LbL Assemblies Using van der Waals or Affinity Interactions and Their Applications

Surface Engineered Protein Nanoparticles With Hyaluronic Acid Based Multilayers For Targeted Delivery Of Anticancer Agents

“…Such a strategy can facilitate targeted or enhanced cellular uptake, stimuli-responsive release, and protection from opsonization, as well as early degradation during carrier transport. − The LbL technique involves the deposition of oppositely charged polyelectrolytes or other charged entities to form multilayer architectures with nanometer precision . The driving forces involved in multilayer assembly are primarily electrostatic in nature but can also involve hydrogen bonding, hydrophobic interactions, van der Waals forces, covalent bonding, or click chemistry modifications. , The LbL assembly has been utilized to manipulate the surface characteristics of drug-loaded polymeric nanoparticles, liposomes, mesoporous silica nanoparticles (MSN), quantum dots, and carbon nanotubes . In most of these systems, LbL modification enables stimuli-responsive gating or controlling the release of pre-encapsulated molecules by minimizing the initial burst-release, maintaining a sustained release, or extending the duration of release.…”