Layer-by-layer immobilization of amphoteric carboxymethyl chitosan onto biocompatible silk fibroin nanofibrous mats

Tu, Hu; Wu, Guomin; Yang, Yi; Huang, Mengtian; Liu, Rong; Shi, Xiaowen; Deng, Hongbing

doi:10.1016/j.carbpol.2019.01.047

Cited by 67 publications

(13 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast to SS, there are multiple studies that have used SF as a starting material for electrospun wound dressings. SF has been electrospun alone [127,130,140,142,143], in combination with synthetic polymers such as PCL [126,134,137], polyethylenimine (PEI) [129], PVA [131,132], poly(L-lactic acid-co-ecaprolactone) [136], PEO [135,137,138,144,145], and in combination with natural polymers such as gelatin [133] and CS as well as its derivatives [128,138,141] to tune the mechanical and physicochemical properties of the fiber mats (Table 2). In many cases, the electrospun SF-based fibers have been post-treated with ethanol, methanol, acetone or glutaraldehyde to increase β-sheet crystallinity or cross-link the material to improve its water stability [130,132,135,140,142,143].…”

Section: Silk Fibroin and Sericinmentioning

confidence: 99%

Electrospinning Proteins for Wound Healing Purposes: Opportunities and Challenges

Akhmetova

Heinz

2020

Pharmaceutics

View full text Add to dashboard Cite

With the growth of the aging population worldwide, chronic wounds represent an increasing burden to healthcare systems. Wound healing is complex and not only affected by the patient’s physiological conditions, but also by bacterial infections and inflammation, which delay wound closure and re-epithelialization. In recent years, there has been a growing interest for electrospun polymeric wound dressings with fiber diameters in the nano- and micrometer range. Such wound dressings display a number of properties, which support and accelerate wound healing. For instance, they provide physical and mechanical protection, exhibit a high surface area, allow gas exchange, are cytocompatible and biodegradable, resemble the structure of the native extracellular matrix, and deliver antibacterial agents locally into the wound. This review paper gives an overview on cytocompatible and biodegradable fibrous wound dressings obtained by electrospinning proteins and peptides of animal and plant origin in recent years. Focus is placed on the requirements for the fabrication of such drug delivery systems by electrospinning as well as their wound healing properties and therapeutic potential. Moreover, the incorporation of antimicrobial agents into the fibers or their attachment onto the fiber surface as well as their antimicrobial activity are discussed.

show abstract

Section: Silk Fibroin and Sericinmentioning

confidence: 99%

Electrospinning Proteins for Wound Healing Purposes: Opportunities and Challenges

Akhmetova

Heinz

2020

Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…This feature endows chitosan with a self-assembling ability triggered by the formation of polyelectrolyte complexes with polyanions (Quiñones, Peniche, & Peniche, 2018). Due to this ability, chitosan has been extensively studied in the modification of negatively charged surfaces due to electrostatic interaction (Antunes et al, 2011;Tu et al, 2019). Multiple alternating bilayers based on chitosan and sodium alginate (SA) can be easily assembled on CA fibers (Ding, Du, & Hsieh, 2011).…”

Section: Introductionmentioning

confidence: 99%

First report of electrospun cellulose acetate nanofibers mats with chitin and chitosan nanowhiskers: Fabrication, characterization, and antibacterial activity

Pereira

Fajardo

Gerola

et al. 2020

Carbohydrate Polymers

View full text Add to dashboard Cite

Physical adsorption has shown to be facile and highly effective to deposit chitosan nanowhiskers (CsNWs, 60 % deacetylated, length: 247 nm, thickness: 4-12 nm, width:15 nm) on electrospun cellulose acetate nanofibers (CANFs, 560 nm) to effect complete surface charge reversal from negatively charged CANFs (− 40 mV) to positively charged CsNWs-adsorbed CANFs (+8 mV). The CsNWs coverage did not alter the smooth and homogeneous morphology of fibers, as observed from SEM images. Biological assays showed the CsNWs covered nanofibers were effective against the Gram-negative bacterium E. coli, reducing 99 % of colony forming units (CFU) in 24 h and atoxic to healthy Vero cells. The use of CsNWs to modify cellulose fiber surfaces has been proved to be efficient and may be applied to a broad scope of fields, especially as biomaterials and biomedical applications.

show abstract

“…In Figure a, the bands located around 3400 and 1700 cm −1 are attributed to hydroxyl and carbonyl bonds in CNT–COOH, whereas the bands observed at 1400–1600 cm −1 are related to the structure of graphite in CNTs. Figure b indicates the distinctive peaks of fibroin at 1655 cm −1 (amide I), 1513 cm −1 (amide II), and 1235 cm −1 (amide III), confirming that the main structure in fibroin is β‐sheet . Figure c shows the peaks of the fibroin and CNT–COOH.…”

Section: Resultsmentioning

confidence: 99%

Fibroin‐functionalized magnetic carbon nanotube as a green support for anchoring silver nanoparticles as a biocatalyst for A³ coupling reaction

Akbarzadeh

Koukabi

2019

Applied Organom Chemis

View full text Add to dashboard Cite

Novel and powerful fibroin‐functionalized magnetic carbon nanotube–supported silver nanoparticles (CNT–Fe3O4–fibroin–Ag) were successfully synthesized as a nontoxic and inexpensive biocatalyst. The structure of the organic–inorganic hybrid bionanocomposite was characterized by various techniques such as Fourier transform infrared spectroscopy, thermogravimetric analysis, energy‐dispersive X‐ray, field emission‐scanning electron microscopy, transmission electron microscopy, X‐ray diffraction, vibrating sample magnetometry, atomic absorption spectroscopy, and inductively coupled plasma‐optical emission spectrometry. Then, the catalytic activity of synthesized bionanocomposite was evaluated in the three‐component A3 coupling reaction under solvent‐free conditions with good to excellent yields. Several propargylamine derivatives were synthesized by the reaction of different aldehydes with amines and phenylacetylene. Biodegradability, biocompatibility, availability, easy synthesis, high stability, high‐throughput, cost‐effectiveness, and efficient magnetic separation are some advantages of this catalyst that make it economically justified and sustainable. Moreover, the catalyst can be recycled for several runs without appreciable loss in its catalytic activity.

show abstract

Layer-by-layer immobilization of amphoteric carboxymethyl chitosan onto biocompatible silk fibroin nanofibrous mats

Cited by 67 publications

References 34 publications

Electrospinning Proteins for Wound Healing Purposes: Opportunities and Challenges

Electrospinning Proteins for Wound Healing Purposes: Opportunities and Challenges

First report of electrospun cellulose acetate nanofibers mats with chitin and chitosan nanowhiskers: Fabrication, characterization, and antibacterial activity

Fibroin‐functionalized magnetic carbon nanotube as a green support for anchoring silver nanoparticles as a biocatalyst for A³ coupling reaction

Contact Info

Product

Resources

About

Layer-by-layer immobilization of amphoteric carboxymethyl chitosan onto biocompatible silk fibroin nanofibrous mats

Cited by 67 publications

References 34 publications

Electrospinning Proteins for Wound Healing Purposes: Opportunities and Challenges

Electrospinning Proteins for Wound Healing Purposes: Opportunities and Challenges

First report of electrospun cellulose acetate nanofibers mats with chitin and chitosan nanowhiskers: Fabrication, characterization, and antibacterial activity

Fibroin‐functionalized magnetic carbon nanotube as a green support for anchoring silver nanoparticles as a biocatalyst for A3 coupling reaction

Contact Info

Product

Resources

About

Fibroin‐functionalized magnetic carbon nanotube as a green support for anchoring silver nanoparticles as a biocatalyst for A³ coupling reaction