Layer‐by‐layer coating of textile with two oppositely charged cyclodextrin polyelectrolytes for extended drug delivery

Abstract

The coating of a nonwoven textile by polyelectrolyte multilayer film (PEM) issued from cationic and anionic β-cyclodextrin (βCD) polyelectrolytes according to the layer-by-layer (LbL) technique was successfully attempted. The tert-butyl benzoic acid (TBBA) was used as drug model to evaluate the loading capacity and sustained release properties of this PEM system. The build-up of the multilayer assembly was monitored in situ by optical waveguide lightmode spectroscopy (OWLS) on the one hand, and was assessed by gravimetry on the other hand when applied onto the textile substrate. In parallel, the complexation study of TBBA with both CD polyelectrolytes was also investigated by nuclear magnetic resonance (NMR) and isothermal titration calorimetry (ITC). The influence of thermal crosslinking of the multilayered coating on its stability and on TBBA release kinetics in phosphate buffered saline (PBS) at 37°C was studied. Finally, biological and microbiological tests were performed to investigate the cytocompatibility and the intrisic antibacterial activity of multilayer assemblies. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 1408-1424, 2016.

Removal of paraquat herbicide from water by textile coated with anionic cyclodextrin polymer

“…This result could explain the reduction of regeneration efficiency in water for the second cycle due to the extreme loss of polymer coating on the textile surface. This kind of polymer was employed to build the multilayer assembly which showed the fast degradation rate for the multilayer assembly without thermal crosslinking [44]. Other organic solvents displayed less impact than water.…”

“…Cyclodextrin polymers are obtained from polymerization of native cyclodextrin to gain different structures which could give better encapsulation properties than pristine cyclodextrin. Moreover, the addition of charge on cyclodextrin or cyclodextrin polymers allows a good ionic interaction with the opposite charge of the guest molecule [43,44]. Cyclodextrin and their derivatives have fascinated important attention as selective and greater efficiency for environmental applications [45,46] so as to eliminate organic substances or heavy metal [47] such as organic substances [48,49], volatile organic compounds [50,51], dyes [52,53] and pesticides [54,55]).…”

Drug Release Medical Textiles: Fundamentals, Classification and Methods of Fabrication

“…They confirmed the formation of multilayers through the analysis of 2D NMR peaks of the final product. [40]…”

Bio-Functional Textiles: Combining Pharmaceutical Nanocarriers with Fibrous Materials for Innovative Dermatological Therapies

“…In the second case, the microbial growth inhibition is conducted on model bacteria, such as the gram-positive Staphilococcus Aureus or the gram-negative Escherichia Coli , or fungi such as Candida Albicans . The antimicrobial tests are realized according to several standard protocols, and many authors repeated them after washing the textile in order to assess the antimicrobial finishing fastness [172,186,188]. Lastly, non-invasive in-vivo methodologies consist in applying the textile on the skin of human volunteers in the form of a patch test and subsequently obtain data on the skin condition by different methods such as tape striping or transepidermal water loss measurement (TEWL) [189].…”

“…The polyester substrate was preliminarily activated by plasma treatment, and after deposition, the material underwent thermal curing in order to promote the formation of chemical bonds between the oppositely charged cyclodextrins layers. A controlled release profile was assessed by a flow through cell apparatus and cell culture proved both the non-cytotoxicity and the antimicrobial activity [188]. Mihailiasa et al [197] synthesized cyclodextrin nanosponges by chemical crosslinking.…”