LCN2: Versatile players in breast cancer

Bao, Yuxiang; Yan, Zhongliang; Shi, Nianmei; Tian, Xiaoyan; Li, Jiayang; Li, Taolang; Cheng, Xiaoming; Lv, Junyuan

doi:10.1016/j.biopha.2023.116091

Cited by 2 publications

(1 citation statement)

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“…Furthermore, several studies have demonstrated a correlation between LCN2 and BCa histological grade, disease relapse, metastasis, poor prognosis, and ER-negative status. In addition, compared to controls, patients with an invasive BCa diagnosis had higher serum levels of LCN2 ( Bao et al, 2024 ). A study by Brian G. Drew et al showed that fat-specific estrogen receptors alpha (ERα) deletion led to enhanced adipocyte size, fat pad weight, tissue expression, and circulating levels of released LCN2 in mice.…”

Section: Adipokines and Breast Cancermentioning

confidence: 99%

Exploring the multifaceted role of obesity in breast cancer progression

Kakkat,

Suman,

Turbat- Herrera

et al. 2024

Front. Cell Dev. Biol.

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Obesity is a multifaceted metabolic disorder characterized by excessive accumulation of adipose tissue. It is a well-established risk factor for the development and progression of breast cancer. Adipose tissue, which was once regarded solely as a passive energy storage depot, is now acknowledged as an active endocrine organ producing a plethora of bioactive molecules known as adipokines that contribute to the elevation of proinflammatory cytokines and estrogen production due to enhanced aromatase activity. In the context of breast cancer, the crosstalk between adipocytes and cancer cells within the adipose microenvironment exerts profound effects on tumor initiation, progression, and therapeutic resistance. Moreover, adipocytes can engage in direct interactions with breast cancer cells through physical contact and paracrine signaling, thereby facilitating cancer cell survival and invasion. This review endeavors to summarize the current understanding of the intricate interplay between adipocyte-associated factors and breast cancer progression. Furthermore, by discussing the different aspects of breast cancer that can be adversely affected by obesity, this review aims to shed light on potential avenues for new and novel therapeutic interventions.

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Section: Adipokines and Breast Cancermentioning

confidence: 99%