LC/MS Studies on Characterization and Determination of N,N′-Ethylenebisdithiocarbamate Fungicides in Environmental Water Samples

Hanada, Yoshifumi; Tanizaki, Teizi; Koga, Minoru; Shiraishi, Hiroaki; Soma, Mitsuyuki

doi:10.2116/analsci.18.441

Cited by 35 publications

(14 citation statements)

References 5 publications

(5 reference statements)

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“…The majority of reported methods for determining EBDCs are based on the quantification of carbon disulfide [5][6][7][8] or ethylenediamine using different techniques [9][10][11]. Several attempts have been made to analyze EBDCs by liquid chromatography (LC) using UV [6,12,13], electrochemical [14], and, more recently, mass spectrometry detectors [15]. However, all these methods require derivatization steps, and most of them are insufficiently specific to distinguish between residues of individual EBDCs.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of maneb and its main metabolites in tomatoes by liquid chromatography using diode array ultraviolet absorbance detection

Martínez

Fernández-Hernando

Cámara

2004

Journal of Chromatography A

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Section: Introductionmentioning

confidence: 99%

Simultaneous determination of maneb and its main metabolites in tomatoes by liquid chromatography using diode array ultraviolet absorbance detection

Martínez

Fernández-Hernando

Cámara

2004

Journal of Chromatography A

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“…In this case, the addition of a conventional EDTA solution [12][13][14][15][16][17][21][22][23][24][25] was not appropriate, as the LC-MS/MS peak corresponding to EDTA overlapped with the peak originating from PBMe. We therefore investigated the effect of the NaHCO 3 concentration on the sample prior to methylation, using propineb, mancozeb, and thiuram as representative compounds for PB, EB, and DD, respectively, as previously mentioned.…”

Section: Optimization Of the Sample-preparation Methodsmentioning

confidence: 99%

“…Thus, we attempted to prevent degradation by adding DTT as a stabilizer, as it has been reported that reducing agents are effective stabilizers. 26) In this case, we could not select cysteine, [12][13][14][15][16][17][22][23][24][25] as the retention times for the methylated form of cysteine and DDMe were comparable under the same MS/MS conditions due to their similar molecular weights. Thus, we also investigated the effect of the DTT concentration on the samples and found that degradation was prevented in a number of cases, resulting in enhanced methylation rates.…”

Section: Optimization Of the Sample-preparation Methodsmentioning

confidence: 99%

A rapid and sensitive analysis of dithiocarbamate fungicides using modified QuEChERS method and liquid chromatography–tandem mass spectrometry

Kakitani

Yoshioka

Nagatomi

et al. 2017

Journal of Pesticide Science

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We herein present a method for the analysis of 10 dithiocarbamate fungicides (DTCs) in beer, fruit juice, and malt samples, where the DTCs were converted into water-soluble sodium salts in the presence of NaHCO 3 prior to methylation using dimethyl sulfate. Extraction of the methylated compounds from matrices was performed using a "quick, easy, cheap, effective, rugged, and safe" (QuEChERS) method. Following a dispersive solid-phase extraction as a clean-up step, the methylated compounds were detected by liquid chromatography-tandem mass spectrometry. Performance evaluation was carried out on beer, fruit juice, and malt samples using representative compounds. Accuracies of the spiked compounds from the various matrices ranged from 92.2 to 112.6%, and the limits of quantification of propineb, mancozeb, and thiuram were <0.52, <0.55, and <6.97 µg/kg, respectively. The developed method was then applied in the determination of dithiocarbamate fungicide contents in commercial beer and fruit juice samples.

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“…N,N′-ethylenebisdithiocarbamate fungicides -used as zinc or manganese salts (manzeb, maneb and zineb) -were transformed to their sodium salts, extracted as ion pairs with tetrabutylammonium, S-alkylated with methyl iodide, and determined by LC-ESI-MS in the ng/L range [100].…”

Section: Pesticidesmentioning

confidence: 99%

LC-MS analysis in the aquatic environment and in water treatment technology ? a critical review

Zwiener

Frimmel

2004

Analytical and Bioanalytical Chemistry

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Environmental contaminants of recent concern are pharmaceuticals, estrogens and other endocrine disrupting chemicals (EDC) such as degradation products of surfactants, algal and cyanobacterial toxins, disinfection by-products (DBPs) and metalloids. In addition, pesticides (especially their transformation products), microorganisms, and humic substances (HS), in their function as vehicles for contaminants and as precursors for by-products in water treatment, traditionally play an important role. The present status of the application of LC-MS techniques for these water constituents are discussed and examples of application are given. Solid-phase extraction with various non-selective materials in combination with liquid chromatography (LC) on reversed-phase columns have been the most widely used methods for sample preconcentration and separation for different compound classes like pesticides, pharmaceuticals or estrogens. Electrospray ionization (ESI) and atmospheric pressure ionization (APCI) are the most frequently used ionization techniques for polar and ionic compounds, as well as for less polar non-ionic ones. The facilities of LC-MS have been successfully demonstrated for different compound classes. Polar compounds from pharmaceuticals used as betablockers, iodinated X-ray contrast media, or estrogens have been determined without derivatization down to ultratrace concentrations. LC-MS can be viewed as a prerequisite for the determination of algal and cyanobacterial toxins and the homologues and oligomers of alkylphenol ethoxylates and their metabolites. Tandem mass spectrometric techniques and the use of diagnostic ions reveal their usefulness for compound-class specific screening and unknown identification, and are also valid for the analysis of pesticides and especially for their transformation products. Structural information has been gained by the application of LC-MS methods to organometallic species. New insights into the structural variety of humic substances have been made possible by FT-ICR-MS due to its ultrahigh mass resolution. Finally, exciting possibilities for rapid detection and identification of microorganisms have been made possible by MALDI and LC-MS methods.

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LC/MS Studies on Characterization and Determination of N,N′-Ethylenebisdithiocarbamate Fungicides in Environmental Water Samples

Cited by 35 publications

References 5 publications

Simultaneous determination of maneb and its main metabolites in tomatoes by liquid chromatography using diode array ultraviolet absorbance detection

Simultaneous determination of maneb and its main metabolites in tomatoes by liquid chromatography using diode array ultraviolet absorbance detection

A rapid and sensitive analysis of dithiocarbamate fungicides using modified QuEChERS method and liquid chromatography–tandem mass spectrometry

LC-MS analysis in the aquatic environment and in water treatment technology ? a critical review

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