Latex use as an occlusive membrane for guided bone regeneration

Abstract

Latex extracted from Hevea brasiliensis was used as an occlusive membrane for guided bone regeneration. Twenty-four rabbits were divided in two groups: treated and control group. Critical size bone defects (2 cm × 1 cm) were surgically made in the rabbit calvarium. Two latex membranes were implanted in each animal of the treated group, whereas the control defect was filled only with autogenous blood clot. After 15, 30, 60, and 120 days, animals from each group were euthanized, and the samples with regenerated bone were removed. No signs of allergy or rejection were noticed around the calvarial bone defect of the treated group. In the histological analysis, no foreign body inflammatory reaction was observed in the adjacent tissues in contact with the membranes demonstrating that latex can be used at injured sites as an aid in the healing process. Histological analysis, digital radiography, and electron spin resonance were used to evaluate the progress of bone repair. The results show significant differences between groups (p < 0.05) suggesting that latex membranes accelerates healing in critical bone defects.

Natural rubber latex used as drug delivery system in guided bone regeneration (GBR)

“…In a previous study, we have tested NRLb as an occlusive membrane for Guided Bone Regeneration (GBR) with promising results 13 . We tested our membrane in a critical defect in the rabbit calvaria, and did show that the wound was healed only with NRLb.…”

Qualitative histologic evaluation of the tissue reaction to the Polyurethane resin (Ricinus communis based biopolymer) implantation assessed by light and scanning electron microscopy

“…Biocompatibility involves a perfect integration between bone and implant, that implies in lack of inflammatory reaction at the bone/implant interface [5,12,15,16,28] . Some of these features were observed in this work such as: a perfect union between the polymer and surgical bone bed surface, lack of inflammatory reaction, lack of bone resorption and presence of a thin layer of osteogenic material covering the polymer surface in contact with the surgical bone bed, that is, at the bone/implant interface.…”

“…Numerous synthetic bone promoting biomaterials such as: tricalcium phosphate [12,13] , porous hydroxyapatite [14] , biopolymer [15][16][17] and bioactive glass [18,19] have been developed. In this context, injectable scaffolds represent a very interesting option because they are easily adapted in the shape of defect, allowing the tissue repair after minimally invasive administration.…”

Evaluation on Cytotoxicity of Natural Rubber Latex Nanoparticles and Application in Bone Tissue Engineering

“…Currently, more than 90% of NRL comes from one single tropical tree species Hevea brasiliensis (para rubber tree). Recently, promising results in the use of NRL from Hevea brasiliensis rubber tree to produce replacement and regeneration tissues has been reported [1][2][3] . Among them, wound healing in cutaneous tissues, eardrum replacement, bone regeneration, and dental alveolus replacement afford a unique means to repair or replace the failing organs or tissues 2) .…”