LC/MS-MS Analyses and in vitro anticancer activity of Tourneuxia variifolia extracts

Abstract

Several Saharan plants, despite their abundance of natural compounds, have received little attention. In this study, the chemical composition of polar extracts of Tourneuxia variifolia Coss.(Asteraceae), an endemic species to Algerian Sahara, was investigated and their anticancer activity was evaluated in vitro. The phytoconstituents of both ethyl acetate (EtOAc) and n-butanol (n-BuOH) extracts were screened using LC/MS-MS technique. The anticancer activity of the above extracts was measured against human cervical adenocarcinoma (HeLa) cell line. The LC/MS-MS analyses results revealed that twenty-seven phytochemicals in EtOAc extract and twenty-three in n-BuOH extract were identified and quantified from which isoquercetin and astragalin were the most present. Moreover; the EtOAc extract was found to have a strong anticancer activity (IC 50 : 46.797±0.060µg/mL). These findings identified T. variifolia as a potential plant exhibiting anticancer properties.

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“… •The EtOAc extract showed potent anticancer activity with IC50 of 46.797 ± 0.060 mg/mL. [ 309 ] 15 Tapinanthus sp. (Loranthaceae) •Methanol extract from leaves •Flavonoid glycoside (compound 3) Inhibit proliferation An in vitro study using glioblastoma (U87MG, C6) and prostate (PC-3) cancer cells •The methanol leaves extract exhibited great anticancer activity in U87 with IC50 of 21.40 mg/mL and PC-3 cells with IC50 of 10.26 mg/mL.…”