Latex proteins from <i>Plumeria pudica</i> reduce ligature‐induced periodontitis in rats

Oliveira, Lucas Eduardo Silva; Moita, Lucas Arruda; Souza, Bruna S; Oliveira, Naylla M; Sales, Ana Clara Silva; Barbosa, Mayck Silva; Silva, Francisca D S; Farias, Alan L C; Lopes, Víctor Lucas Ribeiro; França, Luiz Felipe C.; Alves, Even Herlany Pereira; Freitas, Cléverson D.T.; Ramos, Márcio V.; Vasconcelos, Daniel Fernando Pereira; Oliveira, Jefferson Soares de

doi:10.1111/odi.13803

Cited by 2 publications

(1 citation statement)

References 44 publications

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“…attracts munias for nesting [25]. Even though the branching points of the plant stem provided a proper substratum for the nest, they failed to provide further protection from predators due to sparse, dense coverage.…”

Section: Resultsmentioning

confidence: 99%

Nest Site Preference of Lonchura striata acuticauda, in Semi Urban Areas of Kollam District, Kerala, India: A Case Study

Cheriyan,

Devan,

Joseph

2024

UPJOZ

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Disturbances caused by man-made structures significantly influence the nest site selection of birds. However, the remarkable adaptability of Lonchura striata acuticauda to such disturbances is a fascinating aspect of its behaviour. This adaptability leads to the unique nest distribution of a bird’s community, often favouring human-associated bird species. The present investigation into the nesting preference of Lonchura striata acuticauda for garden plants was conducted in a semi-urban village, Tazhava of Kollam district in Kerala, between August 2021 and September 2022. Nesting affinity of white-rumped munia to different garden plants, the number of nesting attempts and renovation on different plant species, and nesting parameters, such as the number of completed and incompleted nests, clutch size, egg predated, and chick fledged on each plant species were recorded during their breeding period. A total of 45 nests of Lonchura striata acuticauda were observed on different garden plant species in 25 homes with well-maintained gardens; thirty-seven were completed, while eight nests were abandoned in the helmet stage. Lonchura striata acuticauda showed varying nest site preferences; with the highest nest site preference of 36 % on Callisia repens, followed by Epipremnum aureum (27%), Cleodendrum thomsoniae (18%), Bambusa multiplex (7%) and an equal preference of 4% for Plumeria pudica, Ixora taiwanensis and Melia azadirachta. Most of the nests recorded an average clutch size of 3-5 eggs. Eighty-eight percent of the nests constructed on Callisia repens were completed, with 87% of eggs hatched and chick-fledged, with a predation rate of 13%. Nesting munias are protected from the dense foliage and vines of the garden plants where the birds build a nest which also minimises the energy wastage in finding materials for nest building. Repeated nesting attempts and nest renovation on the same plant were observed mainly in hanging ornamental plants.

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Section: Resultsmentioning

confidence: 99%

Nest Site Preference of Lonchura striata acuticauda, in Semi Urban Areas of Kollam District, Kerala, India: A Case Study

Cheriyan,

Devan,

Joseph

2024

UPJOZ

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Protective Effect of Plumeria Pudica Latex Proteins on Intestinal Mucositis Induced by 5-Fluorouracil

Andrade

Souza

Araújo³

et al. 2023

MRMC

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Intestinal mucositis is characterized by inflammation and ulceration of the mucosa that affects the gastrointestinal tract and it is associated with the administration of some drugs, such as 5-fluorouracil (5-FU), a conventional chemotherapy used in clinics for cancer therapy. Inside intestinal mucosa the 5-FU acts leading to oxidative stress, stimulating the production/release of proinflammatory cytokines, local accumulation of neutrophils and consequent tissue damage. These alterations favor bacterial proliferation, triggering secondary infections and they are also responsible for undesired effects such as myelosuppression and diarrhea. These factors negatively impact the quality of life of oncological patients and explains why they commonly interrupt their treatment prematurely. Currently, there is no specific drug with the ability to completely avoid this condition, so the search for new molecules with pharmacological properties that can be used for preventing or ameliorating intestinal mucositis is important. Plumeria pudica is a plant that produces latex containing molecules with therapeutic potential. A protein fraction obtained from this latex (LPPp), which comprises a well-defined mixture of chitinases, proteinases proteinase inhibitors, was demonstrated to have antioxidant and anti-inflammatory activities, preserving tissue glutathione and malondialdehyde concentration, reducing superoxide dismutase and myeloperoxidase activity, and reducing the level of proinflammatory cytokines in different experimental models. Given this scenario, inflammation and oxidative stress are directly involved in the pathogenesis of intestinal mucositis promoted by 5-FU. So, the hypothesis in question is that LPPp could inhibit these factors to attenuate the cytotoxicity of this pathology associated to 5-FU-treatment. This article brings new insights into the potential of the laticifer proteins extracted from the latex of P. pudica and opens new perspectives for the treatment of this type of intestinal mucositis with LPPp.

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Latex proteins from Plumeria pudica reduce ligature‐induced periodontitis in rats

Cited by 2 publications

References 44 publications

Nest Site Preference of Lonchura striata acuticauda, in Semi Urban Areas of Kollam District, Kerala, India: A Case Study

Nest Site Preference of Lonchura striata acuticauda, in Semi Urban Areas of Kollam District, Kerala, India: A Case Study

Protective Effect of Plumeria Pudica Latex Proteins on Intestinal Mucositis Induced by 5-Fluorouracil

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