Layer‐by‐Layer Assembled Multilayer Films of Methoxypoly(ethylene glycol)‐block‐poly(α,L‐glutamic acid) and Chitosan with Reduced Cell Adhesion

Abstract

A methoxypoly(ethylene glycol)-block-poly(α,L-glutamic acid) (mPEGGA) diblock copolymer is synthesized. Using QCM measurements, it is shown that (CS/mPEGGA)(n) film construction takes place over two build-up stages (exponential-to-linear). UV-vis spectra reveal the regular increase of the multilayer film growth at different molecular weights of mPEGGA. Contact angle and surface morphology investigation prove that the hydrophilicity of CS/mPEGGA multilayer film-modified substrate becomes better and the surface becomes rough. Significantly reduced cell adhesion is observed on the CS/mPEGGA multilayer film coated surface.

Fabrication of poly(l-glutamic acid)/chitosan polyelectrolyte complex porous scaffolds for tissue engineering

“…Polyelectrolyte complexation between PLGA (or its copolymers) and chitosan (CS) in the form of lm, nanoparticles and microcapsules has been scrutinized in our previous work. [7][8][9][10][11][12] Multilayered lms developed from PLGA or poly(acrylic acid)-b-poly-(L-glutamic acid) (PAA-b-PLGA)/CS showed excellent biocompatibility and cell adhesive properties. Although PLGA/CS scaffolds with a porous structure were expected to be prepared based on electrostatic interaction, directly mixing PLGA and CS solutions oen results in immediate formation of polyelectrolyte complexes at the interfaces with a huge aggregate precipitating from the solution in the preparation process.…”

pH and Redox Dual-Stimulated Wormlike Micelles Based on Cystamine and Conventional Anionic Surfactant

“…The disulfide bond, which is responsive to reducing agents, strong oxidizers, and light, plays an important role in peptide chains and protein structures. A special class of disulfide-containing surfactants and macromolecules has been synthesized by several researchers. − The amphiphiles containing disulfide bonds have potential applications in functional materials, ,, biomedicine, and drug release. ,, Recently, Li reported a responsive WLM system constructed by disulfide-containing polymers, and the multiresponsiveness of the WLMs improves the therapeutic effect on brain tumors . Nevertheless, the disulfide-containing WLMs constructed by small-molecule surfactants are less documented.…”

Biodegradable polymer–platinum drug conjugates to overcome platinum drug resistance

“…11,12 Although poly(ethylene glycol)-block-poly(glutamic acid) is biodegradable and water soluble (hydrophilic), it can self assemble into micelles with the Pt atoms as the cross-linking points. 15,16 The exceptional physico-chemical and biological properties of the cisplatin-loaded micelle indicate them as an outstanding delivery system for cisplatin complexes and a phase I clinical trial has recently been completed in the UK (NC-6004, Nanocarrier Co. Ltd, Japan). 17,18 We focus on biodegradable but amphiphilic polymers for platinum drug delivery.…”