“…Among them are the mitochondrial calcium uniporters (MCUs), which are likely to contribute to the unique calcium dynamics in CA2 pyramidal neuron dendrites (Farris et al, 2019; Simons et al, 2009). Using state‐of‐the‐art imaging techniques, Pannoni et al (2023) follow‐up on this finding in this Special Issue with their discovery that the MCU‐enriched mitochondria are localized to the distal CA2 dendrites where axonal input from the entorhinal cortex forms synapses, suggestive of a novel type of calcium regulation in CA2 at those sites of contact. Also associated with this Special Issue is a manuscript by Samadi, et al, looking at the mechanisms underlying the particularly robust mGluR‐dependent long‐term synaptic depression in CA2, which include a reliance on RGS14 and the striatal enriched tyrosine phosphatase (STEP), which, recall, is also highly expressed in CA2 (Boulanger et al, 1995).…”