LC‐ESI‐QTOF‐MS for the Profiling of the Metabolites and in Vitro Enzymes Inhibition Activity of Bryophyllum pinnatum and Oxalis corniculata Collected from Ramechhap District of Nepal

Pandey, Bishnu Prasad; Pradhan, Shreekar; Adhikari, Kapil

doi:10.1002/cbdv.202000155

Cited by 17 publications

(5 citation statements)

References 55 publications

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“…Despite the growing number of studies describing pharmacological actions of Kalanchoe extracts, and the knowledge about flavonoids as important chemical constituents in this genus, most of the studies have just reported the presence of these molecules, without properly investigating their bioactive behavior. Indeed, several of these studies only suggest the potential role of flavonoids in a given activity [ 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 ], without assessing the isolated compound to confirm its bioactivity. The characterization of bioactive compounds is important not only to define the molecules responsible for a given biological property, but also for the development of phytomedicines.…”

Section: Main Classes Of Bioactive Compounds In Kalanchoe ...mentioning

confidence: 99%

Bioactive Compounds from Kalanchoe Genus Potentially Useful for the Development of New Drugs

Nascimento

Casanova

Costa

2023

Life

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The genus Kalanchoe Adans. (Crassulaceae) is native to Madagascar and comprises 145 species, being naturalized in the tropics and cultivated worldwide. In addition to having ornamental value, several Kalanchoe species are commonly used in popular medicine for the treatment of inflammatory conditions, wounds, gastric ulcers, and other diseases. The great importance of the genus is reflected on its acknowledgment by traditional and alternative health systems and organizations, as well as on the growing number of papers reporting pharmacological properties of extracts and isolated compounds from Kalanchoe. Among these properties, we highlight anti-inflammatory, antitumor, wound healing, antiulcer, and muscle relaxing properties. These activities are attributed mostly to flavonoids and bufadienolides, the main secondary metabolites reported in Kalanchoe extracts. While bufadienolides are generally related to cytotoxic and muscle relaxing activities, flavonoids are commonly reported as anti-inflammatory and wound healing agents. This review provides up to date information and perspectives on bioactive compounds from the Kalanchoe genus that are potentially useful for the development of new drugs. It includes not only a discussion on the advantages of the Kalanchoe species as source of bioactive compounds, but also the gaps, opportunities, and challenges to translate the acquired knowledge into innovation for drug development.

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Section: Main Classes Of Bioactive Compounds In Kalanchoe ...mentioning

confidence: 99%

Bioactive Compounds from Kalanchoe Genus Potentially Useful for the Development of New Drugs

Nascimento

Casanova

Costa

2023

Life

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“…Scavenging, Chlorophyll, and Carotenoid Contents. Te estimation of favonoids, phenolics, scavenging, and chlorophyll contents were done using standard protocols as done by various researchers [56][57][58].…”

Section: Estimation Of the Change In Flavonoid Phenolics Radicalmentioning

confidence: 99%

Non-Thermal Plasma: A Promising Technology for the Germination Enhancement of Radish (Raphanus sativus) and Carrot (Daucus carota sativus L.)

Guragain

Baniya

Shrestha

et al. 2023

Journal of Food Quality

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Cold plasma is an innovative and promising technology that is developing in a variety of fields, and recently it has been getting a lot of attention in the agricultural industry. The influence of cold atmospheric pressure plasma (CAPP) exposure on germination parameters and vigor of radish (Raphanus sativus) and carrot (Daucus carota sativus L.) seeds was investigated in the present study. A custom-designed plasma driver utilizing 11.32 kV rms and 50 Hz was used for the generation of the discharge. Seeds were treated using a dielectric barrier discharge (DBD) in an argon atmosphere at exposure periods of 1–4 minutes. The estimate of plasma parameters was done using optical emission spectroscopy and electrical measurements. Germination-related measures such as the final germination percentage, germination index, germination value, coefficient of velocity of germination, vigor index, and chlorophyll content were all improved in the case of CAPP-treated seeds as compared to control seeds. Similarly, CAPP treatment changed the in vitro radical scavenging capabilities, total phenolic, and total flavonoid levels of the seedlings. Our results indicated that the seeds being treated by CAPP for 3 minutes seemed to have a favorable impact on seed germination and sprouting development.

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“…Each serving had 7.76 mg of gallic acid equivalents and 6.92 mg of rutin equivalents, respectively, in the total phenol content. [16][17][18] The water extracts included a high concentration of tannins, palmitic acid, and a mixture of oleic, linoleic, linolenic, and stearic acids, while the alcoholic extract contained carbohydrates, glycosides, phytosterols, phenolic compounds, amino acids, and stearic acid. The sample also included calcium, fiber, and tannin, according to the research.…”

Section: Phytochemical Profilementioning

confidence: 99%

Untitled

2023

IJGP

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One of the most recent focal plant species in India is Oxalis corniculata Linn, often known as creeping woodsorrel and a member of the family Oxalidaceae. It is a native to tropical and subtropical areas of the globe and is significant in medicine. Several conventional medical practices have used the herb O. corniculata Linn. to cure human illnesses and afflictions. The review is designed to assess the publication based on the research review on O. corniculata. The literature for a decade from 2011 to 2021 was collected from scientific databases such as PubMed, PubMed Central, Scopus, Science Direct, and Google Scholar. A methodical search was performed using various keywords in order to get a deeper insight into the database. The review indicates that several phytochemical compounds, including flavonoids, tannins, phytosterols, phenol, glycosides, fatty acids, galacto-glycerolipids, and volatile oil, have been isolated from the plant. The leaves are rich in flavonoids, isovitexine, and vitexine-2"-Obeta-D-glucopyranoside. It is an abundant supply of important fatty acids such as palmitic acid, oleic acid, linoleic acid, linolenic acid, and stearic acid. The chemical structure of the identified compound given in the literature was sketched using the chem sketch freeware version, which would help the researchers to study the chemical nature of the compound in reference to identifying the lead molecule for further designing the semisynthetic derivatives with optimized activity. Also from the literature, it has been revealed that different parts of O. corniculata were assessed for pharmacological activities and found to possess antidiabetic activity, wound healing activity, antioxidants, anxiolytic properties, protective effect on induced nephrotoxicity, and antibacterial activity. The major focus of the review was to identify the folkloric uses of the plant that were reported in the published study. For a long time, traditional medicinal practitioners have used the plant to treat bad breath and is a rich source of Vitamin C for the treatment of Vitamin C deficiency for the treatment of stomach disorders in the area of the Cold Desert of Western Himalaya, Traditional healers from many locations reportedly used it to treat cataracts, sinusitis, conjunctivitis, and typhoid. The plant is utilized for athlete's foot, wounds, hypertension, diabetes, and hormonal imbalance; stomachache and migraine; excessive menstruation; cough; and poison antidote; as a blood tonic to be taken orally; intestinal gas; stomach discomfort; renal pain; kidney stone; and strengthening urinary tract wall; as a therapy for fractures and snakebites; as utilized to cure renal conditions; leaf paste to promote speedy healing; topically to cure worms and scorpion stings; and skin ailments; utilized to cure renal conditions; topically to cure worms; and scorpion stings; and skin ailments; therapeutic characteristics, such as astringent; and hemorrhoea.

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LC‐ESI‐QTOF‐MS for the Profiling of the Metabolites and in Vitro Enzymes Inhibition Activity of Bryophyllum pinnatum and Oxalis corniculata Collected from Ramechhap District of Nepal

Cited by 17 publications

References 55 publications

Bioactive Compounds from Kalanchoe Genus Potentially Useful for the Development of New Drugs

Bioactive Compounds from Kalanchoe Genus Potentially Useful for the Development of New Drugs

Non-Thermal Plasma: A Promising Technology for the Germination Enhancement of Radish (Raphanus sativus) and Carrot (Daucus carota sativus L.)

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