Laurel (Laurus nobilis L.): A Less-Known Medicinal Plant to the World with Diffusion, Genomics, Phenomics, and Metabolomics for Genetic Improvement

Nadeem, Muhammad Azhar; Aasım, Muhammad; Kirici, Saliha; Karik, Ünal; Nawaz, Muhammad Amjad; Yılmaz, Abdurrahim; Maral, Hasan; Khawar, Khalid Mahmood; Baloch, Faheem Shehzad

doi:10.1007/978-981-13-0535-1_28

Cited by 12 publications

(1 citation statement)

References 65 publications

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“…Laurus nobilis L. (LNL), which belongs to the Lauraceae family Laurus L., originates from the Mediterranean coast and has been widely used as a seasoning and spice in the past [25,26]. In Korea, it is cultivated in southern regions, such as Jeollanam-do and Wando [27].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Laurus nobilis L. for Tight Junction Protein Imbalance in Leaky Gut Syndrome

Shin,

Kim,

Song

et al. 2024

Nutrients

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Laurus nobilis L. (LNL) belongs to the evergreen Lauraceae family. It is native to the Mediterranean and widely distributed in the southern United States, Europe, and the Middle East. LNL is rich in active ingredients of the sesquiterpene lactone series and has been reported to have antioxidant, anti-inflammatory, and anticancer effects. And parthenolide, known as a sesquiterpene lactone-based compound, inhibits the activation of lipopolysaccharide-binding protein (LBP), which is a major trigger for leaky gut syndrome. However, the effectiveness of LNL in improving the state of increased intestinal permeability has not yet been reported. Therefore, we demonstrated the efficacy of LNL, which is known to be rich in parthenolide, in improving intestinal permeability induced by IL-13. We investigated the improvement in permeability and analyzed major tight junction proteins (TJs), permeability-related mechanisms, weight and disease activity indices, and corresponding cytokine mechanisms. LNL maintained TJs homeostasis and clinical improvement by reducing increased claudin-2 through the inhibition of IL-13/STAT6 activation in TJ-damaged conditions. These results are expected to be effective in preventing leaky gut syndrome through the TJ balance and to further improve intestinal-related diseases, such as inflammatory bowel disease.

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Section: Introductionmentioning

confidence: 99%