Layer-specific and whole wall global longitudinal strain predict major adverse cardiovascular events in patients with stable angina pectoris

Espersen, Caroline; Modin, Daniel; Hoffmann, Søren; Hagemann, Christoffer; Hagemann, Rikke A; Olsen, Flemming Javier; Fritz‐Hansen, Thomas; Platz, Elke; Møgelvang, Rasmus

doi:10.1007/s10554-021-02382-1

Cited by 7 publications

(9 citation statements)

References 36 publications

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“…9,19 GLS and GCS are commonly used 3D-STE strain parameters in clinical diagnosis and treatment. 20,21 This study's results suggest that the 12 m strain parameters GLS and GCS of patients in the Tongxinluo group and the routine group are higher than those in the control group. The 72 h after PCI parameter value increased (p < 0.05), indicating that long-term (≥12 m) drug treatment after PCI in patients with AMI can promote the recovery of left ventricular function in patients with AMI.…”

Section: Discussionmentioning

confidence: 69%

“…Changes in structure and function should be observed to obtain early information on changes in left ventricular function after PCI in AMI patients 9,19 . GLS and GCS are commonly used 3D‐STE strain parameters in clinical diagnosis and treatment 20,21 . This study's results suggest that the 12 m strain parameters GLS and GCS of patients in the Tongxinluo group and the routine group are higher than those in the control group.…”

Section: Discussionmentioning

confidence: 73%

“…GLS and GCS are commonly used 3D-STE strain parameters in clinical diagnosis and treatment [21,22] . This study's results suggest that the 12 m strain parameters GLS and GCS of patients in the Tongxinluo group and the routine group are higher than those in the control group.…”

Section: Discussionmentioning

confidence: 99%

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Three‐dimensional speckle tracking echocardiography to evaluate left ventricular function in patients with acute ST‐segment elevation myocardial infarction after percutaneous coronary intervention following Tongxinluo treatment

Qin

Tian

Jia

et al. 2022

J of Clinical Ultrasound

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Bying comparing the correlation between three-dimensional speckle tracking echocardiography (3D-STE) and three-dimensional left ventricular ejection fraction (LVEF), to explore the 3D-STE to evaluate the left ventricle of patients with acute ST-segment elevation myocardial infarction (acute STEMI) after percutaneous coronary intervention (PCI) following routine treatment with Tongxinluo drugs.Methods: Altogether, 60 patients with acute STEMI and 30 healthy adults were selected, and the patients were randomly divided into the routine group and the Tongxinluo group, with 30 people in each group. All patients underwent PCI, and routine echocardiography and 3D-STE assessments were performed for each group 72 h after PCI and 12 months after PCI to obtain the following left ventricular related functional parameters: left ventricular end-diastolic diameter (LVEDD), end-ventricular septal end-diastolic thickness (IVSD), left ventricular posterior wall end-diastolic thickness (LVPWD), left ventricular short axis shortening fraction (LVFS), Simpson's left ventricular ejection fraction (Simpson's LVEF), three-dimensional left ventricular ejection fraction (3D-LVEF), global longitudinal strain (GLS), global circumferential strain (GCS), left ventricular twist angle (LVtw), Torsion (Tor), peak strain dispersion (PSD), and myocardial comprehensive index (MCI). The same parameters were collected in the control group, the results were compared, and the correlation analysis between GCS, GLS, LVtw, Tor, and MCIF, and 3D-LVE was performed.Results: Compared with the control group, the LVFS, LVEF (Simpson), 3D-LVEF, GLS, GCS, LVtw, Tor, and MCI significantly decreased in patients with STEMI after PCI, while the PSD significantly increased (P<0.05).Compared with the values 72 h after PCI, the LVEDD, LVFS, LVEF (Simpson), 3D-LVEF, GLS, GCS, LVtw, Tor, and MCI significantly increased at 12 m after PCI, while PSD significantly decreased (P <0.05). No significant difference was observed between the two groups at 72 h after PCI (P>0.05). At 12 months after PCI, the LVEF, GLS, GCS, LVtw, Tor, and MCI of the Tongxinluo group were higher than those of the routine group.The PSD was significantly lower in the Tongxinluo group (P<0.05). MCI and 3D-LVEF have the strongest correlation and highest consistency, which can best reflect the changes in the left ventricular function in patients with acute STEMI after PCI. Conclusion:3D-STE can be used to evaluate the protective effect of Tongxinluo on the left ventricular function in patients with acute STEMI after PCI.

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Section: Discussionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 73%

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Three‐dimensional speckle tracking echocardiography to evaluate left ventricular function in patients with acute ST‐segment elevation myocardial infarction after percutaneous coronary intervention following Tongxinluo treatment

Qin

Tian

Jia

et al. 2022

J of Clinical Ultrasound

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“…24 However, prior research has demonstrated greater reproducibility for the acquisition of epicardial GLS compared to endocardial GLS, 25,26 as well as reporting that the epicardium is easier to manually trace. 27 Importantly, the AI image processing pipeline utilised in this study automatically calculates GLS from the endocardium, removing operator dependence and manual identification and correction of image contours, which with greater utilisation may prove clinically important for the risk stratification of high cardiovascular disease patients. If deployed at scale, this technology has potential to provide accurate and accelerated quantitative analysis of variables that normally require specialist training, 12 which combined with prognostic capabilities may culminate in improved clinical workflow, patient care and reduced healthcare costs.…”

Section: Discussionmentioning

confidence: 99%

“…This is likely due to the endocardial layer being the most sensitive to myocardial ischaemia 7 as well as undergoing the greatest deformation change during systole 24 . However, prior research has demonstrated greater reproducibility for the acquisition of epicardial GLS compared to endocardial GLS, 25,26 as well as reporting that the epicardium is easier to manually trace 27 . Importantly, the AI image processing pipeline utilised in this study automatically calculates GLS from the endocardium, removing operator dependence and manual identification and correction of image contours, which with greater utilisation may prove clinically important for the risk stratification of high cardiovascular disease patients.…”

Section: Discussionmentioning

confidence: 99%

Artificial intelligence calculated global longitudinal strain and left ventricular ejection fraction predicts cardiac events and all‐cause mortality in patients with chest pain

O'Driscoll,

Tuttolomondo,

Gaibazzi

2023

Echocardiography

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BackgroundAssessment of left ventricular ejection fraction (LVEF) and myocardial deformation with global longitudinal strain (GLS) has shown promise in predicting adverse cardiovascular events. The aim of this study was to evaluate whether artificial intelligence (AI) calculated LVEF and GLS is associated with major adverse cardiac events (MACE) and all‐cause mortality in patients presenting with chest pain.MethodsWe studied 296 patients presenting with chest pain, who underwent transthoracic echocardiography (TTE). Clinical data, downstream clinical investigations and patient outcomes were collected. Resting TTE images underwent AI contouring for automated calculation of LVEF and GLS with Ultromics EchoGo Core 2.0. Regression analysis was performed to identify clinical and AI calculated parameters associated with MACE and all‐cause mortality.ResultsDuring a median follow‐up period of 7.8 years (IQR 6.4, 8.8), MACE occurred in 34 (11.5%) patients and all‐cause mortality in 60 (20%) patients. AI calculated LVEF (Odds Ratio [OR] .96; 95% CI .93–.99 and .96; 95% CI .93–.99) and GLS (1.11; 95% CI 1.01–1.21 and 1.08; 95% CI 1.00–1.16) were independently associated with MACE and all‐cause mortality, respectively. According to Cox proportional hazards, a LVEF < 50% was associated with a 3.7 times MACE and 2.8 times all‐cause mortality hazard rate compared to those with a LVEF ≥ 50%. Those with a GLS ≥ 15% was associated with a 2.5 times MACE and 2.3 times all‐cause mortality hazard rate compared to those with a GLS ≤ 15.ConclusionAI calculated resting LVEF and GLS is independently associated with MACE and all‐cause mortality in high CVD risk patients. These results may have significant clinical implications through improved risk stratification of patients with chest pain, accelerated workflow of labour‐intensive technical measures, and reduced healthcare costs.

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Usefulness of layer-specific strain for evaluating and predicting recovery of left ventricular myocardial function in patients undergoing hybrid coronary revascularization

Jiang

Zhang

Qin

et al. 2022

Int J Cardiovasc Imaging

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Layer-specific and whole wall global longitudinal strain predict major adverse cardiovascular events in patients with stable angina pectoris

Cited by 7 publications

References 36 publications

Three‐dimensional speckle tracking echocardiography to evaluate left ventricular function in patients with acute ST‐segment elevation myocardial infarction after percutaneous coronary intervention following Tongxinluo treatment

Three‐dimensional speckle tracking echocardiography to evaluate left ventricular function in patients with acute ST‐segment elevation myocardial infarction after percutaneous coronary intervention following Tongxinluo treatment

Artificial intelligence calculated global longitudinal strain and left ventricular ejection fraction predicts cardiac events and all‐cause mortality in patients with chest pain

Usefulness of layer-specific strain for evaluating and predicting recovery of left ventricular myocardial function in patients undergoing hybrid coronary revascularization

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