Layer‐by‐layer assembly of antibacterial coating on interbonded 3D fibrous scaffolds and its cytocompatibility assessment

Tang, Yanwei; Zhao, Yan; Wang, Hongxia; Gao, Yuan; Liu, Xin; Wang, Xungai; Lin, Tong

doi:10.1002/jbm.a.34116

Cited by 31 publications

(21 citation statements)

References 28 publications

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“…However, the unknown long-term, questionable large- scale applicability, and the complex regulatory pathway still limit this technology. Biodegradable polymers and sol-gel coatings have been shown to provide controlled antibiotic release on titanium 47, 48 or hydroxyapatite implants 49, offering ease of use, versatility, and possible large-scale application. In the present application, the anti-adhesive ability of the DAC hydrogel has been coupled to local antibiotic administration, to reduce the chance for planktonic bacteria to colonize the implant.…”

Section: Discussionmentioning

confidence: 99%

Does an Antibiotic-Loaded Hydrogel Coating Reduce Early Post-Surgical Infection After Joint Arthroplasty?

Cl¹,

Malizos

Capuano³

et al. 2016

J. Bone Joint Infect.

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Background: Infection remains among the main reasons for joint prosthesis failure. Preclinical reports have suggested that antibacterial coatings of implants may prevent bacterial adhesion and biofilm formation. This study presents the results of the first clinical trial on an antibiotic-loaded fast-resorbable hydrogel coating (Defensive Antibacterial Coating, DAC®) in patients undergoing hip or knee prosthesis.Methods: In this multicenter, randomized prospective study, a total of 380 patients, scheduled to undergo primary (n=270) or revision (n=110) total hip (N=298) or knee (N=82) joint replacement with a cementless or a hybrid implant, were randomly assigned, in six European orthopedic centers, to receive an implant either with the antibiotic-loaded DAC coating (treatment group) or without coating (control group). Pre- and postoperative assessment of clinical scores, wound healing, laboratory tests, and x-ray exams were performed at fixed time intervals.Results: Overall, 373 patients were available at a mean follow-up of 14.5 ± 5.5 months (range 6 to 24). On average, wound healing, laboratory and radiographic findings showed no significant difference between the two groups. Eleven early surgical site infections were observed in the control group and only one in the treatment group (6% vs. 0.6%; p=0.003). No local or systemic side effects related to the DAC hydrogel coating were observed, and no detectable interference with implant osteointegration was noted.Conclusions: The use of a fast-resorbable, antibiotic-loaded hydrogel implant coating can reduce the rate of early surgical site infections, without any detectable adverse events or side effects after hip or knee joint replacement with a cementless or hybrid implant.

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Section: Discussionmentioning

confidence: 99%

Does an Antibiotic-Loaded Hydrogel Coating Reduce Early Post-Surgical Infection After Joint Arthroplasty?

Cl¹,

Malizos

Capuano³

et al. 2016

J. Bone Joint Infect.

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“…The ability to adjust pore size and porosity through the ratio of fiber and template particle has provided numerous opportunities to develop 3D scaffolds having optimum pore dimension to suit different cell lines. By using a LbL assembly technique, we also prepared an antibacterial coating on the fiber surface of this 3D scaffold and proved the good matrix‐cell compatibility and antibacterial performance . In addition, we also applied apatite onto the fiber surface to improve the osteoblast response of this scaffold …”

Section: Introductionmentioning

confidence: 95%

Layer-by-layer assembly of silica nanoparticles on 3D fibrous scaffolds: Enhancement of osteoblast cell adhesion, proliferation, and differentiation

Tang

Zhao

Wang

et al. 2013

J. Biomed. Mater. Res.

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Silica nanoparticles were applied onto the fiber surface of an interbonded three-dimensional polycaprolactone fibrous tissue scaffold by an electrostatic layer-by-layer self-assembly technique. The nanoparticle layer was found to improve the fiber wettability and surface roughness. Osteoblast cells were cultured on the fibrous scaffolds to evaluate the biological compatibility. The silica nanoparticle coated scaffold showed enhanced cell attachment, proliferation, and alkaline phosphatase activities. The overall results suggested that interbonded fibrous scaffold with silica nanoparticulate coating could be a promising scaffolding candidate for various applications in bone repair and regeneration.

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“…Biodegradable polymers and sol-gel coatings have also been investigated to provide a controlled antibiotic release on titanium [51,52] or hydroxyapatite implants [53]. However, the most known clinical applications of this approach are probably antibiotic-loaded D-poly-lactate acid/gentamycin intramedullary coated nails that, until now, only showed some positive results in a limited series of patients [17].…”

Section: Discussionmentioning

confidence: 99%

Fast-resorbable antibiotic-loaded hydrogel coating to reduce postsurgical infection after internal osteosynthesis: A multicenter randomized controlled trial

Luca

Kostantinos

Blauth

et al. 2017

Revue de Chirurgie Orthopédique et Traumatologique

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Background Infection is one of the main reasons for failure of orthopedic implants. Antibacterial coatings may prevent bacterial adhesion and biofilm formation, according to various preclinical studies. The aim of the present study is to report the first clinical trial on an antibioticloaded fast-resorbable hydrogel coating (Defensive Antibacterial Coating, DAC Ò ) to prevent surgical site infection, in patients undergoing internal osteosynthesis for closed fractures. Materials and methods In this multicenter randomized controlled prospective study, a total of 256 patients in five European orthopedic centers who were scheduled to receive osteosynthesis for a closed fracture, were randomly assigned to receive antibiotic-loaded DAC or to a control group (without coating). Pre-and postoperative assessment of laboratory tests, wound healing, clinical scores and X-rays were performed at fixed time intervals.Results Overall, 253 patients were available with a mean follow-up of 18.1 ± 4.5 months (range 12-30). On average, wound healing, clinical scores, laboratory tests and radiographic findings did not show any significant difference between the two groups. Six surgical site infections (4.6%) were observed in the control group compared to none in the treated group (P \ 0.03). No local or systemic side-effects related to the DAC hydrogel product were observed and no detectable interference with bone healing was noted. Conclusions The use of a fast-resorbable antibiotic-loaded hydrogel implant coating provides a reduced rate of postsurgical site infections after internal osteosynthesis for closed fractures, without any detectable adverse event or side-effects. Level of evidence 2.

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Layer‐by‐layer assembly of antibacterial coating on interbonded 3D fibrous scaffolds and its cytocompatibility assessment

Cited by 31 publications

References 28 publications

Does an Antibiotic-Loaded Hydrogel Coating Reduce Early Post-Surgical Infection After Joint Arthroplasty?

Does an Antibiotic-Loaded Hydrogel Coating Reduce Early Post-Surgical Infection After Joint Arthroplasty?

Layer-by-layer assembly of silica nanoparticles on 3D fibrous scaffolds: Enhancement of osteoblast cell adhesion, proliferation, and differentiation

Fast-resorbable antibiotic-loaded hydrogel coating to reduce postsurgical infection after internal osteosynthesis: A multicenter randomized controlled trial

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