Lawsone-encapsulated chitosan/polyethylene oxide nanofibrous mat as a potential antibacterial biobased wound dressing

Abadehie, Fatemeh Saniee; Dehkordi, Ali Hasanpour; Zafari, Mahdi; Bagheri, Mitra; Yousefiasl, Satar; Pourmotabed, Samiramis; Mahmoodnia, Leila; Validi, Majid; Ashrafizadeh, Milad; Zare, Ehsan Nazarzadeh; Rabiee, Navid; Makvandi, Pooyan; Sharifi, Esmaeel

doi:10.1016/j.engreg.2022.01.001

Cited by 45 publications

(39 citation statements)

References 45 publications

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“…The mixture was stirred at 500 rpm, and the organic phase was evaporated to dryness in an oil bath 95°C to obtain Micelle IR780 . [4] M I @CaP D were fabricated by combining two solutions. [42] Solution A consisted of 0.42 mL of CaCl 2 (2 M), 0.84 mL of Tris buffer (pH = 10, 10 mM) and 2 mL of M I .…”

Section: Methodsmentioning

confidence: 99%

“…The mixture was stirred at 500 rpm, and the organic phase was evaporated to dryness in an oil bath 95℃ to obtain Micelle IR780 . [ 4 ]…”

Section: Methodsmentioning

confidence: 99%

“…Chronic wound infections can delay the healing process and place a significant burden on the global medical system. [1][2][3][4] It has been demonstrated that 80% of persistent chronic microbial infections are often closely associated with firm bacterial biofilms. [5] Biofilm is a structural and functional bacterial community composed of microbial cells and the surrounding extracellular polymeric substances (EPS) such as exopolysaccharides, protein, and extracellular DNA (eDNA).…”

Section: Introductionmentioning

confidence: 99%

“…[27,28] Furthermore, DNase I has insufficient bactericidal effect, and it should be combined with a strong antibacterial therapeutic as a combination. [15] Herein, we designed an enzyme/NIR dye composite nanoplatform [4] with enhanced EPS hydrolysis function and NIR-mediated antibacterial capacity for biofilm gradient elimination. As shown in Figure 1, the IR780 was first encapsulated inside hydrophobic core of DSPE-PEG 2000 micelles to enhance its solubility.…”

Section: Introductionmentioning

confidence: 99%

“…Herein, we designed an enzyme/NIR dye composite nanoplatform [ 4 ] with enhanced EPS hydrolysis function and NIR‐mediated antibacterial capacity for biofilm gradient elimination. As shown in Figure 1, the IR780 was first encapsulated inside hydrophobic core of DSPE‐PEG 2000 micelles to enhance its solubility.…”

Section: Introductionmentioning

confidence: 99%

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Ca²⁺ enhanced photosensitizer/DNase I nanocomposite mediated bacterial eradication through biofilm disruption and photothermal therapy

et al. 2022

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Biofilms are currently responsible for 80% of human chronic bacterial infections, being composed of bacterial communities within self-produced extracellular polymeric substances (EPS) that can resist various adverse factors in the bacterial microenvironment. Therefore, the development of powerful antibacterial systems by disrupting biofilms first and killing exposed free-living bacteria is the top priority for clinical antibiotic needs. In this study, we developed a pH-and photothermally responsive photosensitizer/enzyme-loaded nanocomposite for enhanced biofilm disruption and bacteria killing (gram-positive and gram negative). To achieve this, IR780 (I) as an efficient NIR dye was encapsulated inside the hydrophobic core of 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycerol)-2000] (DSPE-PEG 2000 ) micelles (M) for enhanced photothermal therapy. EPS extracellular DNA lyase deoxyribonuclease I (DNase I) was anchored on the micellar surface by calcium phosphate mineralization method. The results indicated that pH-sensitive M I @CaP D nanocomposite degraded as a response to the acidic conditions characteristic for the bacterial environment and released DNase I and Ca 2+ ions simultaneously. Subsequently, the Ca 2+ stabilized the DNase I active structure and facilitated the dispersion of the biofilm EPS. Then, interior bacteria were exposed and killed by IR780-mediated hyperthermia. The synergistic effect of DNase I and photothermal therapy could efficiently eradicate the biofilms, which exhibits superior biofilm dispersion and destruction capability.

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Section: Methodsmentioning

confidence: 99%

“…The mixture was stirred at 500 rpm, and the organic phase was evaporated to dryness in an oil bath 95℃ to obtain Micelle IR780 . [ 4 ]…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Ca²⁺ enhanced photosensitizer/DNase I nanocomposite mediated bacterial eradication through biofilm disruption and photothermal therapy

et al. 2022

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Flexible 3D Nanonetworked Silica Film as a Polymer‐Free Drug‐Eluting Stent Platform to Effectively Suppress Tissue Hyperplasia in Rat Esophagus

Jeon

Kang

Bae

et al. 2022

Adv Healthcare Materials

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Loading and eluting drugs on self‐expandable metallic stents (SEMSs) can be challenging in terms of fabrication, mechanical stability, and therapeutic effects. In this study, a flexible 3D nanonetworked silica film (NSF) capable of withstanding mechanical stress during dynamic expansion is constructed to function as a drug delivery platform on an entire SEMS surface. Despite covering a broad curved area, the synthesized NSF is defect‐free and thin enough to increase the stent strut diameter (110 µm) by only 0.4 percent (110.45 µm). The hydrophobic modification of the surface enables loading of 4.7 times the sirolimus (SRL) concentration in NSF than Cypher, polymer‐coated commercial stent, which is based on the same thickness of coating layer. Furthermore, SRL‐loaded NSF exhibits a twofold delay in release compared to the control group without NSF. The SRL‐loaded NSF SEMS significantly suppresses stent‐induced tissue hyperplasia than the control SEMS in the rat esophagus (all variables, p < 0.05). Thus, the developed NSF is a promising polymer‐free drug delivery platform to efficiently treat esophageal stricture.

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CuS@TA‐Fe Nanoparticle‐Doped Multifunctional Hydrogel with Peroxide‐Like Properties and Photothermal Properties for Synergistic Antimicrobial Repair of Infected Wounds

Zhou,

Chen,

et al. 2023

Adv Healthcare Materials

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Bacterial infection is a critical factor in wound healing. Due to the abuse of antibiotics, some pathogenic bacteria have developed resistance. Thus, there is an urgent need to develop a non‐antibiotic‐dependent multifunctional wound dressing for the treatment of bacteria‐infected wounds. In this work, a multifunctional AOCuT hydrogel embedded with CuS@TA‐Fe nanoparticles (NPs) through Schiff base reaction between gelatin quaternary ammonium salt – gallic acid (O‐Gel‐Ga) and sodium dialdehyde alginate (ADA) along with electrostatic interactions with CuS@TA‐Fe NPs is prepared. These composite hydrogels possess favorable injectability, rapid shape adaptation, electrical conductivity, photothermal antimicrobial activity, and biocompatibility. Additionally, the doped NPs not only impart fast self‐healing properties and excellent adhesion performance to the hydrogels, but also provide excellent peroxide‐like properties, enabling them to scavenge free radicals and exhibit anti‐inflammatory and antioxidant capabilities via photothermal (PTT) and photodynamic (PDT) effects. In an S. aureus infected wound model, the composite hydrogel effectively reduces the expression level of wound inflammatory factors and accelerates collagen deposition, epithelial tissue, and vascular regeneration, thereby promoting wound healing. This safe and synergistic therapeutic system holds great promise for clinical applications in the treatment of infectious wounds.

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Lawsone-encapsulated chitosan/polyethylene oxide nanofibrous mat as a potential antibacterial biobased wound dressing

Cited by 45 publications

References 45 publications

Ca²⁺ enhanced photosensitizer/DNase I nanocomposite mediated bacterial eradication through biofilm disruption and photothermal therapy

Ca²⁺ enhanced photosensitizer/DNase I nanocomposite mediated bacterial eradication through biofilm disruption and photothermal therapy

Flexible 3D Nanonetworked Silica Film as a Polymer‐Free Drug‐Eluting Stent Platform to Effectively Suppress Tissue Hyperplasia in Rat Esophagus

CuS@TA‐Fe Nanoparticle‐Doped Multifunctional Hydrogel with Peroxide‐Like Properties and Photothermal Properties for Synergistic Antimicrobial Repair of Infected Wounds

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Lawsone-encapsulated chitosan/polyethylene oxide nanofibrous mat as a potential antibacterial biobased wound dressing

Cited by 45 publications

References 45 publications

Ca2+ enhanced photosensitizer/DNase I nanocomposite mediated bacterial eradication through biofilm disruption and photothermal therapy

Ca2+ enhanced photosensitizer/DNase I nanocomposite mediated bacterial eradication through biofilm disruption and photothermal therapy

Flexible 3D Nanonetworked Silica Film as a Polymer‐Free Drug‐Eluting Stent Platform to Effectively Suppress Tissue Hyperplasia in Rat Esophagus

CuS@TA‐Fe Nanoparticle‐Doped Multifunctional Hydrogel with Peroxide‐Like Properties and Photothermal Properties for Synergistic Antimicrobial Repair of Infected Wounds

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Product

Resources

About

Ca²⁺ enhanced photosensitizer/DNase I nanocomposite mediated bacterial eradication through biofilm disruption and photothermal therapy

Ca²⁺ enhanced photosensitizer/DNase I nanocomposite mediated bacterial eradication through biofilm disruption and photothermal therapy