LB1.1 Insights into the evolution of syphilis spirochetes within at-risk populations: sequence variation of outer membrane protein β-barrel domains in clinical samples
Abstract:IntroductionOuter membrane proteins (OMPs) play critical roles in disease pathogenesis and are vaccinogens. Topologic characterisation of surface-exposed β-barrels of Treponema pallidum (Tp) Nichols rare OMPs enabled a novel strategy to assess sequence diversity and evolution of Tp in geographically diverse locations.MethodsThrough early 2017, sequences encoding TprC (TP0117), TprD (TP0131), and BamA (TP0326) β-barrels were amplified from secondary syphilis patients from Cali (n=16) and swabs from patients in … Show more
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