Lawesson's Reagent

Abstract

Lawesson's reagent is a powerful, mild, and versatile thiation (also called thionation or sulfuration) agent that efficiently converts oxygen functionalities into their thio ‐analogs. The full name of this reagent 2,4‐bis(4‐methoxyphenyl)‐1,3,2,4‐dithiadiphosphetane 2,4‐disulfide (or ‐disulphide) besides this various name of this reagent have been suggested. Several applications of this reagent have been presented, such as it converts the carbonyl group into thiocarbonyl group, carbon‐oxygen single bond into a carbon‐sulfur single bond, etc. This reagent has been used for the cyclization of compounds containing at least two oxygen functionalities. It does have also some disadvantages during functional group transformation.

Conformational Features of Thioamide-Containing Dipeptoids and Peptoid–Peptide Hybrids—Computational and Experimental Approaches

“…The general scheme for the synthesis of the model compounds is shown in Scheme . It comprises steps that are typical of short peptoid synthesis in solution combined with the steps of conversion of the amide to the thioamide group using Lawesson’s reagent. , A detailed description of the synthetic procedures and NMR spectra ( 1 H NMR, CD 2 Cl 2 ) of the synthesized products are presented in the Supporting Information.…”