Layered double hydroxide and sulindac coiled and scrolled nanoassemblies for storage and drug release

Abstract

International audienceSulindac, a non-steroidal anti-inflammatory of the indene acetic acid class, was immobilized inside layered double hydroxide Mg2Al and Zn2Al (LDH) nanovessels through a one pot reaction. LDH–drug materials were characterized by chemical elemental analysis, X-ray diffraction (XRD) (one dimensional electron distribution along the c-stacking axis, pair distribution function analysis), scanning and transmission electron microscopies, mass coupled thermal analyses, vibrational infrared and Raman spectroscopies, and solid state 13C NMR. Density Functional Theory (DFT) calculations were performed for sulindac (protonated and deprotonated forms) with the aim to assign the LDH–drug spectroscopic results. All converge towards a spatial organization of interleaved sulindac molecules close to that reported for the pristine polymorph II crystal structure. Of relevance for human treatment because of its biocompatibility and non-immunogenic effect, in vitro sulindac release experiments were performed in a phosphate buffer mimicking biological fluids and release profiles were refined using kinetic models

Intercalation and structural aspects of macroRAFT agents into MgAl layered double hydroxides

“…However, using the Le Bail method (see Supporting Information File 1), we were able to properly reproduce the profile shapes and widths of the reflections and therefore to extract the intensity of the 00 l diffraction lines reflection, allowing then the calculation of the one-dimensional electron density distribution along the c -stacking axis ρ (z) . As demonstrated elsewhere, this approach can provide valuable information on the structure of the interlayer space [45]. In the present case, up to 8 isolated 00 l reflections are expected at low 2θ (<32°) related to the large value of the interlayer distance d 00 3 ≈ 2.33 nm and assuming a 3R polytype.…”

Investigation of Thermal Behavior of Layered Double Hydroxides Intercalated with Carboxymethylcellulose Aiming Bio-Carbon Based Nanocomposites

“…In this work, composite materials based on MMO/C were prepared at four temperature values (500, 600, 800 and 1000 • C) through pyrolysis of M 2 Al-LDH (M = Mg 2+ or Zn 2+ ) intercalated with CMC, as represented in Figure 2. LDH materials constituted by Mg 2+ /Al 3+ and Zn 2+ /Al 3+ were chosen owing to dissimilar characteristics as thermal stability [22] and topological transformation from LDH to MMO [23,24]. Otherwise, for comparison purposes, LDH materials containing intercalated carbonate instead of CMC were also prepared to investigate the probable influence of CMC on the inorganic phases achieved in the pyrolysis process.…”

Mg–Al and Zn–Al Layered Double Hydroxides Promote Dynamic Expression of Marker Genes in Osteogenic Differentiation by Modulating Mitogen‐Activated Protein Kinases

“…Considering the possibility of controlling the chemical composition of LDH layers and their affinity for anions, drugs, and other biological bioactive species, they have been confined between the inorganic layers for drug delivery and imaging . Our group has been studying experimental parameters for the intercalation of drugs such as pravastatin and sulindac into LDHs and applying structural, spectroscopic, textural, and thermal techniques for their detailed characterization . We recently reported the biological properties of a LDHs intercalated with the anion of mefenamic acid evaluated through the in vitro cytotoxicity tests by hemolysis, and in vivo tests concerning the anti‐inflammatory activity and nociceptive effect of the intercalated and nonintercalated drug .…”