Lawsonella clevelandensis is a rare cause of infected chronic contained rupture of abdominal aortic aneurysm

Ahmed, Wissam; Dewar, Simon; Williams, Robin; Stansby, Gerard; Harris, Kathryn; Weiand, Daniel

doi:10.1099/acmi.0.000183

Cited by 3 publications

(2 citation statements)

References 11 publications

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“…L. clevelandensis has been detected in multiple human sources associated with health issues, including dermatitis 20 , various abscesses [21][22][23][24][25] , gut dysbiosis 26 , or vascular graft infection [27][28][29] . Other studies showed that the bacterium can be found in the microbiome of skin 30 , nostrils 31 , human hair follicles 32 , public transit air 33 or even worn spectacles 34 .…”

Section: Discussionmentioning

confidence: 99%

“…22 As such, conventional culture techniques often fail to isolate the bacterium. 28,29 Once successfully cultured, the differentiation of L. clevelandensis from non-tuberculous mycobacteria is still demanding due to its partial acid resistance. 21 Therefore, even if diagnostic microbiology laboratories target the pathogen, culturing, and identification during the routine bacteriological testing period is unlikely.…”

Section: Discussionmentioning

confidence: 99%

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First animal source metagenome assembly ofLawsonella clevelandensisfrom canine external otitis

Tóth,

Solymosi,

Tenk

et al. 2023

Preprint

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External otitis is one of the most common conditions in dogs to be presented to the veterinarian. Moreover, the disorder is often difficult to manage. The range and role of microorganisms involved in the pathogenesis are currently not fully understood. Therefore, the condition has been studied using third-generation sequencing (Oxford Nanopore Technology) to gain a more complete picture of the pathogens involved. Throughout the metagenome assembly of a sample harvested from the ear canal of an 11-year-old female Yorkshire terrier suffering from chronic external otitis, a genome ofLawsonella clevelandensiswas compiled. To our knowledge, this result is the first of its type of animal origin. The outcome of the assembly (CP140010) is a single circular chromosome with a length of 1,878,509 bp, and 1,826 predicted protein-coding genes. No open reading frames associated with antimicrobial resistance could have been identified.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

First animal source metagenome assembly ofLawsonella clevelandensisfrom canine external otitis

Tóth,

Solymosi,

Tenk

et al. 2023

Preprint

View full text Add to dashboard Cite

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Lawsonella clevelandensis, a case series of vascular graft infections caused by a rare pathogen

Nour

Khodadadi

Schuetz

et al. 2023

IDCases

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Microbiota of Urine, Glans and Prostate Biopsies in Patients with Prostate Cancer Reveals a Dysbiosis in the Genitourinary System

Gonçalves

Pina‐Vaz

Fernandes

et al. 2023

Cancers

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Prostate cancer (PCa) is the most common malignant neoplasm with the highest worldwide incidence in men aged 50 years and older. Emerging evidence suggests that the microbial dysbiosis may promote chronic inflammation linked to the development of PCa. Therefore, this study aims to compare the microbiota composition and diversity in urine, glans swabs, and prostate biopsies between men with PCa and non-PCa men. Microbial communities profiling was assessed through 16S rRNA sequencing. The results indicated that α-diversity (number and abundance of genera) was lower in prostate and glans, and higher in urine from patients with PCa, compared to non-PCa patients. The different genera of the bacterial community found in urine was significantly different in PCa patients compared to non-PCa patients, but they did not differ in glans and prostate. Moreover, comparing the bacterial communities present in the three different samples, urine and glans show a similar genus composition. Linear discriminant analysis (LDA) effect size (LEfSe) analysis revealed significantly higher levels of the genera Streptococcus, Prevotella, Peptoniphilus, Negativicoccus, Actinomyces, Propionimicrobium, and Facklamia in urine of PCa patients, whereas Methylobacterium/Methylorubrum, Faecalibacterium, and Blautia were more abundant in the non-PCa patients. In glans, the genus Stenotrophomonas was enriched in PCa subjects, while Peptococcus was more abundant in non-PCa subjects. In prostate, Alishewanella, Paracoccus, Klebsiella, and Rothia were the overrepresented genera in the PCa group, while Actinomyces, Parabacteroides, Muribaculaceae sp., and Prevotella were overrepresented in the non-PCa group. These findings provide a strong background for the development of potential biomarkers with clinical interest.

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Lawsonella clevelandensis is a rare cause of infected chronic contained rupture of abdominal aortic aneurysm

Cited by 3 publications

References 11 publications

First animal source metagenome assembly ofLawsonella clevelandensisfrom canine external otitis

First animal source metagenome assembly ofLawsonella clevelandensisfrom canine external otitis

Lawsonella clevelandensis, a case series of vascular graft infections caused by a rare pathogen

Microbiota of Urine, Glans and Prostate Biopsies in Patients with Prostate Cancer Reveals a Dysbiosis in the Genitourinary System

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