Layered chitosan-collagen hydrogel/aligned PLLA nanofiber construct for flexor tendon regeneration

Deepthi, S.; Sundaram, M. Nivedhitha; Kadavan, J. Deepti; Jayakumar, R.

doi:10.1016/j.carbpol.2016.07.124

Cited by 136 publications

(71 citation statements)

References 40 publications

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“…18 A natural polymer also has a good degradation property to comply with the implant material while a synthetic polymer provides a structural integrity to the nanofiber scaffold to survive in various condition and load bearing. 19,20 Many authors have developed composite naturalsynthetic nanofibers such as poly(L-lactide acid) (PLLA)/Collagen, [21][22][23] PLLA/Chitosan, 19,[24][25][26] and poly-ɛ-caprolactone/chitosan. 27,28 Other natural polymers have been used are chitin, cellulose, alginate, and acid hyaluronic as a polysaccharide source, whereas a gelatine, silk-fibroin, and collagen have been used as protein sources to incorporated with the synthetic polymer.…”

Section: Introductionmentioning

confidence: 99%

Electrospinning of carboxymethyl starch/poly(L‐lactide acid) composite nanofiber

Yusof

Shamsudin

Abdullah

et al. 2018

Polymers for Advanced Techs

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Carboxymethyl starch (CMS) is a natural polymer derived from sago starch that is obtained from sago palm (Metroxylon spp.). Herein, CMS was used as a polysaccharide source in preparations of composite nanofibers with poly(L‐lactide acid) (PLLA). The incorporation of CMS with PLLA in nanofiber form has great potential to be used in biomedical applications. The composite PLLA/CMS nanofibers were fabricated by electrospinning technique at various ratios of CMS, which were 5, 10, 15, and 20% vol/vol. The composite nanofibers were characterized according to their physical morphology, chemical interaction, wettability, water uptake, and thermal and mechanical behaviors. The result showed that uniform and bead‐free nanofibers were produced at the low ratio of CMS while fractal and discontinuing fiber was observed at a high ratio of CMS. A better mechanical strength was obtained at low CMS ratio as compared with higher one. Fourier transform infrared results showed that there was an interaction between CMS and PLLA after electrospinning. The surface hydrophilicity and water uptake increased with increasing ratio of CMS. The results from the differential scanning calorimeter analysis showed the decrease of the glass transition (Tg) and cold crystallization temperature (Tcc) of the nanofiber after addition of CMS in PLLA.

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Section: Introductionmentioning

confidence: 99%

Electrospinning of carboxymethyl starch/poly(L‐lactide acid) composite nanofiber

Yusof

Shamsudin

Abdullah

et al. 2018

Polymers for Advanced Techs

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“…Moreover, the multilayered structure of the packed sheets could mimic the native topography of tendon, therefore the human adipose‐derived stem cells inside the scaffold could remain bioactive and present aligned differentiation with elongated morphology along the fiber arrangement direction. In another study, Jayakumar and co‐workers also fabricated a layered and aligned poly(L‐lactic acid)/chitosan–collagen/alginate composite NFHGs for tendon regeneration …”

Section: Applications Of Nfhgsmentioning

confidence: 99%

“…In another study, Jayakumar and co-workers also fabricated a layered and aligned poly(L-lactic acid)/chitosan-collagen/alginate composite NFHGs for tendon regeneration. [98] On the aspect of ligament tissue repair, Goldstein and coworkers synthesized a cylindrical PLGA/polyethyleneglycol diacrylate (PEGDA) composite hydrogel by electrospinning/electrospraying approach (Figure 10a). [99] PEGDA was introduced into the PLGA nanofibers to improve the hydrophilicity of the PLGA membranes and meanwhile enhances the fiber/hydrogel adhesion strength.…”

Section: Tendon and Ligament Tissue Engineeringmentioning

confidence: 99%

Nanofiber‐Based Hydrogels: Controllable Synthesis and Multifunctional Applications

Duan

Yan

et al. 2018

Macromol. Rapid Commun.

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Nanofiber-based hydrogels (NFHGs) prepared by the combination of traditional hydrogels and novel nanofibers have demonstrated great potential in various application fields, owing to their integrated advantages of superhydrophilicity, high water-holding capacity, good biocompatibility, enhanced mechanical strength, and excellent structural tenability. In this review, a comprehensive overview of the structure design and synthetic strategy of NFHGs derived from electrospinning technique, weaving, freeze-drying, 3D printing, and molecular self-assembling method is provided. The widely researched multifunctional applications, primarily involving tissue engineering, drug delivery, sensing, intelligent actuator, and oil/water separation are also presented. Furthermore, some unsolved scientific issues and possible directions for future development of this field are also intensively discussed.

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“…Hydrogels derived from natural polymers, including CG, have been frequently used and exhibit great potential for delivery of local therapeutic agents …”

Section: Introductionmentioning

confidence: 99%

Positively and Negatively Charged Collagen Nanohydrogels: pH‐responsive Drug‐releasing Characteristics

Kim

Kang

et al. 2018

Bulletin Korean Chem Soc

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Researchers are facing many challenges in developing a strategy for site‐specific delivery in the gastrointestinal tract that can maximize therapeutic response and reduce side effects. The objective of this article was to develop a site‐specific drug delivery system for the gastrointestinal tract using natural polymer collagen (CG). For this, two types of pH‐responsive CG nanohydrogels (negatively charged pH‐CGNH‐COOH and positively charged pH‐CGNH‐NH2) were prepared using negatively and positively functionalized carbon nanotubes, CNT‐COOH and CNT‐NH2, respectively. The pH‐CGNH‐COOH and pH‐CGNH‐NH2 nanohydrogel samples comprising negatively and positively charged fibrils (CG/CNT‐COOH and CG/CNT‐NH2) were physicochemically characterized by Fourier‐transform infrared spectrometry, Zeta sizer, thermogravimetric analysis, and field emission scanning electron microscopy. They also revealed the pH‐responsive release of bovine serum albumin at pH 9 and cytochrome C at pH 2. These results strongly indicate that these drug carriers can be useful for site‐specific delivery in the gastrointestinal tract.

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Layered chitosan-collagen hydrogel/aligned PLLA nanofiber construct for flexor tendon regeneration

Cited by 136 publications

References 40 publications

Electrospinning of carboxymethyl starch/poly(L‐lactide acid) composite nanofiber

Electrospinning of carboxymethyl starch/poly(L‐lactide acid) composite nanofiber

Nanofiber‐Based Hydrogels: Controllable Synthesis and Multifunctional Applications

Positively and Negatively Charged Collagen Nanohydrogels: pH‐responsive Drug‐releasing Characteristics

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