LDL-C/HDL-C is Associated With Ischaemic Stroke in Patients With Non-Valvular Atrial Fibrillation: A Case-Control Study

Abstract

Background This study explored relationships between low-/high-density lipoprotein cholesterol ratio (LDL-C/HDL-C) and other clinical indicators and ischaemic stroke (IS) in non-valvular atrial fibrillation (NVAF) patients in Xinjiang, which could provide a theoretical and therapeutic basis for patients with NVAF. Methods NVAF patients who were admitted to 10 medical centres across Xinjiang were divided into the stroke (798 patients) and control (2671 patients) groups according to whether acute IS occurred. Univariate and multivariate logistic regression analysis was used to examine the independent risk factors for IS in NVAF patients. We used factor analysis and principal component regression analysis to analyse the main influencing factors of IS. Receiver operating characteristic (ROC) curve analysis was used to evaluate the optimal cut-off value of LDL-C/HDL-C in predicting IS. Results Multivariate logistic regression showed that the risk of IS in the highest quartile of LDL-C/HDL-C (≥ 2.73) was 16.23-fold that in the lowest quartile (< 1.22); IS risk was 2.27-fold higher in obese patients (BMI ≥ 28 kg/m2) than in normal-weight subjects; IS risk was 3.15-fold higher in smoking than in non-smoking patients. The area under the ROC curve of LDL-C/HDL-C was 0.76, optimal critical value was 2.33, sensitivity was 63.53%, and specificity was 76.34%. Principal component regression analysis showed that LDL-C/HDL-C, age, smoking, drinking, LDL-C and hypertension were risk factors for IS in NVAF patients. Conclusions LDL-C/HDL-C > 1.22, smoking and BMI ≥ 24 kg/m2 were independent risk factors for IS in NVAF patients, of which LDL-C/HDL-C was the main risk factor.

LDL/HDL cholesterol ratio is associated with new-onset NAFLD in Chinese non-obese people with normal lipids: a 5-year longitudinal cohort study

“…These lipoproteins have been recommended for screening people with a high risk of NAFLD in clinical practice [18]. Recently, some studies have pointed out that the LDL/HDL cholesterol ratio can simultaneously evaluate LDL cholesterol and HDL cholesterol, and its performance in predicting the risk of cardiovascular and cerebrovascular metabolic-related diseases is better than that of a single lipoprotein [19][20][21]. At present, there are no research data on the association between NAFLD and the LDL/HDL cholesterol ratio.…”

LDL-C/HDL-C and carotid plaques in patients with coronary heart disease: A Chinese cohort study

“…Studies have shown that peripheral vascular atherosclerosis severely affects the most signi cantly prediction-related for deadliness and death of CVD. It has been reported that when the conventional lipid parameters triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and total cholesterol (TC) remain apparently normal, other lipids such as lipid ratios, including TC/HDL-C, LDL-C/HDL-C, TG/HDL-C, and non-HDL-C/HDL-C are the diagnosticate alternatives that have been shown to predict the risk of a cardiovascular event [3][4][5] . Studies have shown LDL-C that plays a key role in the pathogenesis of AS.…”