Layered inorganic nanocomposites: A promising carrier for 5-fluorouracil (5-FU)

Kevadiya, Bhavesh D.; Patel, Tapan; Jhala, Devendrasinh; Thumbar, Rahul P.; Brahmbhatt, Harshad; Pandya, Maharshi P.; Rajkumar, Shalini; Jena, Prasant Kumar; Joshi, Ghanshyam V.; Gadhia, Pankaj; Tripathi, C. B.; Bajaj, Hari C.

doi:10.1016/j.ejpb.2012.01.004

Cited by 96 publications

(59 citation statements)

References 28 publications

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“…54 Thus, the observed increase in d001 is in the lower end of the smallest dimension of the lactose molecule, which indicates that the lactose molecules lay flat in the Na-MMT interlayer space. This is in agreement with previously described results for intercalation of 5-fluorouracil, 9 oxytetracycline, 12, 13 and timolol maleate 7 in MMT.…”

Section: Intercalation Of Lactosesupporting

confidence: 93%

“…5 MMT has been used recently as an excipient in pharmaceutical applications, including transdermal formulations, tablets for oral administration, and as an extended release agent for tablets. [6][7][8][9][10] Furthermore, inclusion of photodegradable drug molecules within MMT may increase the photostability. 11 In this context, we further explore possible use of 3 MMT as a pharmaceutical excipient.…”

Section: Introductionmentioning

confidence: 99%

“…5 There is significant amount of published research on organic polymer-clay nanocomposites, but only few report on MMT combined with low-molecular-weight organic compounds including peptides and amino acids. [7][8][9][10][11][12][13][14][15][16][17][18][19] In these reports, the most important mechanism involved in intercalation into MMT is cationic exchange. 7-9, 12, 13, 19 Anionic and nonionic compounds have also been demonstrated to interact with MMT.…”

Section: Introductionmentioning

confidence: 99%

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Structure and Mobility of Lactose in Lactose/Sodium Montmorillonite Nanocomposites

et al. 2016

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This study aims at investigating the molecular level organization and molecular mobility in montmorillonite nanocomposites with the uncharged organic low-molecular-weight compound lactose commonly used in pharmaceutical drug delivery, food technology, and flavoring. Nanocomposites were prepared under slow and fast drying conditions, attained by drying at ambient conditions and by spray-drying, respectively. A detailed structural investigation was performed with modulated differential scanning calorimetry, powder X-ray diffraction, solidstate nuclear magnetic resonance, scanning electron microscopy, microcalorimetry, and molecular dynamic simulations. The lactose was intercalated in the sodium montmorillonite interlayer space regardless of the clay content, drying rate, or humidity exposure. Although, the spray-drying resulted in higher proportion of intercalated lactose compared with the drying under 2 ambient conditions, non-intercalated lactose was present at 20 wt% lactose content. This indicates limitations in maximum load capacity of nonionic organic substances into the montmorillonite interlayer space. Furthermore, a fraction of the intercalated lactose in the cospray-dried nanocomposites diffused out from the clay interlayer space upon humidity exposure.Also, the lactose in the nanocomposites demonstrated higher molecular mobility than that of neat amorphous lactose. This study provides a foundation for understanding functional properties of nanocomposites, such as loading capacity and physical stability.

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Section: Intercalation Of Lactosesupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Structure and Mobility of Lactose in Lactose/Sodium Montmorillonite Nanocomposites

et al. 2016

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“…Contemporaneously, researchers have been interested in the investigation of the intercalation reactions (IRs) that involves kaolinite layered phyllosilicates for the purpose of scientific and technological advancements in the areas of catalysis; water filtration; composites; nanotechnology; controlled released formulations [1,2] such as drug delivery systems (DDSs) and controlled release fertilizers (CRFs) [3][4][5][6][7][8][9][10]. Progressive application of kaolinite in the engineering designs has been practically feasible owing to the fact that kaolinite (which is an inexpensive chemical mineral) can be modified through ion exchange mechanisms by just intercalation of ionic species into the kaolinite interlayer spaces.…”

Section: Introductionmentioning

confidence: 99%

Dynamics of Kaolinite-Urea Nanocomposites via Coupled DMSO-Hydroxyaluminum Oligomeric Intermediates

Sempeho

Kim

Mubofu

et al. 2015

Indian Journal of Materials Science

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Kaolinite-urea nanocomposites were prepared via intercalation reactions in an attempt to investigate the dynamic nature of kaolinite morphology for advanced applications in controlled release systems (CRS). Characterization was done using SEM-EDX, XRF, ATR-FTIR, XRD, and DT/DTG; Andreasen pipette sedimentation technique was used to determine the grain size distribution of the raw kaolinite. The X-ray diffraction pattern revealed the existence of an FCC Bravais lattice where the intercalation ratios attained were 51.2%, 32.4%, 7.0%, and 38.4% for hydroxyaluminum oligomeric intercalated kaolinite, substituted urea intercalated kaolinite, calcined DMSO intercalated kaolinite, and hydroxyaluminum reintercalated kaolinite, respectively, along with their respective crystallite sizes of 33.51-31.73 nm, 41.92-39.69 nm, 22.31-21.13 nm, and 41.86-39.63 nm. The outcomes demonstrated that the employed intercalation routes require improvements as the intercalation reactions were in average only ≈32.3%. The observations unveiled that it is possible to manipulate kaolinite structure into various morphologies including dense-tightly packed overlapping euhedral pseudo hexagonal platelets, stacked vermiform morphologies, postulated forms, and unique patterns exhibiting self-assembled curled glomeruli-like morphologies. Such a diversity of kaolinite morphologies expedites its advanced applications in the controlled release systems (CRS) such as drug delivery systems and controlled release fertilizers (CRFs).

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“…38 TGA and differential scanning calorimetry curves were used to explain the new chemical bonding of these hybrids further. 39,40 BH showed a sharp weight loss (about 95 wt%) at 240°C-450°C, because of its total decomposition (Figure 7). Acid-Mt showed a slight weight loss (about 8 wt%) at 120°C, due to the evaporation of adsorbed water.…”

mentioning

confidence: 99%

A novel ion-exchange carrier based upon liposome-encapsulated montmorillonite for ophthalmic delivery of betaxolol hydrochloride

Huang¹,

Qi²,

Hou³

et al. 2017

IJN

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As a novel ion-exchange carrier with high surface area and excellent exchangeability, montmorillonite (Mt) was intercalated with betaxolol hydrochloride (BH) to form a nanocomposite and then encapsulated by liposomes (Mt-BH-LPs) for an ophthalmic drug-delivery system. The Mt-BH and Mt-BH-LPs were prepared by an acidification process and ethanol injection combined with ammonium sulfate gradient methods. The successful formation of Mt-BH and Mt-BH-LPs was verified by thermogravimetric analysis, X-ray diffraction, Fourier-transform infrared spectra, and transmission electron microscopy. Mt-BH-LPs possessed the favorable physical characteristics of encapsulation efficiency, drug loading, mean particle size, and ζ-potential. In vitro release studies indicated Mt-BH-LPs effectively maintained a relatively sustained slow release. Immortalized human corneal epithelial cell cytotoxicity, in vivo rabbit eye-irritation tests, and chorioallantoic membrane–trypan blue staining all revealed that Mt-BH-LPs had no obvious irritation on ocular tissues. A new in vitro tear-turnover model, including inserts containing human corneal epithelial cells, was designed to evaluate the precorneal retention time of Mt-BH-LPs. The results showed that Mt-BH-LPs maintained a certain BH concentration in tear fluid for a longer period than the BH solution. In vivo precorneal retention studies also indicated Mt-BH-LPs prolonged drug retention on the ocular surface more than the BH solution. Furthermore, pharmacodynamic studies showed that Mt-BH-LPs had a prolonged effect on decreasing intraocular optical pressure in rabbits. Our results demonstrated that Mt-BH-LPs have potential as an ophthalmic delivery system.

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Layered inorganic nanocomposites: A promising carrier for 5-fluorouracil (5-FU)

Cited by 96 publications

References 28 publications

Structure and Mobility of Lactose in Lactose/Sodium Montmorillonite Nanocomposites

Structure and Mobility of Lactose in Lactose/Sodium Montmorillonite Nanocomposites

Dynamics of Kaolinite-Urea Nanocomposites via Coupled DMSO-Hydroxyaluminum Oligomeric Intermediates

A novel ion-exchange carrier based upon liposome-encapsulated montmorillonite for ophthalmic delivery of betaxolol hydrochloride

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