LC3-associated phagocytosis is impaired in monocyte-derived macrophages from systemic sclerosis patients
Quentin Frenger,
Julie Lucas,
Arthur Petitdemange
et al.
Abstract:Autophagy is a fundamental catabolic process performed by a network of autophagy related (ATG) proteins. Some ATG proteins coordinate parallel roles in so-called “noncanonical” autophagy such as LC3-associated phagocytosis (LAP). Both autophagy and LAP share key functions in immunity and inflammation and have been linked to autoimmune diseases. Systemic sclerosis (SSc) is an autoimmune disease of unknown etiology characterized by excessive fibrosis in skin and multiple internal organs linked with an aberrant i… Show more
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