Layer-by-layer surface modification of lipid nanocapsules

Hirsjärvi, Samuli; Qiao, Yan; Royère, A.; Bibette, Jérôme; Benoit, Jean‐Pierre

doi:10.1016/j.ejpb.2010.07.010

Cited by 34 publications

(31 citation statements)

References 54 publications

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“…In another parallel study, the LNC surface was positively charged using a layer-by-layer approach with lipochitosan as the cationic polymer. 44 Other authors reported similar strategies for other anionic molecules. 45 Blank LNCs have an average diameter (∼50 nm) based on the respective proportions of their components.…”

Section: Discussionmentioning

confidence: 83%

Oral fondaparinux: use of lipid nanocapsules as nanocarriers and in vivo pharmacokinetic study

Ramadan¹,

Lagarce²,

Tessier-Marteau³

et al. 2011

IJN

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Abstract:Oral anticoagulant therapy could be advanced using lipid-based nanoparticulate systems. This study examined lipid nanocapsules for their oral absorption potential as the first step in developing oral fondaparinux (Fp) novel carriers. Using phase inversion method and cationic surfactants such as hexadecyltrimethyl ammonium bromide (CTAB) or stearylamine (SA), cationic lipid nanocapsules (cLNCs), loaded with Fp on their surface, were prepared and characterized (zeta potential, size and Fp association efficiency and content). In vivo studies were conducted after single oral increasing doses of Fp-loaded cLNCs (0.5 to 5 mg/kg of Fp) in rats and the concentration of Fp in the plasma was measured by anti-factor Xa activity assay. The monodisperse, (∼50 nm), positively charged Fp-cLNCs with high drug loadings demonstrated linear pharmacokinetic profiles of the drug with an increased oral absolute bioavailability (up to ∼21%) compatible with therapeutic anticoagulant effect (.0.2 µg/mL).

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Section: Discussionmentioning

confidence: 83%

Oral fondaparinux: use of lipid nanocapsules as nanocarriers and in vivo pharmacokinetic study

Ramadan¹,

Lagarce²,

Tessier-Marteau³

et al. 2011

IJN

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“…Herein, we have selected SBE-β-CD for the following reasons: (i) it is safe for humans as stated by FDAapproval; (ii) greater water solubility compared with β-CD and the derivative methyl-β-CD (www.captisol.com); (iii) strong intermolecular linkages between the negative groups present on SBE-β-CD and the positively charged amino groups of CS lead to highly compacted NPs [19]. Table 1 shows the physicochemical properties of NPs under investigation.…”

Section: Physicochemical Characterization Of Nanoparticlesmentioning

confidence: 99%

“…All obtained samples (unloaded-CSNPs and loaded-CSNPs) were centrifuged for 45 min at 13200 rpm. To promote the adsorption of an additional amount of antibiotic on the loaded-CSNPs surface, a further aliquot of CPX was incubated with the final nanoparticles suspension for 3h at room temperature without any stirring [14,19]. This procedure allowed us to obtain CPX-enriched-loaded-CSNPs (hereafter called loaded-CSNPs-CPX) that were employed for the antibacterial coatings preparation.…”

Section: Preparation Of Chitosan Nanoparticles-based Coatings Onto Timentioning

confidence: 99%

Ciprofloxacin-loaded Chitosan Nanoparticles as Titanium Coatings: A Valuable Strategy to Prevent Implant-associated Infections

Giglio¹,

Trapani²,

Cafagna³

et al. 2012

Nano BioMed ENG

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Orthopaedic infections represent one of the major causes of implant failure. Systemic treatment is limited due to dosing, side-effects, patient compliance, treatment length and resistant bacteria. The choice of antibiotic incorporation method has been the subject of many investigations and, nowadays, various vehicles for local drug delivery have been studied. In this work, a novel ciprofloxacin loaded chitosan nanoparticles coating system onto titanium surface has been developed and characterized. The antibiotic release capability of this system and its ability to inhibit the in vitro growth of two of the most common pathogens causing orthopaedic implant-related infections, Staphylococcus aureus and Pseudomonas aeruginosa, have been evaluated. Preliminary biocompatibility data arising from MG63 osteoblast-like cells seeding on the ciprofloxacin-loaded systems have also been discussed. The investigated system represents a promising candidate in view of the development of new antibiotic carriers in situ for preventing titanium implant-associated infections.Citation: E.De Giglio et al. Ciprofloxacin-loaded chitosan nanoparticles as titanium coatings: a valuable strategy to prevent implant-associated infections.

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“…Functional inorganic nanocrystals in the core of the NCs could allow simultaneous imaging and drug delivery functionalities (57). LbL assembly has proven to be advantageous (17), but alternatives have been proposed without multiple polymers and/or multiple polymer adsorption steps, such as template synthesis (88), providing NCs with thick shells. The nanoprecipitation technique can be used to encapsulate hydrophobic drugs into an amphiphilic copolymer, which can be self-assembled into a micellar structure in an aqueous environment (89).…”

Section: Final Remarksmentioning

confidence: 99%

“…After each coating layer, removal of excess PE can be achieved by different methods. Tangential flow filtration has been proposed for the intermediate purification of the NC dispersion during the LbL process and is a convenient method that retains NC integrity throughout successive purification steps, and does not involve the use of toxic solvents or harsh conditions (17). In addition, a versatile technique for drug encapsulation involves the adsorption of the drug within a porous particle that can subsequently be LbL-coated, and the template (e.g., silica) can be removed, resulting in the formation of NCs with high loading capacities (16).…”

Section: Introductionmentioning

confidence: 99%

Developments in the use of nanocapsules in oncology

Yurgel

Collares

Seixas

2013

Braz J Med Biol Res

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The application of nanotechnology to medicine can provide important benefits, especially in oncology, a fact that has resulted in the emergence of a new field called Nanooncology. Nanoparticles can be engineered to incorporate a wide variety of chemotherapeutic or diagnostic agents. A nanocapsule is a vesicular system that exhibits a typical core-shell structure in which active molecules are confined to a reservoir or within a cavity that is surrounded by a polymer membrane or coating. Delivery systems based on nanocapsules are usually transported to a targeted tumor site and then release their contents upon change in environmental conditions. An effective delivery of the therapeutic agent to the tumor site and to the infiltrating tumor cells is difficult to achieve in many cancer treatments. Therefore, new devices are being developed to facilitate intratumoral distribution, to protect the active agent from premature degradation and to allow its sustained and controlled release. This review focuses on recent studies on the use of nanocapsules for cancer therapy and diagnosis.

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Layer-by-layer surface modification of lipid nanocapsules

Cited by 34 publications

References 54 publications

Oral fondaparinux: use of lipid nanocapsules as nanocarriers and in vivo pharmacokinetic study

Oral fondaparinux: use of lipid nanocapsules as nanocarriers and in vivo pharmacokinetic study

Ciprofloxacin-loaded Chitosan Nanoparticles as Titanium Coatings: A Valuable Strategy to Prevent Implant-associated Infections

Developments in the use of nanocapsules in oncology

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