LC-ESI/MS-phytochemical profiling with antioxidant and antiacetylcholinesterase activities of Algerian <i>Senecio angulatus</i> L.f. extracts

Bousetla, A.; Keskinkaya, Hatice Banu; Bensouici, Chawki; Lefahal, Mostefa; Atalar, Mehmet Nuri; Akkal, Salah

doi:10.1080/14786419.2021.1947274

Cited by 8 publications

(7 citation statements)

References 25 publications

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“…This is the first contribution of the antioxidant activity of S. hoggariensis, therefore, it is important to compare data obtained with other plants under the same genus. Significant antioxidant activities were recorded in ethyl acetate fractions for S. inaequidens, S. vulgaris, (inhibition of DPPH equal to 61.60% and 44.57% of inhibition, respectively, at concentration of 0.31 mg/mL (Conforti et al 2006a), S. gibbosus (IC 50 of 0.01 mg/mL on DPPH) (Conforti et al 2006b) and in S. angulatus (IC 50 of 21.85 µg/mL on DPPH) (Bousetla et al 2021). These findings showed higher inhibition than that obtained in the present study.…”

Section: Discussionmentioning

confidence: 99%

Assessment of in vitro activities and chemical profiling of Senecio hoggariensis growing in Algerian Sahara

et al. 2022

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Abstract. Arab Y, Sahin B, Ceylan O, Zellagui A, Olmez OT, Kucukaydin S, Tamfu AN, Ozturk M, Gherraf N. 2022. Assessment of in vitro activities and chemical profiling of Senecio hoggariensis growing in Algerian Sahara. Biodiversitas 23: 3498-3506. The in vitro antioxidant, anticholinesterase, tyrosinase inhibitory, antibiofilm, and anti-quorum sensing activities of the ethyl acetate extract of Senecio hoggariensis,growing in Algerian Sahara, were studied along with its chemical constituents using HPLC-DAD. The chromatographic analysisunveiled seven phenolic compounds, including p-coumaric acid as a major component. Additionally, the extract showed moderate DPPH radical scavenging activity, compared to known standards. At 200 ?g/mL, the extract disclosed equitable acetylcholinesterase (AChE), butyryl-cholinesterase (BChE) and tyrosinase inhibition rates with respective values of 37.01±1.48%, 18.87±4.18% and 45.99±1.81%. Likewise, the extract exhibited a good antibiofilm activity against Candida albicans ATCC 10239 biofilm production with an inhibition ratio of 59.56±0.40%, at 50µg/mL. The anti-quorum sensing by QS-regulated violacein pigment production inhibition test was determined using Chromobacterium violaceum CV026 and CV12472. The swarming motility inhibition assay was determined using Pseudomonas aeruginosa PA01. It is evident from the findings that Senecio hoggariensis could be considered potential antioxidant, anti-QS, and antibiofilm compounds. However, the origin of anti-biofilm and anti-quorum sensing activities of the ethyl acetate extract could be revealed by further studies on the mechanism of action of active compounds that can be isolated via activity-guided fractionation.

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Section: Discussionmentioning

confidence: 99%

Assessment of in vitro activities and chemical profiling of Senecio hoggariensis growing in Algerian Sahara

et al. 2022

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“…The identified phenolic compounds as chlorogenic acid, caffeic acid, p-coumaric acid, rutin, quercetin etc. are typical for the Senecio taxa [9,11,13].…”

Section: 23flavonoidsmentioning

confidence: 99%

“…Senecio species are reported to accumulate sesquiterpenoids (eremophilanes, furanoeremophilanes, cacalols, eudesmanes, oplopanes, germacranes, etc.) and pyrrolizidine alkaloids (PAs) [1,8,9], phenolic compounds [10][11][12][13][14][15], and various other secondary metabolites [4,9,16]. Senecio species have been described to possess analgesic [17] and hypoglycemic [18] activity, related to the typical for the genus sesquiterpene lactones, and insecticidal properties [19] related to the presence of PAs.…”

Section: Introductionmentioning

confidence: 99%

“…Senecio species have been described to possess analgesic [17] and hypoglycemic [18] activity, related to the typical for the genus sesquiterpene lactones, and insecticidal properties [19] related to the presence of PAs. Additionally, the taxa are reported to express strong antioxidant, cytotoxic and antimicrobial activity due to the presence of phenolics [11][12][13]15].…”

Section: Introductionmentioning

confidence: 99%

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Chemophenetic Approach to Selected Senecioneae Species, Combining Morphometric and UHPLC-HRMS Analyses

Voynikov¹,

Balabanova²,

Gevrenova³

et al. 2022

Preprint

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Herein, a chemophenetic significance, based on phenolic metabolite profiling of three Senecio (S. hercynicus, S. ovatus and S. rupestris) and two Jacobaea species (J. pancicii and J. maritima) coupled to morphometric data, is presented. A set of twelve morphometric characters were recorded from each plant species and used as predictor variables in a Linear Discriminant Analysis (LDA) model. From a total 75 observations (15 from each of the five species), the model correctly assumed their species' membership, except 2 observations. Among the studied species, S. hercynicus and S. ovatus presented the greatest morphological similarity. A phytochemical profiling of phenolic specialized metabolites by UHPLC-Orbitrap-HRMS revealed 46 hydroxybenzoic, hydroxycinnamic, acylquinic acids and their derivatives, 1 coumarin, and 21 flavonoids. Hierarchical and PCA clustering applied to the phytochemical data corroborated the similarity of S. hercynicus and S. ovatus, observed in the morphometric analysis. This study contributes to the phylogenetic relationships between the tribe Senecioneae taxa and highlights the chemophenetic similarity/dissmilarity of the studied species belonging to Senecio and Jacobaea genera.

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“…Senecio species are reported to accumulate sesquiterpenoids (eremophilanes, furanoeremophilanes, cacalols, eudesmanes, oplopanes, germacranes, etc. ), pyrrolizidine alkaloids (PAs) [ 1 , 8 , 9 ], phenolic compounds [ 10 , 11 , 12 , 13 , 14 , 15 ], and various other secondary metabolites [ 4 , 9 , 16 ]. Senecio species have been described to possess analgesic [ 17 ] and hypoglycemic [ 18 ] activity, related to the typical for the genus sesquiterpene lactones, and insecticidal properties [ 19 ] related to the presence of PAs.…”

Section: Introductionmentioning

confidence: 99%

Chemophenetic Approach to Selected Senecioneae Species, Combining Morphometric and UHPLC-HRMS Analyses

Voynikov

Balabanova

Gevrenova

et al. 2023

Plants

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Herein, a chemophenetic significance, based on the phenolic metabolite profiling of three Senecio (S. hercynicus, S. ovatus, and S. rupestris) and two Jacobaea species (J. pancicii and J. maritima), coupled to morphometric data, is presented. A set of twelve morphometric characters were recorded from each plant species and used as predictor variables in a linear discriminant analysis (LDA) model. From a total 75 observations (15 from each of the five species), the model correctly assumed their species’ membership, except for 2 observations. Among the studied species, S. hercynicus and S. ovatus presented the greatest morphological similarity. A phytochemical profiling of phenolic specialized metabolites by UHPLC-Orbitrap-MS revealed 46 hydroxybenzoic, hydroxycinnamic, and acylquinic acids and their derivatives, 1 coumarin and 21 flavonoids. Hierarchical and PCA clustering applied to the phytochemical data corroborated the similarity of S. hercynicus and S. ovatus, observed in the morphometric analysis. This study contributes to the phylogenetic relationships between the tribe Senecioneae taxa and highlights the chemophenetic similarity/dissimilarity of the studied species belonging to Senecio and Jacobaea genera.

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LC-ESI/MS-phytochemical profiling with antioxidant and antiacetylcholinesterase activities of Algerian Senecio angulatus L.f. extracts

Cited by 8 publications

References 25 publications

Assessment of in vitro activities and chemical profiling of Senecio hoggariensis growing in Algerian Sahara

Assessment of in vitro activities and chemical profiling of Senecio hoggariensis growing in Algerian Sahara

Chemophenetic Approach to Selected Senecioneae Species, Combining Morphometric and UHPLC-HRMS Analyses

Chemophenetic Approach to Selected Senecioneae Species, Combining Morphometric and UHPLC-HRMS Analyses

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