LC determination of rofecoxib in bulk and pharmaceutical formulations

Application of HPLC and HPTLC for the simultaneous determination of tizanidine and rofecoxib in pharmaceutical dosage form

“…Several LC-MS methods for determination of rofecoxib in human plasma have been reported [18][19][20]. Simple reverse phase HPLC method for quantitative estimation of rofecoxib in pharmaceutical formulation [21] and from human plasma [22][23][24] has been reported. Mao et al [25] has reported stability indicating HPLC method for rofecoxib.…”

An overview of the recent developments in analytical methodologies for determination of COX-2 inhibitors in bulk drugs, pharmaceuticals and biological matrices

“…Further they have extended their work to characterize the process related impurities 4-[4(methyl sulphony)phenyl]-3-phenyl, 5-hydroxy furan-2-one (1) and 4-[4(methyl sulphony)phenyl]-3-phenyl, 2,5-furandione using preparative HPLC, NMR and MS. Impurity profiles were generated. The data was validated and the reported percentage recoveries ranged from 98.2 to 102.6 [139,140]. The stability of RXB under different alkaline, photolytic stress conditions was studied.…”

Development and validation of an HPLC method for determination of rofecoxib in bovine serum albumin microspheres

“…Therefore, this study was designed to develop a simple, fast, and validated HPLC method for determination of rofecoxib in BSA microspheres. Since there are many types of HPLC methods depending on detector and column types, it is a challenge for the researchers to choose a suitable method for their drug delivery systems [15,16]. In this study, the optimum chromatographic and analytical parameters were investigated and the method validation studies were performed according to FDA guideline in line with the bioanalytical method validation procedure.…”