LC–NMR and LC–MS identification of an impurity in a novel antifungal drug icofungipen

NMR Spectroscopy for Studying Interactions of Bioactive Molecules

“…In modern drug discovery, NMR provides much more than macromolecular 3D structure determination since it has found widespread use in hit and lead generation, metabonomics and complex mixture analysis. Excellent discussions of the principles and applications of NMR techniques in metabonomics and mixture analysis can be found in a number of books and articles [14][15][16][17][18][19][20][21].…”

Identification in drug quality control and drug research

“…A typical example is the identification of impurities in bis-indol alkaloids vinblastine and vincristine [26]. Due to the high cost of the necessary instruments and some other problems [20,27], the fully on-line approach [HPLC-(UV)-MS/(MS) and LC-NMR] is used relatively infrequently {e.g., the identification of an N-cinnamyl impurity in icofungipen [28]}.…”

A critical review on the use of modern sophisticated hyphenated tools in the characterization of impurities and degradation products

“…More specific applications of 1D and 2D LC-NMR in understanding inherent degradation behavior of APIs and the formation of DPs in formulations were critically described by Pan et al [103]. There are several other reports on the use of LC-NMR for structural characterization of IMPs and degradation/interaction products [39,122,153,168,[225][226][227][228][229][230][231][232][233][234][235][236][237][238][239][240][241][242]. A compilation is separately given in Table S4, which includes details of drugs/compounds investigated, IMPs/DPs characterized, their amount in the sample, instrument configuration, operation mode, etc.…”