lipid metabolism.

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Section: Discussionmentioning

confidence: 99%

The Impact of Dietary Iodine Intake on Lipid Metabolism in Mice

Zhao

Yan

Sun

et al. 2010

Biol Trace Elem Res

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“…A lower LDL-R expression in HIV patients with lipodystrophy was reported by Petit JM et al [43]. This lower LDL receptor activity could be a result of the effect of PIs treatment.…”

Section: Discussionmentioning

confidence: 54%

“…The delayed VLDL, IDL and LDL uptake in subjects with lipodystrophy suggests a decrease in LDL receptor activity [19,43]. A lower LDL-R expression in HIV patients with lipodystrophy was reported by Petit JM et al [43].…”

Section: Discussionmentioning

confidence: 94%

Disturbance of Apolipoprotein B100 Containing Lipoprotein Metabolism in Severe Hyperlipidemic and Lipodystrophic HIV Patients on Combined Antiretroviral Therapy: Evidences of Insulin Resistance Effect

Ouguerram¹,

Zaïr²,

Billon³

et al. 2008

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The aim was to study the mechanisms involved in the dyslipidemia associated with lipodystrophy in HIV infected patients on antiretroviral therapy (ART). We investigated the in vivo kinetics of apolipoprotein B100 (apoB) containing lipoproteins using a 14 h primed constant infusion of [5,5,5, (2)H(3)] leucine and compartmental modelling in normolipidemic without lipodystrophy (7 patients, NLD) or dyslipidemic with lipodystrophy (7 patients, LD) treated with ART. Subjects in group LD showed higher plasma triglycerides (5.73+/-3.58 vs 1.29+/-0.54 g/L, p<0.005), total cholesterol (2.98+/-0.95 vs 1.74+/-0.26 g/L, p<0.05), apoB (1.49+/-1.11 vs 0.51+/-0.11 g/L, p<0.005) and apolipoprotein CIII in apoB containing lipoproteins (117.7+/-42.2 vs 22.6+/-23.9 g/L, p<0.005). LD subjects exhibited an insulin resistant as observed by higher HOMA (3.44+/-1.62 vs 1.60+/-0.61, p<0.05). They exhibited an increase in VLDL (1.24+/-0.33 vs 0.80+/-0.21 mg/kg/h, p<0.05), decrease in IDL (0.20+/-0.10 vs 0.48+/-0.24 mg/kg/h, p<0.05) and no difference in LDL (0.38+/-0.19 vs 0.45+/-0.25 mg/kg/h) production rate. LD subject also showed a dramatic decrease in transformation of VLDL to IDL (0.013+/-0.010 vs 0.258+/-0.206 h(-1), p<0.005) and IDL to LDL (0.088+/-0.093 vs 0.366+/-0.189 h(-1), p<0.05) and a decrease in fractional catabolic rate (FCR) of VLDL (0.199+/-0.132 vs 0.555+/-0.398 h(-1), p<0.05), IDL (0.110+/-0.08 vs 0.523+/-0.275 h(-1), p<0.05) and LDL (0.010+/-0.005 vs 0.025+/-0.014 h(-1), p<0.05). These disturbances, overproduction and an overall delayed catabolism of apoB, are similar to those observed using the same protocol in insulin resistant subjects. Our study suggests that metabolic disturbance of apoB100 observed in lipodystrophic HIV in combined antiretroviral therapy are consecutive to insulin resistance induced by the treatment.

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“…Comme l'utilisation des microbilles en tant qu'outil de calibrage fournit des valeurs absolues comparables d'un laboratoire à l'autre, leurs utilisations en biologie clinique suscitent beaucoup d'intérêt. Ainsi, au laboratoire, cette méthode de quantification antigénique par cytométrie en flux a été utilisée avec succès pour évaluer la modulation de l'expression des récepteurs des lipoprotéines de faible densité exprimés par les monocytes circulants à la fois chez des sujets infectés par le virus de l'immuodéficience humaine recevant des antirétroviraux [23] et chez des diabétiques de type 2 soumis à une insulinothérapie [8].…”

Section: Microbilles Cytométrie En Flux Et Quantification Antigéniqueunclassified

Cytométrie en flux, microbilles et analyses biomoléculaires multiplexes

Montange

Véjux

Labenne³

et al. 2005

Immuno-analyse & Biologie Spécialisée

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LDL‐receptors expression in HIV‐infected patients: relations to antiretroviral therapy, hormonal status, and presence of lipodystrophy

Abstract: HIV-lipodystrophy is associated with a lower expression of LDL-R. This decreased expression of LDL-R seems independent of DHEA or insulin secretion.

Cited by 28 publications

References 29 publications

The Impact of Dietary Iodine Intake on Lipid Metabolism in Mice

The Impact of Dietary Iodine Intake on Lipid Metabolism in Mice

Disturbance of Apolipoprotein B100 Containing Lipoprotein Metabolism in Severe Hyperlipidemic and Lipodystrophic HIV Patients on Combined Antiretroviral Therapy: Evidences of Insulin Resistance Effect

Cytométrie en flux, microbilles et analyses biomoléculaires multiplexes

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