Layered mechanical and electrical properties of porcine articular cartilage

Sun, Yuqin; Zhang, Kai; Dong, Hao; Wang, Yan; Yan, Yang; Yu, Juanjuan; Wu, Xiaogang; Zhang, Meizhen; Wang, Yanqin; Chen, Weiyi

doi:10.1007/s11517-022-02653-6

Cited by 4 publications

(3 citation statements)

References 31 publications

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“…[ 39c ] Extensive research has demonstrated a gradual decrease in resistivity (with the shallow layer exhibiting a superior conductive effect), an increase in elastic modulus, and a decrease in permeability from the deep layer to the shallow layer of cartilage. [ 44 ] Research indicates that obesity, exercise, and excessive weight‐bearing can induce mechanical alterations in cartilage tissue, leading to an uneven distribution of charge and the subsequent generation of electrical signals through negatively charged cartilage ECM. [ 45 ] Furthermore, the degeneration of cartilage tissue, which can be attributed to factors such as aging, trauma, or pathological changes, has been found to diminish endogenous electrical signaling.…”

Section: Electrical Properties Of Bone and Articular Cartilage Tissuementioning

confidence: 99%

Electroactive Biomaterials Regulate the Electrophysiological Microenvironment to Promote Bone and Cartilage Tissue Regeneration

Chen,

Yang,

Cai

et al. 2024

Adv Funct Materials

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The incidence of large bone and articular cartilage defects caused by traumatic injury is increasing worldwide; the tissue regeneration process for these injuries is lengthy due to limited self‐healing ability. Endogenous bioelectrical phenomenon has been well recognized to play an important role in bone and cartilage homeostasis and regeneration. Studies have reported that electrical stimulation (ES) can effectively regulate various biological processes and holds promise as an external intervention to enhance the synthesis of the extracellular matrix, thereby accelerating the process of bone and cartilage regeneration. Hence, electroactive biomaterials have been considered a biomimetic approach to ensure functional recovery by integrating various physiological signals, including electrical, biochemical, and mechanical signals. This review will discuss the role of endogenous bioelectricity in bone and cartilage tissue, as well as the effects of ES on cellular behaviors. Then, recent advances in electroactive materials and their applications in bone and cartilage tissue regeneration are systematically overviewed, with a focus on their advantages and disadvantages as tissue repair materials and performances in the modulation of cell fate. Finally, the significance of mimicking the electrophysiological microenvironment of target tissue is emphasized and future development challenges of electroactive biomaterials for bone and cartilage repair strategies are proposed.

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Section: Electrical Properties Of Bone and Articular Cartilage Tissuementioning

confidence: 99%

Electroactive Biomaterials Regulate the Electrophysiological Microenvironment to Promote Bone and Cartilage Tissue Regeneration

Chen,

Yang,

Cai

et al. 2024

Adv Funct Materials

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show abstract

“…It was shown that resistivity gradually increases from the superficial to the deep zone of cartilage, which means that the superficial zone of cartilage contains more mobile charged particles, than the deeper zones, and conducts electrical charge more efficiently. The elastic modulus also increases going from the superficial to the deep zone while the permeability of cartilage decreases [ 47 ]. There is not much data about the conductivity of articular cartilage ( Table 1 ).…”

Section: Electromechanics Of Articular Cartilagementioning

confidence: 99%

Electrical Stimulation in Cartilage Tissue Engineering

et al. 2023

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Electrical stimulation (ES) has been frequently used in different biomedical applications both in vitro and in vivo. Numerous studies have demonstrated positive effects of ES on cellular functions, including metabolism, proliferation, and differentiation. The application of ES to cartilage tissue for increasing extracellular matrix formation is of interest, as cartilage is not able to restore its lesions owing to its avascular nature and lack of cells. Various ES approaches have been used to stimulate chondrogenic differentiation in chondrocytes and stem cells; however, there is a huge gap in systematizing ES protocols used for chondrogenic differentiation of cells. This review focuses on the application of ES for chondrocyte and mesenchymal stem cell chondrogenesis for cartilage tissue regeneration. The effects of different types of ES on cellular functions and chondrogenic differentiation are reviewed, systematically providing ES protocols and their advantageous effects. Moreover, cartilage 3D modeling using cells in scaffolds/hydrogels under ES are observed, and recommendations on reporting about the use of ES in different studies are provided to ensure adequate consolidation of knowledge in the area of ES. This review brings novel insights into the further application of ES in in vitro studies, which are promising for further cartilage repair techniques.

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“…12 Both the middle and deep zone have good performance against compression, playing the role of maintaining body fluid and cushioning. 13 Therefore, it is of great scientific value to study the dynamic mechanical properties of each layer of articular cartilage and further refine the damage process of layered structure. The axial compressive strain of the surface layer and middle layer of cartilage in the relaxation period increases significantly under dynamic load conditions.…”

Section: Introductionmentioning

confidence: 99%

A novel assessment of dynamic mechanical properties in different articular cartilage layers

Zhang

Chen

et al. 2022

Journal of Thermoplastic Composite Materials

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Human articular cartilage, a nonlinear, viscoelastic solid-liquid biphasic tissue, has different mechanical properties and undertakes different functions in different layer. The compression deformation and fatigue damage mechanism of each layer of cartilage is also different when in injury. Compression properties of cartilage can predict cartilage integrity and the likelihood of osteoarthritis. Therefore, the confined and unconfined compression of cartilage is taken to systematically study the dynamic mechanical properties of each layer and reveal the relationship between the dynamic mechanical properties of each cartilage layer and the function of the corresponding cartilage layer. Under confined and unconfined compression conditions, the larger the cyclic loading rate, the greater the deformation rate of each layer. In addition, under the same cyclic loading rate, the superficial layer had the highest deformation rate, followed by the middle layer and the deep layer, which indicates that the deep layer mainly assumes the compression load. Furthermore, under the same loading displacement, the loading stress of cartilage and the deformation rate of each layer in confined compression were greater than those in unconfined compression. Simultaneously, with the increase in the number of loading cycles, the deformation rate in different layers increased first and then stabilized.

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Layered mechanical and electrical properties of porcine articular cartilage

Cited by 4 publications

References 31 publications

Electroactive Biomaterials Regulate the Electrophysiological Microenvironment to Promote Bone and Cartilage Tissue Regeneration

Electroactive Biomaterials Regulate the Electrophysiological Microenvironment to Promote Bone and Cartilage Tissue Regeneration

Electrical Stimulation in Cartilage Tissue Engineering

A novel assessment of dynamic mechanical properties in different articular cartilage layers

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