LDL-Migration Index (LDL-MI), an Indicator of Small Dense Low-Density Lipoprotein (sdLDL), Is Higher in Non-Alcoholic Steatohepatitis than in Non-Alcoholic Fatty Liver: A Multicenter Cross-Sectional Study

Imajo, Kento; Hyogo, Hideyuki; Yoneda, Masato; Honda, Yoshihiro; Kessoku, Takaomi; Tomeno, Wataru; Ogawa, Yasuhiro; Taguri, Masataka; Mawatari, Hironori; Nozaki, Yuichi; Fujita, Koji; Kohno, Hiroyuki; Saito, Satoru; Sumida, Yoshio; Ono, Masafumi; Wada, Koichiro; Nakajima, Atsushi; Eguchi, Yuichiro

doi:10.1371/journal.pone.0115403

Cited by 40 publications

(37 citation statements)

References 52 publications

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“…To date, however, no studies have investigated whether the severity of coronary artery lesions differs between patients with NAFL or NASH. We previously reported that the low-density lipoprotein (LDL)-migration index (MI), an indicator of serum small dense LDL (sdLDL) concentration, is higher in patients with NASH than in those with NAFL, which corresponds to the alterations in lipid metabolism involved, and this suggests that the risk of atherosclerotic diseases may be higher in patients with NASH than in those with NAFL [13,14]. Therefore, we hypothesized that there is a higher risk of coronary artery disease (CAD) in patients with NASH than in those with NAFL.…”

Section: Introductionmentioning

confidence: 99%

Coronary Artery Disease is More Severe in Patients with Non-Alcoholic Steatohepatitis than Fatty Liver

et al. 2020

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Non-alcoholic fatty liver disease (NAFLD) is associated with a higher risk of atherosclerotic disease. However, the relationships between the severity of coronary atherosclerosis and pathologic findings in patients with NAFLD remain unknown. We aimed to characterize the coronary artery lesions in patients with NAFLD using coronary computed tomography angiography (CCTA). Overall, 101 patients with liver biopsy-proven NAFLD who had chest pain or electrocardiographic abnormalities underwent CCTA. Coronary artery lesions, including coronary artery stenosis (CAS), calcium score (CACS, Agatston score), and coronary artery non-calcified plaque were assessed using multi-slice CT. Multivariate analysis showed that age, smoking status, prevalence of dyslipidemia (DLP) and non-alcoholic steatohepatitis (NASH), and stage of fibrosis were independent risk factors for CAS. Age, and the prevalence of DM and DLP, were independent risk factors for CACS, and the prevalence of NASH tended to be an independent risk factor. In addition, the prevalence of DLP and NASH were independent risk factors for non-calcified plaques. Coronary artery lesions are more common in patients with NASH than in those with non-alcoholic fatty liver, suggesting a higher risk in patients with NASH. Therefore, patients with NASH should be closely followed, with particular vigilance for coronary artery diseases.

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Section: Introductionmentioning

confidence: 99%

Coronary Artery Disease is More Severe in Patients with Non-Alcoholic Steatohepatitis than Fatty Liver

et al. 2020

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“…Compared with simple steatosis, nonalcoholic steatohepatitis (NASH) patients have increased levels of sdLDL that may, at least partly, explain the increased risk for atherosclerosis and cardiovascular diseases in these patients [16 & ]. In this context, LDL migration index, an indicator of sdLDL, was higher in patients with NASH compared with those with nonalcoholic fatty liver diseases [17].…”

Section: Predictive Role Of Small Dense Ldlmentioning

confidence: 84%

Small, dense LDL

Gerber

Nikolić

Rizzo

2017

Current Opinion in Cardiology

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“…We conducted a PubMed search and three scientific papers were retrieved from the database as of the end of March 2020. All of these studies showed that LDL-c was associated with NAFLD [24,31,32] . Sun D-Q, Wu S-J,Liu W-Y, et al found that LDL-c was associated with NAFLD in the non-obese Chinese population in a cross-sectional and longitudinal study [31,32] .…”

Section: Discussionmentioning

confidence: 99%

“…One meta-analysis reports that it is the relatively high prevalence of NAFLD found in the Asian population (27%) [9][10][11] . The prevalence rate of NAFLD in the general population of China varies from 24.77-43.91% in recent years [11,12] .…”

Section: Introductionmentioning

confidence: 99%

“…Dyslipidemia is a comorbidity of NAFLD, which can lead to hypertriglyceridaemia, reductions in highdensity lipoprotein cholesterol (HDL-c), an increase in the size of very low-density lipoprotein and lowdensity lipoprotein cholesterol (LDL-c) [22] . In addition, more and more studies have shown that LDL-c is involved in the development of NAFLD and non-alcoholic steatohepatitis (NASH) [23][24][25] . This mechanism is still unclear, but insulin resistance and disorders of fat and sugar metabolism may explain some reasons [26][27][28] .…”

Section: Introductionmentioning

confidence: 99%

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Low-density lipoprotein cholesterol within the normal range and nonalcoholic fatty liver disease in the non-obese Chinese population: a secondary analysis based on a cross-sectional study

Zhigang¹,

Xu²,

Xu³

2020

Preprint

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Background Evidence regarding the relationship between normal low-density lipoprotein cholesterol (LDL-c) levels and non-alcoholic fatty liver disease (NAFLD) was limited. Therefore, this dissertation seeks to investigate the relationship between LDL-c and NAFLD in the non-obese Chinese population after adjusting for other covariates. Methods The present study was a cross-sectional study. A total of 183903 non-obese participants were involved in a Wenzhou Medical Center of Wenzhou People’s Hospital from 2010 to 2014. The target independent variable and the dependent variable were LDL-c measured at baseline and NAFLD respectively. Covariates involved in this study included SEX, AGE, BMI, SBP, DBP, FPG, ALB, ALT, AST, BUN, Cr, TG, TC, HDL-c, UA. It was noted that the entire study was completed by Dan-Qin Sun et al., and uploaded the data to the DATADRYAD website. The author only used this data for secondary analysis. Results The average age of 183903 selected participants was 41.0 ± 14.1 years old,and about 49.6% of them was male. After adjusting potential confounders (SEX, AGE, BMI, FPG, ALB, GLB, ALT, AST, GGT, BUN, Cr, TG, TC, HDL-c, UA), non-linear relationship was detected between normal LDL-c levels and NAFLD, whose point was 1.51. The effect sizes and the confidence intervals on the left and right sides of inflection point were 0.87 (0.64, 1.18) and 1.79 (1.67, 1.92), respectively. Conclusion The relationship between normal LDL-c levels and NAFLD is non-linear. Normal LDL-c levels was positively correlated with NAFLD when LDL-c was more than 1.51.

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LDL-Migration Index (LDL-MI), an Indicator of Small Dense Low-Density Lipoprotein (sdLDL), Is Higher in Non-Alcoholic Steatohepatitis than in Non-Alcoholic Fatty Liver: A Multicenter Cross-Sectional Study

Cited by 40 publications

References 52 publications

Coronary Artery Disease is More Severe in Patients with Non-Alcoholic Steatohepatitis than Fatty Liver

Coronary Artery Disease is More Severe in Patients with Non-Alcoholic Steatohepatitis than Fatty Liver

Small, dense LDL

Low-density lipoprotein cholesterol within the normal range and nonalcoholic fatty liver disease in the non-obese Chinese population: a secondary analysis based on a cross-sectional study

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