Layer by layer assembly of sulfonic poly(ether sulfone) as heparin-mimicking coatings: scalable fabrication of super-hemocompatible and antibacterial membranes

Wang, Lingren; Su, Baihai; Cheng, Chong; Ma, Lang; Li, Shuangsi; Nie, Shengqiang; Zhao, Changsheng

doi:10.1039/c4tb01865f

Cited by 61 publications

(34 citation statements)

References 68 publications

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“…Therefore, there is a need of designing, synthesis and overall property evaluation of novel antibacterial agents. The biocidal property of the materials containing ammonium, imidazolium cations were widely used as disinfectants and cleaning agents in hospital and food industry . The PIL from imidazolium family showed high antimicrobial properties against gram positive bacteria, good blood compatibility, and low cytotoxicity, as well as low adsorption of bovine serum albumin .…”

Section: Introductionmentioning

confidence: 99%

Single‐Step Synthesis of Novel Polyionic Liquids Having Antibacterial Activity and Showing π‐Electron Mediated Selectivity in Separation of Aromatics

Ethirajan¹,

Sengupta

Jebur

et al. 2018

ChemistrySelect

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One‐pot synthesis of polyionic liquids (PILs) from pyridinium and phosphonium family was reported in the present investigation. The size exclusion chromatographic (SEC) method was employed for the determination of the molecular weight of the polymer and the dispersity during synthesis. The aggregation behavior of these PILs was investigated in polar‐ protic, polar‐ aprotic and apolar‐aprotic solvents. The FTIR spectroscopic analysis was utilized for the characterization of the functional groups in PILs, whereas 1H‐NMR analysis was employed for structural characterization of the PILs in terms of the existence of magnetically non‐equivalent protons. UV‐Vis spectroscopic characterization was also employed for these PILs. The anti‐bacterial activity of these PILs were investigated using two gram positive bacteria staphylococcus aureus and pseudomonas aeruginosa. Plate reader method was used to determine the ratio of live to dead bacterial cell in presence of PILs as a function of time by monitoring the fluorescence wave length of the corresponding cells after tagging them suitably with the appropriate dye. The plate counting method was also employed for the direct counting of the number of colony of the bacteria as a function of time in presence of the synthesized PILs. A π‐electron mediated separation was found to bring the selectivity in sorption of aromatics on these PILs.

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Section: Introductionmentioning

confidence: 99%

Single‐Step Synthesis of Novel Polyionic Liquids Having Antibacterial Activity and Showing π‐Electron Mediated Selectivity in Separation of Aromatics

Ethirajan¹,

Sengupta

Jebur

et al. 2018

ChemistrySelect

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“…[1][2][3] However, despite many years of effort, a truly blood compatible material has not yet been developed. The vascular endothelium is the only known surface that is blood compatible in all respects.…”

Section: Introductionmentioning

confidence: 99%

“…2,12 Heparin-like materials have attracted increasing attention for blood contacting applications. 9,13 By analogy with heparin, heparin-like materials are expected to contain ionic functional groups such as sulfonate and carboxylic acid.…”

Section: Introductionmentioning

confidence: 99%

A multifunctional surface for blood contact with fibrinolytic activity, ability to promote endothelial cell adhesion and inhibit smooth muscle cell adhesion

Chen

et al. 2017

J. Mater. Chem. B

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Blood compatible materials are required for a wide variety of medical devices. Despite many years of intensive effort, however, the blood compatibility problem, in particular the ability to prevent thrombosis, remains unsolved. Based on the knowledge that the vascular endothelium, the ultimate blood contacting surface, draws on several mechanisms to maintain blood fluidity, it seems reasonable that analogous multifunctionality should be the goal for blood compatible biomaterials.In the present work, a polyurethane surface was modified with the terpolymer poly(2-hydroxyethyl methacrylate-co-6amino-2-(2-methacylamido)-hexanoic acid-co-1-adamantan-1-yl methyl methacrylate) (poly(HEMA-co-LysMA-co-AdaMA)), referred to as PU-PHLA. Poly(HEMA) and poly(LysMA) were intended to provide, respectively, resistance to non-specific protein adsorption and the ability to lyse incipient clots. The heparin-like moiety, sulfonated β-cyclodextrin was immobilized on the PU-PHLA via host-guest interactions with the poly(AdaMA). This component is expected to inhibit coagulation and smooth muscle cell proliferation and to promote endothelialization. The resulting materials were shown to have multifunctionalities including fibrinolytic activity, anticoagulant activity and the ability to promote endothelial cell adhesion and inhibit smooth muscle cell adhesion. This work provides a new strategy for the development of multifunctional, endothelial-mimicking, biomaterials for blood contacting applications.

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“…10, the improved hydrophilicity of the substrate surface produced by the LbL assemblies was responsible for the bacterial anti-adhesion activity against E. coli. 96 A top-down degradable multifunctional LbL system consisting of two types of multilayers was fabricated for antibacterial applications. 93 Heparin as an anti-adhesive agent with a negative charge and chitosan as a bactericidal agent with a positive charge were alternatively deposited onto aminolyzed poly(ethylene terephthalate) (PET) films to construct anti-adhesive and bacteri- cidal LbL films which were able to reduce the initial adhesion and subsequently the number of viable bacteria (E. coli) effectively.…”

Section: Non-adhesion and Contact Killing Antibacterial Lbl Systemsmentioning

confidence: 99%

Layer-by-layer assemblies for antibacterial applications

2015

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The adhesion and proliferation of bacteria on various artificial surfaces affects the functionality of these specific interfaces. To overcome the problems caused by bacterial growth on these surfaces, various antibacterial coatings were developed. In this review, we summarized most of the antibacterial surfaces prepared by the Layer-by-Layer (LbL) assembly approach and classified these LbL films based on their antibacterial mechanisms. In the first group, the bactericidal LbL assemblies which incorporate various biocides including heavy metals, antibiotics, cationic molecules, antimicrobial peptides and enzymes are able to kill surrounding or contacted bacteria. In the second group, we focused on the physical aspects of film surfaces. Bacterial adhesion resistant LbL films have been fabricated to adjust the substrate surface properties such as surface free energy (or wettability), roughness, and surface charge which may affect the adhesion of bacteria. Furthermore, as an enhancement in the antibacterial efficiency, multifunctional LbL assemblies combining both bactericidal and adhesion resistant functionalities were discussed. The advantages and limitations of these antibacterial LbL assemblies were summarized and subsequently directions for future development were proposed.

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Layer by layer assembly of sulfonic poly(ether sulfone) as heparin-mimicking coatings: scalable fabrication of super-hemocompatible and antibacterial membranes

Abstract: In this study, super-hemocompatible and antibacterial polymeric membranes with surface coated nanofilms were fabricated by LBL assembly of water-soluble heparin-mimicking polymer and quaternized chitosan.

Cited by 61 publications

References 68 publications

Single‐Step Synthesis of Novel Polyionic Liquids Having Antibacterial Activity and Showing π‐Electron Mediated Selectivity in Separation of Aromatics

Single‐Step Synthesis of Novel Polyionic Liquids Having Antibacterial Activity and Showing π‐Electron Mediated Selectivity in Separation of Aromatics

A multifunctional surface for blood contact with fibrinolytic activity, ability to promote endothelial cell adhesion and inhibit smooth muscle cell adhesion

Layer-by-layer assemblies for antibacterial applications

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