Lavender oil (Lavandula angustifolia) attenuates renal ischemia/reperfusion injury in rats through suppression of inflammation, oxidative stress and apoptosis

Aboutaleb, Nahid; Jamali, Hossein; Abolhasani, Maryam; Toroudi, Hamidreza Pazoki

doi:10.1016/j.biopha.2018.11.045

Cited by 61 publications

(34 citation statements)

References 40 publications

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“…At 8 hours after E. coli infection, the expression of TNF-α and IL-1β in the liver from Plt Clec2 -/mice was significantly higher than that in the liver of WT mice (Figure 2, A and C). TNF-α and IL-1β staining were performed using cryosections of liver tissues collected at 8 hours after E. coli infection based on published methods (28)(29)(30), revealing that CLEC-2 deficiency increased the expression of TNF-α and IL-1β in the liver of infected mice, which partially overlapped with macrophages (F4/80-positive) ( Figure 2, B and D; and Supplemental Figure 3, A and B). Thus, platelet CLEC-2 deficiency enhanced inflammation in the liver in early sepsis.…”

Section: Resultsmentioning

confidence: 99%

Monocyte upregulation of podoplanin during early sepsis induces complement inhibitor release to protect liver function

et al. 2020

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Section: Resultsmentioning

confidence: 99%

Monocyte upregulation of podoplanin during early sepsis induces complement inhibitor release to protect liver function

et al. 2020

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“…In the meantime, the release of inflammatory mediators is another pivotal contributor to cell death during IR injury. After reperfusion, inflammatory cell infiltration in injured tissues is responsible for the production of inflammatory factors, including TNF-a and IL-6, which subsequently trigger a feedback loop in inflammatory cascades, leading to tissue dysfunction and damage (Aboutaleb et al, 2019). Moreover, inflammatory cytokines can further activate the immune/ inflammatory response and result in the extension of injury (Zhao et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Dietary Nitrate Protects Against Skin Flap Ischemia-Reperfusion Injury in Rats via Modulation of Antioxidative Action and Reduction of Inflammatory Responses

et al. 2020

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Dietary nitrate, found abundant in green vegetables, can be absorbed into the blood and be converted to nitric oxide (NO) in the body. Dietary nitrate has been proved to have many positive physiological functions in the body. Here, we evaluated the therapeutic effects of dietary nitrate on skin flap recovery following ischemia reperfusion (IR). Wistar rats were pretreated with nitrate from one week prior to ischemia to the end of reperfusion. It was found that oral administration of nitrate increased serum nitrate and nitrite levels, protected cells from apoptosis, and attenuated flap tissue edema. In the meantime, the oxidative stress marker malondialdehyde was reduced, while the activities of antioxidant enzymes were restored after nitrate treatment. Moreover, the macrophage and neutrophil infiltration in the flap was significantly attenuated by nitrate supplementation, as were the pro-inflammatory cytokines. In sum, we found that oral administration of nitrate can attenuate skin flap IR injury through the regulation of oxidative stress and inflammatory response.

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“…In animal models, lavender administration reduced inflammation and neuropathic pain via its effect on peripheral and central opioid and cannabinoid 2 receptors (Donatello et al, 2020). In another animal study, following renal ischemia/reperfusion injury, lavender oil markedly restored antioxidant enzyme activity, reduced lipid peroxidation, and significantly decreased levels of the cytokines, tumour necrosis factor‐α and interleukin‐1β (Aboutaleb, Jamali, Abolhasani, & Pazoki Toroudi, 2019). In another acute inflammatory animal model, lavender also had anti‐inflammatory effects via its influence on prostanoids, nitric oxide, proinflammatory cytokines, and histamine (Cardia et al, 2018).…”

Section: Resultsmentioning

confidence: 99%

Herbal treatments for migraine: A systematic review of randomised‐controlled studies

Lopresti

Smith

Drummond

2020

Phytotherapy Research

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Herbal treatments are often used as a treatment for migraine. Therefore, an evaluation of their safety and efficacy is important. Based on the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines, and Cochrane Collaboration's tool for assessing the risk of bias, a systematic literature review of randomised, controlled human trials assessing the effects of herbal treatments delivered as a single ingredient for the acute or prophylactic treatment of migraine were conducted. Studies were identified through electronic database searches on Medline (Pubmed), Cochrane Library, Scopus, and CINAHL. Nineteen studies were identified examining the effects on migraine of feverfew, butterbur, curcumin, menthol/peppermint oil, coriander, citron, Damask rose, chamomile, and lavender. Overall, findings on the efficacy of feverfew were mixed and there was positive, albeit limited evidence for butterbur. There were positive, preliminary findings on curcumin, citron, and coriander as a prophylactic treatment for migraine, and the use of menthol and chamomile as an acute treatment. However, the risk of bias was high for many studies. The results of this systematic review suggest that several herbal medicines, via their multifactorial physiological influences, present as potential options to enhance the treatment of migraine. However, further high‐quality research is essential to examine their efficacy and safety as a treatment for migraine.

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Lavender oil (Lavandula angustifolia) attenuates renal ischemia/reperfusion injury in rats through suppression of inflammation, oxidative stress and apoptosis

Cited by 61 publications

References 40 publications

Monocyte upregulation of podoplanin during early sepsis induces complement inhibitor release to protect liver function

Monocyte upregulation of podoplanin during early sepsis induces complement inhibitor release to protect liver function

Dietary Nitrate Protects Against Skin Flap Ischemia-Reperfusion Injury in Rats via Modulation of Antioxidative Action and Reduction of Inflammatory Responses

Herbal treatments for migraine: A systematic review of randomised‐controlled studies

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