LC-ESI/MS/MS analysis of neonicotinoids in urine of very low birth weight infants at birth

Ichikawa, Go; Kuribayashi, Ryota; Ikenaka, Yoshinori; Ichise, Takahiro; Nakayama, Shouta M.M.; Ishizuka, Mayumi; Taira, Kumiko; Fujioka, Kazutoshi; Sairenchi, Toshimi; Kobashi, Gén; Bonmatin, Jean‐Marc; Yoshihara, Shigemi

doi:10.1371/journal.pone.0219208

Cited by 73 publications

(50 citation statements)

References 47 publications

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“…To date, most neonicotinoid uses are (or are planned to be) suspended in Europe, with the exception of acetamiprid. Here, it is interesting to note that acetamiprid appeared one of the less toxic neonicotinoids for pollinators, but it is one of the most worrying neonicotinoids for human health (Ichikawa et al 2019).…”

Section: Regulations and Conclusionmentioning

confidence: 99%

“…Hallmann et al 2017;Krupke and Tooker 2020;Pelosi et al 2020;Ewere et al 2021) but affects also vertebrates, directly or indirectly (Paquet-Walsh et al 2019;Eng et al 2019). In addition, there is also growing pieces of evidence that mammals (including humans) can be directly affected by these insecticides (Taira 2014;Cimino et al 2016;Caron-Beaudoin et al 2017;Wang et al 2017;Berheim et al 2019;Ospina et al 2019;Ichikawa et al 2019;Wang et al 2020;Thompson et al 2020;Oya et al 2020;Bonmatin et al 2020); this in sharp opposition to what was expected at the time of their registration.…”

Section: Regulations and Conclusionmentioning

confidence: 99%

See 1 more Smart Citation

An update of the Worldwide Integrated Assessment (WIA) on systemic insecticides

Bonmatin

Giorio

Sánchez‐Bayo

et al. 2021

Environ Sci Pollut Res

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Section: Regulations and Conclusionmentioning

confidence: 99%

Section: Regulations and Conclusionmentioning

confidence: 99%

An update of the Worldwide Integrated Assessment (WIA) on systemic insecticides

Bonmatin

Giorio

Sánchez‐Bayo

et al. 2021

Environ Sci Pollut Res

Self Cite

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“…While daily intakes are below the current chronic reference doses, concern is raised over the health risk of neonicotinoids to children via dietary exposure due to their increased use and ubiquitous presence in fruits and vegetables. -Ichikawa et al (2019) report the first evidence worldwide of neonicotinoid exposure in new born babies in the early phase after birth, suggesting a need to examine potential neurodevelopmental toxicity of neonicotinoids and metabolites in human foetuses. -Becker et al (2020) found that selection pressure from contamination by imidacloprid (and diazinon) caused insensitive snails to dominate over their less tolerant competitors, increasing a pathway for transmission of Schistosomiasis.…”

Section: Human Exposurementioning

confidence: 99%

Social, Psychological and Health Impact of Coronavirus Disease (COVID-19) on the Elderly: South African and Italian Perspectives

2021

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Agriculture is critically important for African societies and economies but ensuring food security for Africa’s growing population is a major challenge. One particular concern are pesticides called ‘neonicotinoids’, which render all parts of a plant toxic to all insects and contaminate the soil and water bodies. By exposing all organisms to the toxins, neonicotinoids also harm beneficial insects that provide many important ‘ecosystem services’, such as pollination, soil development, and natural pest control, which are an integral part of sustainable agriculture. Neonicotinoids have contributed to the loss of ecosystem services from pollinators and other insects in Europe and elsewhere, and several of them have been banned in the (European Union) EU and other countries due to their harmful effect on beneficial insects. Africa, with its rich biodiversity and heavy reliance on agricultural production, is one of the fastest-growing pesticide markets in the world, so protecting it from the harmful effects of neonicotinoids is vital to ensuring a sustainable agriculture that provides food security. The Academy of Science of South Africa (ASSAf), in collaboration with the German National Academy of Sciences Leopoldina and the Network of African Science Academies (NASAC) has recently completed a project exploring the use and effects of neonicotinoids in African agriculture. This project brought together experts from 17 African countries, reviewed the relevant African scientific literature, and analysed the state of knowledge on neonicotinoids and their impact on ecosystem services for agriculture and on biodiversity in Africa. The resultant report ‘Neonicotinoid insecticides: use and effects in African agriculture. A review and recommendations to policy makers’ (NASAC, 2019) has collated an unprecedented amount of information, identified gaps in scientific knowledge and research relating to neonicotinoids in Africa, and developed key recommendations from science to policy-makers to ensure the sustainability of African agriculture and thus food security. One year after the launch of the NASAC report, the purpose of this virtual event was to introduce the report, including an update on recent global scientific and African policy developments regarding neonicotinoids, and to discuss its implications with a wide range of stakeholders, with the aim of stimulating policy and research action on this important issue. The target audience and participants included South African and Southern African Development Community (SADC) policymakers, regulatory agencies, government departments, agricultural associations, extension-service providers, research institutes, international development agencies, representatives of embassies, and other interested stakeholders.

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“…Both overall reliance on pesticides relative to other pest-management tools, and the number and diversity of residues in diets have risen steadily for decades. The world's most widely used herbicide (glyphosate) and heavily applied family of insecticides (neonicotinoids) are routinely detected in human urine [7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

The dietary risk index system: a tool to track pesticide dietary risks

Benbrook¹,

Davis

2020

Environ Health

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Background For years the United States Department of Agriculture’s Pesticide Data Program and the United Kingdom’s Food Standards Agency have published annual or quarterly data on pesticide residues in foods. Both programs report residues in conventionally grown, organic, and imported foods. The US program has tested about 288,000 food samples since 1992, primarily fruits and vegetables consumed by children. Since 1999 the UK has tested about 72,000 samples of a wider range of foods. These data are vital inputs in tracking trends in pesticide dietary risks. Methods The Dietary Risk Index (DRI) system facilitates detailed analyses of US and UK pesticide residue data, trends, and chronic risk distributions. The DRI value for a pesticide is the dietary intake of that pesticide from a single serving of food divided by the pesticide’s acceptable daily intake as set by the US Environmental Protection Agency. It can be calculated based on average annual residue concentrations, and on residue levels in individual samples of food. DRI values can be aggregated over multiple pesticides in single foods, and over individual pesticides in multiple foods. Results The DRI system provides insights into the levels, trends, and distribution of pesticide dietary risk across most widely consumed foods. By drawing on both US Pesticide Data Program and UK-Food Standards Agency residue data, the DRI is capable of assessing pesticide risks in a significant portion of the global food supply. Substantial reductions in pesticide dietary risks occurred in the early 2000s, primarily from replacement of organophosphate insecticides with seemingly lower-risk neonicotinoids. However, there remain several areas of concern and opportunities to reduce risks. Both herbicide and fungicide dietary risks are rising. Organically grown produce poses risks far lower than corresponding, conventionally grown produce. Risk differences are inconsistent between domestic and imported foods. Conclusions The surest ways to markedly reduce pesticide dietary risks are to shift relatively high-risk fruits and vegetables to organic production. For other foods, reducing reliance on pesticides overall, and especially high-risk pesticides, will incrementally lower risks. The DRI system can help focus such efforts and track progress in reducing pesticide dietary risk.

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LC-ESI/MS/MS analysis of neonicotinoids in urine of very low birth weight infants at birth

Cited by 73 publications

References 47 publications

An update of the Worldwide Integrated Assessment (WIA) on systemic insecticides

An update of the Worldwide Integrated Assessment (WIA) on systemic insecticides

Social, Psychological and Health Impact of Coronavirus Disease (COVID-19) on the Elderly: South African and Italian Perspectives

The dietary risk index system: a tool to track pesticide dietary risks

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