LC determination of morphine and morphine glucuronides in human plasma by coulometric and UV detection

Ary, K; Róna, Kálmán

doi:10.1016/s0731-7085(01)00393-4

Cited by 39 publications

(18 citation statements)

References 15 publications

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“…HPLC with UV detection is a common analytical method for these drugs in biological samples. However, many reports describe the need for multiple extractions and complex chromatographic systems to ensure reproducibility and resolution [19][20][21][22][23][24][25]. Recently, a method employing HPLC combined with electro spray ionization-tandem mass spectrometry (HPLC-ESI-MS-MS) for low level quantitation of MOR, M3G and M6G has been described [26].…”

Section: Discussionmentioning

confidence: 99%

Relationship between plasma concentrations of morphine and its metabolites and pain in cancer patients

et al. 2010

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Section: Discussionmentioning

confidence: 99%

Relationship between plasma concentrations of morphine and its metabolites and pain in cancer patients

et al. 2010

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“…Using liquid chromatography dual electrode detection (LC-DED) in conjunction with UV detection Ary and Róna [56] have reported on the determination of morphine (VIII) (7,8-didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol) and its glucuronides; morphine-3-glucuronide, morphine-6-glucuronide. Morphine (VIII) and its glucuronides were extracted from human plasma using BondElut C18 (1 mL) SPE cartridges.…”

Section: Alkaloidsmentioning

confidence: 99%

Review: The Application of Liquid Chromatography Electrochemical Detection for the Determination of Drugs of Abuse

Honeychurch

2016

Separations

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This review (4 tables, 88 references) describes current developments in the design and application of liquid chromatography electrochemical detection (LC ED) based approaches for the determination of drugs of abuse. Specific emphasis is placed on operating details and performance characteristics for selected applications. LC ED has been shown to be highly sensitive and specific as well being a more economic option. A wide range of abused substances have been determined using this approach, including: cannabinoids, ethanol, opiates, morphine, mushroom toxins, benzodiazepines and several legal highs. Reverse-phase liquid chromatography with either amperometric or coulometric determination has been the most commonly reported applications. However, coulometric arrays have been also reported. Detection limits in the ng/mL region have been reported for most target analytes.

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“…Many analytical methods have been employed for MOR monitoring. Various chromatographic methods such as liquid chromatography coupled with UV detection [4], gas chromatographymass spectrometry [5], thin layer chromatography [6], high [7] and ultra [8] performance liquid chromatography. Resonance light scattering [20] and time-resolved chemiluminescence [9] methods have been also used.…”

Section: Introductionmentioning

confidence: 99%

Competitive voltammetric morphine immunosensor using a gold nanoparticle decorated graphene electrode

Eissa

Zourob

2017

Microchim Acta

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The authors describe a voltammetric immunosensor for morphine (MOR) that is based on a graphene screen printed electrode (GSPE) modified with gold nanoparticles (AuNP) which were electrodeposited on its surface. The gold nanoparticles were characterized by scanning electron microscopy, Xray photoelectron spectroscopy and cyclic voltammetry. Cysteamine was then self-assembled on the gold-modified electrodes via thiol interaction in order to introduce terminal amino groups to the electrode surface. The electrodes were then used to fabricate the immunosensor by covalent immobilization of antibodies against MOR. The sensor works on the basis of a competition between MOR and the morphine-bovine serum albumin (MOR-BSA) conjugate for the immobilized antibodies on the sensor surface and the resulting change in the square wave voltammetry reduction current using the hexacyanoferrate system as an electrochemical probe. The competitive immunoassay enables sensitive and selective detection of MOR in the 0.1 to 100 ng·mL −1 MOR concentration range, with a 90 pg·mL −1 detection limit. The method was applied to the determination of MOR in spiked saliva samples and showed high recoveries. We believe that this immunosensor offers a simple, rapid, sensitive and accurate MOR test.

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LC determination of morphine and morphine glucuronides in human plasma by coulometric and UV detection

Cited by 39 publications

References 15 publications

Relationship between plasma concentrations of morphine and its metabolites and pain in cancer patients

Relationship between plasma concentrations of morphine and its metabolites and pain in cancer patients

Review: The Application of Liquid Chromatography Electrochemical Detection for the Determination of Drugs of Abuse

Competitive voltammetric morphine immunosensor using a gold nanoparticle decorated graphene electrode

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