Lawrence G. Raisz November 13, 1925–August 25, 2010

Bilezikian, John P.; Drezner, Marc K.; Kream, Barbara E.; Stern, Paula H.; Clemens, Thomas L.; Elderkin, Ann; Siris, Ethel S.; Krane, Stephen M.; Eisman, John A.; Arnold, Andrew; Feyen, Jean H.M.; Hurley, Marja M.; Kawaguchi, Hiroshi; Lorenzo, Joe; Peck, William A.; Pilbeam, Carol C.; Martin, Trish; Hock, Janet M.; DeLuca, Hector; Rodan, Sevgi B.; Lukert, Barbara P.; Chen, Theresa; Klein‐Nulend, Jenneke

doi:10.1002/jbmr.368

Cited by 2 publications

(1 citation statement)

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“…For each phenotype marker investigated, the preosteoblasts on the composite scaffold demonstrated an appropriate onset and attenuation with what is to be expected for a maturing osteoblast, whereas the preosteoblasts on the control sintered microsphere scaffolds only demonstrated the onset of the early markers, alkaline phosphatase, and osteopontin. 23,24 In addition, the immature osteoblasts on the control scaffolds produced approximately half the amount of total scaffold calcification compared with the mature osteoblasts on the composite scaffolds.…”

Section: Discussionmentioning

confidence: 98%

Composite scaffolds: Bridging nanofiber and microsphere architectures to improve bioactivity of mechanically competent constructs

Brown

Peach

Nair

et al. 2010

J Biomedical Materials Res

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Tissue engineering often benefits from the use of composites to produce an ideal scaffold. We present the focused development of a novel structure that combines the biomimetic properties of nanofibers with the robust mechanical aspects of the sintered microsphere scaffold to produce a composite scaffold that demonstrates an ability to mimic the mechanical environment of trabecular bone while also promoting the phenotype progression of osteoblast progenitor cells. These composite nanofiber/microsphere scaffolds exhibited a mechanical modulus and compressive strength similar to trabecular bone and exhibited degradation resulting in a mass loss of 30% after 24 weeks. The nanofiber portion of these scaffolds was sufficiently porous to allow cell migration throughout the fibrous portion of the scaffold and promoted phenotype progression through focal adhesion kinase-mediated activation of the transcription factor Runx2, control scaffolds not containing nanofibers did not demonstrate extensive cell migration or phenotype progression. Ultimately, the focal adhesion kinase activity on the composite nanofiber/microsphere scaffolds demonstrated causality over the production of the mature osteoblast marker, osteocalcin, and the development of a calcified matrix.

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Section: Discussionmentioning

confidence: 98%

Composite scaffolds: Bridging nanofiber and microsphere architectures to improve bioactivity of mechanically competent constructs

Brown

Peach

Nair

et al. 2010

J Biomedical Materials Res

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Hypoparathyroidism: is it that easy to treat?

et al. 2018

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Hypoparathyroidism is a relatively rare endocrine disease characterised by either null or inappropriately low secretion of parathyroid hormone (PTH) for serum calcium levels. The other main laboratory findings include hypocalcaemia, inappropriately normal or high urine calcium excretion and hyperphosphataemia with low urine phosphate excretion. The management of hypoparathyroidism should be tailored to each individual case, which makes it a demanding undertaking in everyday clinical practice. In this review, we sought to focus on the diagnostic approach of hypoparathyroidism and the therapeutic challenges of the disease from a clinical perspective. Conventional treatment with vitamin D analogues and calcium salts is no longer the only available treatment, since replacement treatment with PTH(1-84) has recently been approved for the disease. However, the optimal treatment schedule is yet to be defined.

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Lawrence G. Raisz November 13, 1925–August 25, 2010

Cited by 2 publications

References 0 publications

Composite scaffolds: Bridging nanofiber and microsphere architectures to improve bioactivity of mechanically competent constructs

Composite scaffolds: Bridging nanofiber and microsphere architectures to improve bioactivity of mechanically competent constructs

Hypoparathyroidism: is it that easy to treat?

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