Objectives The objective of this study is to explore the attitudes, involvement, and knowledge of international medical students regarding research, as well as the barriers they face. Methods This is a cross-sectional survey that involves a selfadministered anonymous questionnaire with international medical students. Results A total of 221 adequately filled surveys were returned, 128 from high-income and 93 from low-and middle-income countries. Even though about 70 % of students were interested in research, only about half were involved in research in medical school, mostly in terms of literature review. Also, only about 25 % on average were confident about their research knowledge. About 80 % considered setting up formal groups to teach research in a systematic and structured way to be the best way to enhance student research. Most common obstacles facing students were lack of time, lack of funds, and lack of support. For most variables, no significant differences were found between high-and low-income groups.Conclusions Most international medical students are interested in research. Knowledge defects are evident and may be contributing to the decreased rate of involvement in research activities. Our study indicates that the best way to promote research might be by teaching it in a structured and systematic way.