LATTICE Radiotherapy with RapidArc for Treatment of Gynecological Tumors:Dosimetric and Early Clinical Evaluations

Amendola, Beatriz E.; Pérez, Naipy; Amendola, Marco A.; Wu, Xiaodong; Ahmed, Mansoor M.; Iglesias, Alejandro; Estape, Richard; Lambrou, Nicholas C; Bortoletto, Pietro

doi:10.7759/cureus.15

Cited by 24 publications

(32 citation statements)

References 11 publications

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“…It is proven to be highly effective regarding local control with low-grade toxicity, as shown in the patient’s clinical and imaging follow-up. This is supported also by the encouraging results obtained in other patients treated with this technique in our clinic [ 8 ]. Additional research is needed in order to generalize our results.…”

Section: Discussionsupporting

confidence: 83%

“…Wu, et al [ 7 ] described the physics basis of this technique, which improves the response of bulky tumors triggering the bystander effect in the normal cells adjacent to a tumor, where a very high dose of radiation is given to small areas inside the tumor. Amendola, et al presented the clinical results in a patient treated for a bulky cervical cancer with LRT showing complete local response [ 8 ]. In the present case presentation, we describe the use of LRT applied with modern radiotherapy techniques and combined with chemotherapy as a new approach to improve treatment results in bulky tumors.…”

Section: Discussionmentioning

confidence: 99%

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The Use of Lattice Radiation Therapy (LRT) in the Treatment of Bulky Tumors: A Case Report of a Large Metastatic Mixed Mullerian Ovarian Tumor

Suárez

Amendola

Pérez

et al. 2015

Cureus

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The objective of this teaching case is to report the excellent results of using lattice radiation therapy (LTR) for the treatment of a large metastasis from ovarian carcinosarcoma. This new technical concept extrapolates the traditional spatially fractionated radiation therapy (GRID) technique to advanced three-dimensional (3D) high-dose radiation therapy using modern instrumentation in radiation oncology. We report a case of a 61-year-old female with a large metastatic mass from ovarian carcinosarcoma treated by this procedure with excellent clinical and image-based follow-up results for more than four years.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

The Use of Lattice Radiation Therapy (LRT) in the Treatment of Bulky Tumors: A Case Report of a Large Metastatic Mixed Mullerian Ovarian Tumor

Suárez

Amendola

Pérez

et al. 2015

Cureus

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“…They allowed for delivery of doses in range of 20 Gy to the tumor volume, with acceptable toxicities, due to grid-like pattern of affected and non-affected tissue resulting in faster rate of regeneration [38]. Lattice RT was shown in several case reports to enable durable local control with tolerable side-effects in management of large abdominal metastatic masses of gynecological neoplasms [39,40]. GRID combined with ifosfamide showed potential e cacy in the treatment of extremity STS, suggesting that those techniques may prove useful in management of large RPS [41].…”

Section: Discussionmentioning

confidence: 99%

Definitive radiotherapy in the management of non-resectable or residual retroperitoneal sarcomas: institutional cohort analysis and systematic review

Sobiborowicz

Spałek

Czarnecka

et al. 2020

Preprint

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Background There is currently no consensus on optimal management of patients with primary or recurrent non-resectable/residual retroperitoneal sarcomas (RPS). The objective of this study was to document the outcomes of patients with primary or recurrent non-resectable/residual RPS treated in our center with definitive radiotherapy (RT), and to perform systematic review on that topic. Methods A retrospective analysis of consecutive RPS patients treated in our center between 2000 and 2019 was performed. All consecutive patients who underwent definitive conformal RT with image guidance for primary or recurrent non-resectable or macroscopically residual RPS were included. Additionally, the systematic review compliant with the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses was performed.Results 14 patients who met aforementioned criteria were found. Data on clinicopathological characteristics, RT and response to treatment were presented. RT allowed achieving prolonged local control of the disease i.e. no local progression of the disease for more than six months after RT in 12 patients. Achieved local control lasted more than 24 months in six cases, with none or minimal toxicity. 11 studies were included in the systematic review. Our results are in concordance to reports included in the review.Conclusions RT provided satisfactory local disease control with acceptable treatment tolerance in patients with primary or recurrent non-resectable/residual RPS. RT represents valuable treatment modality in this selected group of patients. Additional RT modalities i.e. particle therapy, MRI-guided RT or GRID/Lattice RT may be introduced to improve local control and minimize toxicity.

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“…For the last seven years, we have used LRT in 30 patients; most commonly in advanced gynecological cancer [7] , [8] . The case presented herein was the first patient with locally advanced lung cancer treated in our clinic with this technique.…”

Section: Discussionmentioning

confidence: 99%

Improved outcome of treating locally advanced lung cancer with the use of Lattice Radiotherapy (LRT): A case report

Amendola¹,

Pérez²,

Wu³

et al. 2018

Clinical and Translational Radiation Oncology

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LATTICE Radiotherapy with RapidArc for Treatment of Gynecological Tumors:Dosimetric and Early Clinical Evaluations

Cited by 24 publications

References 11 publications

The Use of Lattice Radiation Therapy (LRT) in the Treatment of Bulky Tumors: A Case Report of a Large Metastatic Mixed Mullerian Ovarian Tumor

The Use of Lattice Radiation Therapy (LRT) in the Treatment of Bulky Tumors: A Case Report of a Large Metastatic Mixed Mullerian Ovarian Tumor

Definitive radiotherapy in the management of non-resectable or residual retroperitoneal sarcomas: institutional cohort analysis and systematic review

Improved outcome of treating locally advanced lung cancer with the use of Lattice Radiotherapy (LRT): A case report

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