LC–MS/MS based method development for the analysis of florfenicol and its application to estimate relative distribution in various tissues of broiler chicken

Imran, Muhammad; Fazal-e-Habib,; Tawab, Abdul; Rauf, Waqar; Rahman, Md Jamilur; Khan, Qaiser Mehmood; Asi, Muhammad Rafique; Iqbal, Mazhar

doi:10.1016/j.jchromb.2017.08.029

Cited by 27 publications

(16 citation statements)

References 20 publications

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“…For APs extraction, meat tissues have been mixed with different solutions such as HCl (Saito‐Shida, Shiono, Narushima, Nemoto, & Akiyama, 2019), HCl combined with ethyl acetate (Anderson et al., 2016; Imran et al., 2017; Zhou et al., 2020), HCl with MeOH (Zhang et al., 2017), PBS with ethyl acetate (Fahim et al., 2018; Nasim et al., 2016) or with MeOH (Kikuchi et al., 2017), organic solvents such as ACN (Y. Wang et al., 2017) or ACN combined with formic acid (Amelin & Korotkov, 2017; Rezaee & Khalilian, 2018) and ethyl acetate (Barreto et al., 2016; Imran et al., 2018; Wang et al., 2019). In addition, saline solutions, for instance, EDTA‐McIlvaine buffer (Jian et al., 2019; Rezaee & Khalilian, 2018), Na 2 SO 4 /MgSO 4 /NaCl (Kemokgatla, 2017), and Britton‐Robinson buffer with TCA (Rahimi et al., 2017) have been also employed.…”

Section: Analytical Methodologies For the Analysis Of The Principal Amentioning

confidence: 99%

“…In addition, saline solutions, for instance, EDTA‐McIlvaine buffer (Jian et al., 2019; Rezaee & Khalilian, 2018), Na 2 SO 4 /MgSO 4 /NaCl (Kemokgatla, 2017), and Britton‐Robinson buffer with TCA (Rahimi et al., 2017) have been also employed. Once in solution, some sample preparation treatments for purification and enrichment of APs including LLE (Barreto et al., 2016; Zhou et al., 2020), DLLME (Kemokgatla, 2017; Rezaee & Khalilian, 2018), traditional SPE (Anderson et al., 2016; Jian et al., 2019; Kikuchi et al., 2017; Rahimi et al., 2017; Rezaee & Khalilian, 2018; Saito‐Shida et al., 2019), DSPE (Imran et al., 2017; Zhang et al., 2017), DSPME (Y. Wang et al., 2017), and thin layer chromatography (TLC; Zhou et al., 2020) have been used.…”

Section: Analytical Methodologies For the Analysis Of The Principal Amentioning

confidence: 99%

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Determination of antibiotics in meat samples using analytical methodologies: A review

Moga

Vergara-Barberán

Lerma‐García

et al. 2021

Comp Rev Food Sci Food Safe

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Antibiotics are widely used to prevent or treat some diseases in human and veterinary medicine and also as animal growth promoters. The presence of these compounds in foods derived from food‐producing animals can be a risk for human health. Consequently, regulatory agencies have set maximum residue limits for antibiotics in food samples. Therefore, the development of novel methodologies for its determination in food samples is required. Specifically, the analysis and quantification of these substances in meat tissues is a challenge for the analytical chemistry research community. This is due to the complexity of the matrix and the low detection limits required by the regulatory agencies. In this sense, a comprehensive review on the development of new sample preparation treatments involving extraction, cleanup, and enrichment steps of antibiotics in meat samples in combination with sensitive and sophisticated determination techniques that have been carry out in the last years is necessary. Therefore, the aim of this work is to summarize the published methodologies for the determination of antibiotics from 2016 until the beginning of the second semester of 2020. The first part of this review includes an introduction about antibiotic families, followed by sample preparation and determination techniques applied to the different families. Finally, a detailed discussion of the current trends and the future possible perspectives in this field are also included.

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Section: Analytical Methodologies For the Analysis Of The Principal Amentioning

confidence: 99%

Section: Analytical Methodologies For the Analysis Of The Principal Amentioning

confidence: 99%

Determination of antibiotics in meat samples using analytical methodologies: A review

Moga

Vergara-Barberán

Lerma‐García

et al. 2021

Comp Rev Food Sci Food Safe

View full text Add to dashboard Cite

show abstract

“…The full scan of the antibiotics mixture in positive mode showed that the signal-to-noise ratios obtained in this mode were higher than those of the in negative mode. Hence, positive mode was used to obtain the precursor ion [M+H] for the qualitative and quantitative analysis [9,17,[28][29][30][31]. During the method development, the quadrupole mass analyzers operated in selected ion monitoring (SIM) mode where it monitors only a few mass-tocharge ratios.…”

Section: Lc-ms Soptimizationmentioning

confidence: 99%

“…However, the use of antibiotics is growing and their input to the aquatic environment is increasing making them of increasing environmental relevance. The increased awareness that synthetic drugs can lead to serious side effects in the environment has prompted researchers to launch several monitoring studies into the most commonly administered compounds in urban wastewater [17][18][19][20][21][22][23][24]. In this work, we developed and validated ESI.…”

Section: Introductionmentioning

confidence: 99%

ESI-LC/MS Method Development and Validation for the Determination of Some Selected Antibiotics in Hospital Wastewater

De¹,

Bs²,

Hassan³

et al. 2018

Pharm Anal Acta

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“…Some studies developed methodologies for the detection of phenicols in edible tissues of chicken. One of these methods [ 24 ] uses LC–MS/MS for the routine analysis of FF residues in this matrix and could also be applied to the analysis of liver samples. The same group of researchers adapted and revalidated a simple, short, and rapid confirmatory method for the simultaneous analysis of multi-amphenicol residues in poultry meat [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Residue Depletion of Florfenicol and Florfenicol Amine in Broiler Chicken Claws and a Comparison of Their Concentrations in Edible Tissues Using LC–MS/MS

et al. 2018

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Antimicrobial residues might persist in products and by-products destined for human or animal consumption. Studies exploring the depletion behavior of florfenicol residues in broiler chicken claws are scarce, even though claws can enter the food chain directly or indirectly. Hence, this study intended to assess the concentrations of florfenicol (FF) and florfenicol amine (FFA)—its active metabolite—in chicken claws from birds that were treated with a therapeutic dose of florfenicol. Furthermore, concentrations of these analytes in this matrix were compared with their concentrations in edible tissues at each sampling point. A group of 70 broiler chickens were raised under controlled conditions and used to assess residue depletion. Sampling points were on days 5, 10, 20, 25, 30, 35, and 40 after ceasing treatment, thus extending beyond the withdrawal period established for muscle tissue (30 days). Analytes were extracted using HPLC-grade water and acetone, and dichloromethane was used for the clean-up stage. Liquid chromatography coupled to mass spectroscopy detection (LC–MS/MS) was used to detect and quantify the analytes. The analytical methodology developed in this study was validated in-house and based on the recommendations described in the Commission Decision 2002/657/EC from the European Union. Analyte concentrations were calculated by linear regression analysis of calibration curves that were fortified using an internal standard of chloramphenicol-d5 (CAF-d5). The depletion time of FF and FFA was set at 74 days in claws, based on a 95% confidence level and using the limit of detection (LOD) as the cut-off point. Our findings show that FF and FFA can be found in chicken claws at higher concentrations than in muscle and liver samples at each sampling point.

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LC–MS/MS based method development for the analysis of florfenicol and its application to estimate relative distribution in various tissues of broiler chicken

Cited by 27 publications

References 20 publications

Determination of antibiotics in meat samples using analytical methodologies: A review

Determination of antibiotics in meat samples using analytical methodologies: A review

ESI-LC/MS Method Development and Validation for the Determination of Some Selected Antibiotics in Hospital Wastewater

Residue Depletion of Florfenicol and Florfenicol Amine in Broiler Chicken Claws and a Comparison of Their Concentrations in Edible Tissues Using LC–MS/MS

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