Layered terbium hydroxides for simultaneous drug delivery and imaging

Abstract

Layered rare-earth hydroxides have begun to gather increasing attention as potential theranostic platforms owing to their extensive intercalation chemistry combined with magnetic and fluorescent properties. In this work, the potential...

Layered rare-earth hydroxides as multi-modal medical imaging probes: particle size optimisation and compositional exploration

“…For initial synthesis optimisation experiments, the temperature was set to 100 °C and 200 °C (50 °C above and below the previously reported method), 1 with incubation times of 10 and 24 h (compared to 15 h originally). The fill volumes chosen were approximately half the capacity of the reactor (10 ml) and full capacity (18 ml), whilst leaving some room for air in order to prevent vessel leakage.…”

“…These guest moieties may be selected to exert a therapeutic effect, as well as to modify the overall contrast properties of the parent LRH material. Moreover, LRH materials have previously been shown to be stable at physiological pH 1 and well-tolerated in cytotoxicity studies 7,8 (though in vivo applications of LRHs are thus far extremely limited in scope, and long-term toxicity is not yet explored). As such, LRHs are attracting increasing interest in the field of theranostics.…”

“…To date, many LRH materials have been successfully synthesised, with a wide range of parent compositions and guest species such as amino acids and drug anions. 9–12 LRH theranostic platforms based on Gd and Tb have been reported previously by our group; 1,13 despite favourable overall performance, the reported hydrothermal synthesis protocols produced inhomogeneous mixtures of nano- and microparticles, which without further optimisation are not suitable for translation towards the clinic. The inhomogeneity of previously synthesised LRH particles is problematic, as both size and geometry of particulate formulations affect their performance in vivo .…”

Facile Synthesis of Organic–Inorganic Hybrid Layered Rare‐Earth Hydroxide Nanocone for Multifunctional Drug Delivery System with Fluorescence Probe and Simultaneous Magnetic Resonance Imaging

“…Compared with the drug delivery research reported in the previous literature, this system has more unique nanostructures, richer luminescent, and magnetic functions. [12,13,52] Moreover, since other similar LDH has been proved to deliver a variety of drugs, proteins, etc. and produce corresponding performance changes, [52][53][54] the preparation of YTG-ASA integrated with multiple functions in one drug delivery system is expected to be gradually extended to other drugs in the future, which has wide prospects in biomedical fields.…”

“…[ 12,13,52 ] Moreover, since other similar LDH has been proved to deliver a variety of drugs, proteins, etc. and produce corresponding performance changes, [ 52–54 ] the preparation of YTG‐ASA integrated with multiple functions in one drug delivery system is expected to be gradually extended to other drugs in the future, which has wide prospects in biomedical fields.…”