Latin American Collaborative Study of Congenital Malformations (ECLAMC): A Model for Health Collaborative Studies

Poletta, Fernando A.; Gili, Juan Antonio; Castilla, Eduardo E.

doi:10.1159/000356568

Cited by 22 publications

(17 citation statements)

References 18 publications

(24 reference statements)

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“…By using a descriptive cross-sectional study, 2,597 live and stillborn infants with isolated NTDs among 2,229,561 total births (TB) from 95 maternity hospitals of 3 South American countries participating in the Latin American Collaborative Study of Congenital Malformations (ECLAMC)[ 21 – 22 ] between 1990 and 2013, were analyzed: (Chile N = 521, TB = 565,238; Argentina N = 1619, TB = 1,310,367; Venezuela N = 457, TB = 353,956). Venezuela, where no fortification policy has been implemented, was used as control group.…”

Section: Methodsmentioning

confidence: 99%

Neural tube defects: Sex ratio changes after fortification with folic acid

Poletta

Rittler

Saleme³

et al. 2018

PLoS ONE

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BackgroundHistorically, neural tube defects (NTDs) have predominated in female infants but the reasons remain unclear. In South America, the pre- folic acid fortification (FAF) rates of NTDs were around 18/10,000 births for females and 12/10,000 births for males, with an estimated sex ratio (male/female) of 0.67. During the post- FAF period, unpublished routine reports have indicated changes in the sex ratio for these defects while some descriptive reports are controversial. To date and to our knowledge, however, no studies specifically focusing on these changes to test this hypothesis directly have been undertaken. The aim of this study was to analyze changes in the sex ratio of infants with NTDs after FAF in South American countries.Materials and methodsWith a descriptive cross-sectional study design, 2,597 infants with isolated NTDs born between 1990 and 2013 in 3 countries participating in the Latin American Collaborative Study of Congenital Malformations (ECLAMC) network were included: (Chile N = 521 and Argentina N = 1,619 [with FAF policies]; Venezuela N = 457 [without FAF policies; used as control]; total births = 2,229,561). The differences-in-differences method and Poisson regressions were used to evaluate the sex ratio shift from female to male before vs. after FAF, and to assess whether these differences were related to the fortification.Results and conclusionsIn Chile and Argentina the prevalence of NTDs, particularly anencephaly and cervico-thoracic spina bifida, showed a greater reduction rate in females than in males after FAF, resulting in a change of the sex ratio of infants with NTDs. Some mechanisms possibly involved in this differential reduction are proposed which might be useful to identify the pathogenesis of NTDs as a whole and specifically of those susceptible to the protective effect of folic acid.

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Section: Methodsmentioning

confidence: 99%

Neural tube defects: Sex ratio changes after fortification with folic acid

Poletta

Rittler

Saleme³

et al. 2018

PLoS ONE

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“…This observational descriptive study is based on clinical epidemiological data registered by the ECLAMC network (Castilla and Orioli, ; Poletta et al, ; http://www.eclamc.org/). A total of 25,082 malformed newborns were ascertained among 2,557,424 births (stillbirths weighing ≥ 500 g and livebirths) occurring between 1995 and 2012 in 129 maternity hospitals throughout nine South American countries.…”

Section: Methodsmentioning

confidence: 99%

“…The birth prevalence rate (BPR) of congenital anomalies (CAs) is heterogeneous and exhibits geographical and sociocultural variations throughout the world (López‐Camelo and Orioli, ; Gili et al, ; ICBDSR). The ECLAMC (Latin‐American Collaborative Study of Congenital Malformations) network (Castilla and Orioli, ; Poletta et al, ) has studied CAs in South America for over 40 years. Previously, the ECLAMC has observed heterogeneous rates of CA across countries (López Camelo and Orioli, ).…”

Section: Introductionmentioning

confidence: 99%

Descriptive analysis of high birth prevalence rate geographical clusters of congenital anomalies in South America

Gili

Poletta

Giménez

et al. 2016

Birth Defects Research

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“…Cabe aclarar que todos los casos tuvieron estudios citogenéticos normales y no se detectaron antecedentes familiares de relevancia en ninguno de los casos. La valoración de los casos ECLAMC siguió la metodología ECLAMC descrita para el estudio [10], además de consultas convencionales del servicio de genética. El caso valorado en el HUSI fue atendido por el servicio de genética.…”

Section: Serie De Casosunclassified

Exposición prenatal a misoprostol y malformaciones congénitas asociadas. Serie de casos

et al. 2016

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El misoprostol es una sustancia análoga de la prostaglandina E1 con propiedades abortivas de eficacia limitada, que se ha asociado con la presencia de alteraciones congénitas en recién nacidos expuestos in utero. Este artículo presenta cinco casos de recién nacidos con defectos congénitos captados a través del proyecto ECLAMC-Colombia y un caso valorado por interconsulta al servicio de Genética en el Hospital Universitario San Ignacio con antecedente de exposición in utero a misoprostol. En esta serie, las alteraciones más frecuentemente descritas asociadas a la exposición a misoprostol fueron pies equinovaros, afección de pares craneales y defectos por reducción de miembros. Aunque persiste la polémica sobre los efectos teratogénicos de este medicamento, es necesario reportar los casos en los que se encuentre al menos una asociación temporal entre exposición y malformaciones congénitas, con el objetivo de recabar evidencia sobre sus potenciales efectos teratogénicos.

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Latin American Collaborative Study of Congenital Malformations (ECLAMC): A Model for Health Collaborative Studies

Cited by 22 publications

References 18 publications

Neural tube defects: Sex ratio changes after fortification with folic acid

Neural tube defects: Sex ratio changes after fortification with folic acid

Descriptive analysis of high birth prevalence rate geographical clusters of congenital anomalies in South America

Exposición prenatal a misoprostol y malformaciones congénitas asociadas. Serie de casos

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