LC/MS of the soft coral Sarcophyton ehrenbergi and its isolated associated endophytic fungi: Aspergillus oryzae and Aspergillus flavus

Elkhawas, YA; Mostafa, N.H.; Elissawy, AM; Alnaggar,; Kamal, EM; Bishr, MM; Singab, Anb; Salama, OM

doi:10.1055/s-0039-3399901

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“…Figure 2 illustrates the secondary metabolites isolated from Aspergillus flavus . Additionally, LC-MS analysis of the ethyl acetate extract of A. flavus associated with the soft coral Sarcophyton ehrenbergi led to the identification of seven compounds, namely, asperorydine B (66), 4-methyl-5,6-dihydro-2H-pyran-2-one (67), speradine A (53), maltoryzine (68), aflatoxine B1, asperorydine G (69), and asperorydine M (70) [ 34 ], ( Figure 3 ).…”

Section: Biological Activity and Secondary Metabolites Obtained Frmentioning

confidence: 99%

An Updated Review on the Secondary Metabolites and Biological Activities of Aspergillus ruber and Aspergillus flavus and Exploring the Cytotoxic Potential of Their Isolated Compounds Using Virtual Screening

Youssef

Singab

2021

Evidence-Based Complementary and Alternative Medicine

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The secondary metabolites and biological activities of Aspergillus ruber and Aspergillus flavus were comprehensively reported. About 70 compounds were isolated from both species that belong to different classes using conventional and advanced chromatographic techniques and unambiguously elucidated employing one- and two-dimensional nuclear magnetic resonance (1D and 2D NMR) and high resolution mass spectrometry (HRMS). Some of them displayed promising antiviral, anti-inflammatory, and antioxidant activities. In silico studies were conducted on human cyclin-dependent kinase 2 (CDK-2), human DNA topoisomerase II (TOP-2), and matrix metalloprotinase 13 (MMP-13) in an effort to explore the cytotoxic potential of the diverse compounds obtained from both Aspergillus species. 1,6,8-Trihydroxy-4-benzoyloxy-3-methylanthraquinone (23) revealed the most firm fitting with the active pockets of CDK-2 and MMP-13; meanwhile, variecolorin H alkaloid (14) showed the highest fitting within TOP-2 with ∆G equals to −36.51 kcal/mole. Thus, fungal metabolites could offer new drug entities for combating cancer. Relevant data about both Aspergillus species up to August 2020 were gathered from various databases comprising Scifinder (https://scifinder.cas.org/scifinder/login) for secondary metabolite-related studies; meanwhile, for biology-related articles, data were collected from both PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) and Web of Knowledge (http://www.webofknowledge.com) as well.

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Section: Biological Activity and Secondary Metabolites Obtained Frmentioning

confidence: 99%

An Updated Review on the Secondary Metabolites and Biological Activities of Aspergillus ruber and Aspergillus flavus and Exploring the Cytotoxic Potential of Their Isolated Compounds Using Virtual Screening

Youssef

Singab

2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

LC/MS of the soft coral Sarcophyton ehrenbergi and its isolated associated endophytic fungi: Aspergillus oryzae and Aspergillus flavus

Cited by 1 publication

References 0 publications

An Updated Review on the Secondary Metabolites and Biological Activities of Aspergillus ruber and Aspergillus flavus and Exploring the Cytotoxic Potential of Their Isolated Compounds Using Virtual Screening

An Updated Review on the Secondary Metabolites and Biological Activities of Aspergillus ruber and Aspergillus flavus and Exploring the Cytotoxic Potential of Their Isolated Compounds Using Virtual Screening

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