Layered self-assemblies for controlled drug delivery: A translational overview

Sarode, Apoorva; Annapragada, Akshaya V.; Guo, Junling; Mitragotri, Samir

doi:10.1016/j.biomaterials.2020.119929

Cited by 52 publications

(39 citation statements)

References 156 publications

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“…Some studies have shown that the drug toxicity can be effectively alleviated by local administration of slow-release materials. [25][26][27][28] We explored the effects of the sustained-release materials loaded with antitumor drugs in this study. The results indicated that the sustained-release materials could effectively inhibit tumor growth and partly reduce the side effects of systemic chemotherapy, such as liver damage and myelosuppression.…”

Section: Discussionmentioning

confidence: 99%

The Delivery Materials with Chemotherapy Drugs for Treatment of the Positive Margin in Solid Tumors

Zhu

Liu

Feng

et al. 2020

Tissue Engineering Part A

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The positive surgical margins in solid tumors has been a disturbing issue for clinicians. Chemotherapy is an important method to deal with the positive margin. However, systemic chemotherapy is required for long-term administration and has great side effects on health, which cause great pain to the patients. Local administration of slow-release materials provides an opportunity to improve the situation. In this study, we utilized electrospinning technology to create the drug sustained-release materials with nanofibrous structure, which were made from polylactic acid and a certain proportion of chemotherapy drugs (gemcitabine and cisplatin). In vitro release behavior of the drug sustained-release materials were explored by the high-performance liquid chromatography. The antitumor efficacy of the drug sustained-release materials was preliminarily verified in prostate cancer and breast cancer in vitro. Through animal models of breast cancer, the drug sustained-release materials in the treatment of the positive margin has been well documented in vivo, and we also found that the drug sustained-release materials could definitely reduce the liver damage and myelosuppression compared with systemic chemotherapy. In summary, the experimental results showed that the local administration of the drug sustained-release materials could effectively inhibit the growth of the positive incision margins and definitely reduce the partial side effects associated with systemic chemotherapy.

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Section: Discussionmentioning

confidence: 99%

The Delivery Materials with Chemotherapy Drugs for Treatment of the Positive Margin in Solid Tumors

Zhu

Liu

Feng

et al. 2020

Tissue Engineering Part A

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“…With high risk developmental challenges for new drugs, companies have resisted risk in delivery strategies posed by new entities and new degradable polymers. For this reason, well established polymer systems, such as the polyesters noted above continue to dominate the delivery landscape despite limitations of bulk erosion and burst release challenges that are mitigated in many cases with elegant formulation or multilayer fabrication strategies 134,135 .…”

Section: Bench To Market Considerationsmentioning

confidence: 99%

Degradable polymeric vehicles for postoperative pain management

Brigham

Becker

2021

Nat Commun

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Effective control of pain management has the potential to significantly decrease the need for prescription opioids following a surgical procedure. While extended release products for pain management are available commercially, the implementation of a device that safely and reliably provides extended analgesia and is sufficiently flexible to facilitate a diverse array of release profiles would serve to advance patient comfort, quality of care and compliance following surgical procedures. Herein, we review current polymeric systems that could be utilized in new, controlled post-operative pain management devices and highlight where opportunities for improvement exist.

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“…Architecture diversity is a must for achieving the desired properties such as degradation, optimal, mechanical, thermal and biological properties for any specific biomedical application (Wang, Lu, et al, 2019). Several linear , star-shaped , hyperbranched and cross-linked In the sense of well-defined architecture, self-assembly of polymers is a newly emerging field having great potential in biomedical sciences (Sarode et al, 2020;Tian & Zhang, 2019). Self-assembled copolymers of diblock oligomers of tetraaniline and poly(L-lactide)…”

Section: Conduc Ting P Olymer Smentioning

confidence: 99%

“…In the sense of well‐defined architecture, self‐assembly of polymers is a newly emerging field having great potential in biomedical sciences (Sarode et al, 2020; Tian & Zhang, 2019). Self‐assembled copolymers of diblock oligomers of tetraaniline and poly(L‐lactide) were synthesized via using tetraaniline as an initiator for ring‐opening polymerization of L‐lactide and studied their performance on self‐assembly in chloroform solvent (Wang et al, 2006).…”

Section: New Biodegradable Conducting Polymersmentioning

confidence: 99%

Biodegradable conducting polymeric materials for biomedical applications: a review

2020

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Biomaterials are natural or synthetic materials that are biodegradable and interact cordially with biological systems (Qu et al., 2019). These can be well-defined as a material envisioned to interface with biological systems for evaluation, treatment and replacement of organs, tissues or function of the body (Basu & Ghosh, 2017; Reis et al., 2016). They play a key role in the human health system which is attained from nature or the environment (Mir et al., 2018). Generally, biopolymers are the main class of biomaterials as biopolymers are biocompatible, biodegradable and human body-friendly (Rebelo et al., 2017). These biopolymers are further classified as biodegradable and non-biodegradable according to their nature (Andreeßen & Steinbüchel, 2019; Kabir et al., 2020). Due to their outstanding biocompatibility, biodegradable polymers are known as the best candidate for biomedical applications such as drug delivery systems, vascular grafts, surgical sutures, artificial skin, bone fixation devices, gene delivery systems, tissue engineering and diagnostic applications. Biomedical engineering is an attractive branch which deals with engineering and biology together to put on engineering materials and rudiments in the field of healthcare and medicine. Tissue engineering is also a part of it that fulfils the purposes of recovering or exchange failing or broken body tissue by merging cells, scaffolds and bioactive molecules. Scaffolds should combine various functions such as biodegradability, biocompatibility, ideal mechanical strength, adequate porosity for small molecule transportation, controllability, implantation and sterilization. Hence, natural polymers such as gelatin and chitosan are the perfect match for scaffold fabrication and synthetic aliphatic polyesters too. However, these revealed poor hydrophilicity which limits the cell attachment on surfaces and lack of sites for covalent bonding. While having their biodegradable nature, biopolymers or conventional polymers are insulators in nature so that limits the use in some biomedical applications where conducting properties of biomaterials is indispensable (George et al., 2020). In many applications of implants in the body, such as in bone fixing materials, dental materials and bone substitution materials, there is a need for such type of material showing long-term stable performance. In other applications such as controlled drug delivery, regenerative medicine, tissue engineering

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Layered self-assemblies for controlled drug delivery: A translational overview

Cited by 52 publications

References 156 publications

The Delivery Materials with Chemotherapy Drugs for Treatment of the Positive Margin in Solid Tumors

The Delivery Materials with Chemotherapy Drugs for Treatment of the Positive Margin in Solid Tumors

Degradable polymeric vehicles for postoperative pain management

Biodegradable conducting polymeric materials for biomedical applications: a review

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