LC-ESI-QOrbitrap™ MS/MS within pesticide residue analysis in fruits and vegetables

Rajski, Łukasz; Bueno, María Jesús Martínez; Ferrer, Carmen María Salvador; Fernández‐Alba, Amadeo R.

doi:10.1016/j.trac.2019.06.032

Cited by 38 publications

(17 citation statements)

References 60 publications

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“…Formate ion (m/z 44.99820) was acquired in SIM MS mode. This acquisition mode provides higher sensitivity than full scan MS [ 37 ]. Formic acid did not provide any sensitive fragment in MS 2 mode.…”

Section: Resultsmentioning

confidence: 99%

Ion chromatography coupled to Q-Orbitrap for the analysis of formic and oxalic acid in beehive matrices: a field study

et al. 2022

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There is an increasing concern about the use of synthetic acaricides to fight the ectoparasitic mite Varroa destructor. Natural products such as formic acid (FA) and oxalic acid (OA) have emerged as a possible alternative control strategy. However, given the difficulty of analysing these highly polar compounds and the lack of robust and reliable methods, there are very few studies of the concentration and distribution of these natural acaricides in the beehive compartments. We present a reliable and simple analytical methodology, based on sample extraction with modified quick polar pesticide (QuPPe) methods followed by ion chromatography coupled to a quadrupole Orbitrap mass analyser for the analysis of FA and OA in honeybees, honey, beeswax, and beebread. The developed methods have been used in a field study for the evaluation of the presence and distribution of FA and OA in the beehive products, as well as in adult bees and bee brood samples, before, during, and up to 3 months after the application of the treatments by the beekeeper. Beebread and honey samples presented the highest concentration levels of OA and FA, respectively, mainly due to their natural presence. As expected, the organic acids showed low persistence in wax after the treatments. The natural acaricides were found in adult and developing bees at concentration levels below the reported LD50 in all the cases; however, residue levels of OA in larvae during the treatment application were very close to the reported LD50. Graphical abstract

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Section: Resultsmentioning

confidence: 99%

Ion chromatography coupled to Q-Orbitrap for the analysis of formic and oxalic acid in beehive matrices: a field study

et al. 2022

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“…Tandem MS is particularly suitable for the analysis of samples with complex component systems and serious interference. It plays a vital role in biological and chemical analysis (Petrie et al, 2019;Rajski et al, 2019;Heiles, 2021).…”

Section: Tandem Mass Analyzersmentioning

confidence: 99%

Towards Higher Sensitivity of Mass Spectrometry: A Perspective From the Mass Analyzers

Li¹,

Chu²,

Tan³

et al. 2021

Front. Chem.

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Mass spectrometry (MS) is one of the most widely used analytical techniques in many fields. Recent developments in chemical and biological researches have drawn much attention to the measurement of substances with low abundances in samples. Continuous efforts have been made consequently to further improve the sensitivity of MS. Modifications on the mass analyzers of mass spectrometers offer a direct, universal and practical way to obtain higher sensitivity. This review provides a comprehensive overview of the latest developments in mass analyzers for the improvement of mass spectrometers’ sensitivity, including quadrupole, ion trap, time-of-flight (TOF) and Fourier transform ion cyclotron (FT-ICR), as well as different combinations of these mass analyzers. The advantages and limitations of different mass analyzers and their combinations are compared and discussed. This review provides guidance to the selection of suitable mass spectrometers in chemical and biological analytical applications. It is also beneficial to the development of novel mass spectrometers.

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“…These OPs phosphorylate the hydroxyl of serine in cholinesterase (ChE), subsequently depressing the activity of ChE. , Thus, the concentration of acetylcholine (ACh) increases, posing a significant threat to human health. , In view of this, it is highly imperative to find an effective approach for determining OPs and investigating their distribution and degradation in agricultural crops. Chromatography, mass spectroscopy, and their tandem techniques have been widely applied in exploring the residues of OPs in product, water, and soil, but are limited to lengthy time, large and sophisticated equipment, skilled personnel, and relatively low sensitivity. , There is a need to develop a simple and sensitive method for OP sensing.…”

Section: Introductionmentioning

confidence: 99%

Inorganic Recognizer-Assisted Homogeneous Electrochemiluminescence Determination of Organophosphorus Pesticides via Target-Controlled Emitter Release

Yang

et al. 2021

J. Agric. Food Chem.

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Given the relevance of organophosphorus pesticides (OPs) with food safety, it is highly urgent to develop sensitive and reliable sensors for OPs. However, most of the OP sensors are developed based on colorimetric and fluorescent techniques, which are limited to severe interference of color and fluorescence from pigments and organic acids in agricultural crops. Herein, we develop an inorganic recognizer-based homogeneous electrochemiluminescence (ECL) sensor for the highly sensitive and credible determination of OPs based on manganese dioxide and tris(2,2′-bipyridine)ruthenium [Ru(bpy)3]2+. Through electrostatic interaction, manganese dioxide nanoflakes-[Ru(bpy)3]2+ nanocomposites (MnNFs-Ru) are formed and exhibit a weak ECL signal due to the confinement of [Ru(bpy)3]2+ in MnNFs-Ru. Interestingly, MnNFs-Ru are capable of recognizing thiols due to the analyte-initiated reduction of MnNFs into Mn2+ and release of [Ru(bpy)3]2+ from MnNFs-Ru into solution. Further, MnNFs-Ru are employed for the homogeneous ECL determination of OPs, where acetylcholinesterase (AChE) catalyzes the hydrolysis of acetylthiocholine (ATCh) into thiocholine, which in turn decomposes MnNFs of MnNFs-Ru into Mn2+, and OPs inhibit AChE activity. This study widens the application of inorganic recognizers from colorimetry/fluorescence to homogeneous ECL and effectively avoids the interference of color and fluorescence, opening up a new path to the development of high-performance OP sensors and supplying a promising tool for guaranteed OP-related food safety.

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LC-ESI-QOrbitrap™ MS/MS within pesticide residue analysis in fruits and vegetables

Cited by 38 publications

References 60 publications

Ion chromatography coupled to Q-Orbitrap for the analysis of formic and oxalic acid in beehive matrices: a field study

Ion chromatography coupled to Q-Orbitrap for the analysis of formic and oxalic acid in beehive matrices: a field study

Towards Higher Sensitivity of Mass Spectrometry: A Perspective From the Mass Analyzers

Inorganic Recognizer-Assisted Homogeneous Electrochemiluminescence Determination of Organophosphorus Pesticides via Target-Controlled Emitter Release

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