LC–MS/MS based studies on the anti-depressant effect of hypericin in the chronic unpredictable mild stress rat model

Zhai, Xuejia; Chen, Fen; Chen, Chen; Zhu, Chengliang; Lu, Yongning

doi:10.1016/j.jep.2015.04.053

Cited by 41 publications

(21 citation statements)

References 32 publications

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“…The rats in the stress group gained less body weight than the rats in the control group, but there was no statistical difference between the AS, fluoxetine, and model groups. These results are in line with some studies, while others have shown that antidepressants can reverse body weight gain when results are compared to the stress-only group [33–35]. …”

Section: Discussionsupporting

confidence: 91%

The Antidepressant Effect of Angelica sinensis Extracts on Chronic Unpredictable Mild Stress‐Induced Depression Is Mediated via the Upregulation of the BDNF Signaling Pathway in Rats

Shen

Zhang

Deng

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Angelica sinensis (AS), a traditional Chinese herbal medicine, has pharmaceutical effects on menstrual illness, cerebrovascular diseases, cardiovascular diseases, and cognitive impairments. However, until recently, few studies had explored its antidepressant effect. The current study attempts to investigate the effect of AS extracts on chronic unpredictable mild stress- (CUMS-) induced depression in rats. Male SD rats were exposed to a CUMS-inducing procedure for 5 weeks, resulting in rodent depressive behaviors that included reduced sucrose consumption and lessened sucrose preference ratios in sucrose preference test, prolonged immobility times and decreased struggling time in force swim test, and decreased locomotor activity in open field test. Moreover, the expression of brain derived neurotrophic factor (BDNF) and the phosphorylation of cAMP-response element binding protein (CREB) and extracellular signal-regulated protein kinase (ERK 1/2) were markedly decreased in the hippocampus in depressed rats. However, chronically treating the depressed rats with AS (1 g/kg) normalized their depression-related behaviors and molecular profiles. In conclusion, in the present study, we show that AS extracts exerted antidepressant effects that were mediated by the BDNF signaling pathway: in AS-treated depressed rats, the expression of the BDNF protein and the phosphorylation of its downstream targets (ERK 1/2, CREB) were upregulated in the hippocampus.

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Section: Discussionsupporting

confidence: 91%

The Antidepressant Effect of Angelica sinensis Extracts on Chronic Unpredictable Mild Stress‐Induced Depression Is Mediated via the Upregulation of the BDNF Signaling Pathway in Rats

Shen

Zhang

Deng

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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show abstract

“…Additionally, SJW contains the phenolcarbon acids caffeic acid and chlorogenic acid as well as proanthocyanidins, tannins, etheric oils, fatty acids and chlorophyllin [8]. Pharmacological activity was evident for hypericin [9,10]. However, high doses of pure hypericin were necessary for reaching pharmacological activity, which can be barely achieved by administration of total SJW extract due to the low water solubility of hypericin.…”

Section: Introductionmentioning

confidence: 99%

Sustained Release for St. John?s Wort: A Rational Idea?

Disch¹,

Forsch²,

Siewert³

et al. 2017

J Bioequiv Availab

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“…The results indicated that similar to antidepressants, oral administration of MEPS prevented the development of anxiety/depressant-like behaviors in CUMS rats. Bodyweight gain was used to examine the ability of free water and food intake in rats (25). TST and FST are widely used as a reliable animal model of depression to screen novel antidepressants (26).…”

Section: Discussionmentioning

confidence: 99%

Antidepressant-like effects of Marasmius androsaceus metabolic exopolysaccharides on chronic unpredictable mild stress-induced rat model

Song

Wang

Huang

et al. 2017

Molecular Medicine Reports

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Marasmius androsaceus (M. androsaceus), a medicinal fungus, has various pharmacological activities including antidepression. The present study investigated the effects of exopolysaccharides obtained during M. androsaceus submerged fermentation in a chronic unpredictable mild stress (CUMS)‑induced depression rat model. Similar to fluoxetine (positive drug), 4‑week administration of M. androsaceus exopolysaccharides (MEPS) at doses of 6, 30 and 150 mg/kg strongly enhanced bodyweight gain and sucrose consumption, and reduced the immobility time in forced swimming test and tail suspension test in CUMS rats. MEPS resulted in significant enhancement on the levels of noradrenalin, dopamine, 5‑hydroxytryptamine (5‑HT), and 5‑hydroxyindoleacetic acid in the serum and hypothalamus of CUMS rats, as detected by ELISA. Western blotting results revealed that MEPS upregulated the protein expression levels of tyrosine hydroxylase in the hypothalamus of CUMS rats. In conclusion, these results confirmed the antidepressant‑like effects of MEPS, and suggested that the monoamine neurotransmitter system is involved in its antidepressive effects in a CUMS rat model. The present study provided evidence for the clinical application of MEPS as an effective agent against depression.

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LC–MS/MS based studies on the anti-depressant effect of hypericin in the chronic unpredictable mild stress rat model

Cited by 41 publications

References 32 publications

The Antidepressant Effect of Angelica sinensis Extracts on Chronic Unpredictable Mild Stress‐Induced Depression Is Mediated via the Upregulation of the BDNF Signaling Pathway in Rats

The Antidepressant Effect of Angelica sinensis Extracts on Chronic Unpredictable Mild Stress‐Induced Depression Is Mediated via the Upregulation of the BDNF Signaling Pathway in Rats

Sustained Release for St. John?s Wort: A Rational Idea?

Antidepressant-like effects of Marasmius androsaceus metabolic exopolysaccharides on chronic unpredictable mild stress-induced rat model

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