LDL Receptor-Related Protein Plays An Essential Role In 12/15-Lipoxygenase-Mediated LDL Oxidation By Macrophages

Reactive Oxygen Species (ROS) Mediate p300-dependent STAT1 Protein Interaction with Peroxisome Proliferator-activated Receptor (PPAR)-γ in CD36 Protein Expression and Foam Cell Formation

“…Many studies have reported that 15-LO mediates LDL oxidation (55,56) and 15-LO products possess the prooxidant activity (57). Based on all these observations, it appears that 15(S)-HETE by producing ROS triggers a plethora of events, including inflammation via induction of expression of proinflammatory cytokines such as IL-6 (58) and IL-17A (59), chemokines such as MCP1 (60), endothelial cell dysfunction via phosphorylation of TJ proteins and TJ disruptions (52)(53)(54), and foam cell formation via LDL oxidation (55,56) and CD36 expression (24) may play quite an important role in atherogenesis.…”

Nitric oxide, peroxynitrite and lipoxygenase in atherogenesis: mechanistic insights

“…Interestingly, established lesions contain oxidized lipids that have lost their stereospecificity, indicating non-enzymatic lipid peroxidation occurs later in atherosclerosis progression (Kuhn et al, 1994(Kuhn et al, , 1997. Following from this work, several groups examined mechanisms and consequences of free and cell-expressed LOX oxidation of LDL, and found that this process formed a high-uptake LDL form, similar to that found in atherosclerotic lesions, and that this requires LDL receptor related protein, and can be enhanced by angiotensin II, lipoprotein lipase and secretory phospholipase A 2 (Scheidegger et al, 1997;Sigari et al, 1997;Belkner et al, 1998;Neuzil et al, 1998;Xu et al, 2003;Zhu et al, 2003).…”